Pathology Faculty Member

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    Jeannette Guarner, MD

    Infectious Disease Pathology

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Pathology Division(s):
    Clinical Pathology


    Email Address:
    jguarne@emory.edu


    Education:

    BS   Colegio Oxford, Mexico City, 1973 - 1977

    MD   Medical School, La Salle School of Medicine, M¿xico City, 1977 - 1983



    Research Interests:

    - Helicobacter pylori infections in children and adults.
    When I was working at the National Cancer Institute in Mexico, I started studying the acute and chronic effects of Helicobacter pylori infection in adults. Together with Stanford University and a group in Chiapas State in Mexico, we did a case control trial to see if eradiaction of H. pylori decreased the amount of preneoplastic lesions. My interest has expanded to the study of this infection in children and I am currently involved in several projects in this population.


    - Emerging and Re-emerging infections
    Upon arriving at the Centers for Disease Control and Prevention (CDC), I was integrally involved in high-prorfile outbreak investigations of emerging and re-emerging infectious diseases. The CDC pathology team has developed a variety of immunohistochemical and molecular assays to detect these patholgens. Detection of microbial antigens by immunohsitochemical methos in tissues has to be correlated with other laboratory tests. The combination of tissue and laboratory diagnosis of infectious agents is of vital importance to detect these emerging and re-emerging infections so that public health authorities place control and prevention measures.



    Honors / Awards:

    Milipub club, 2011

    Specialty Boards:

    1987  American Board of Pathology (anatomic and clinical pathology)


    1988  Mexican Board of Anatomic Pathology


    Selected Publications:

    Published and Accepted Research Articles -

    Hassan HA, Majid RA, Rashid NG, Nuradeen BE, Abdulkarim QH, Hawramy TA, Rashid RM, Farris AB, Guarner J, Hughson MD. Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan. BMC Infectious Diseases 2013, 13:91 [Epub Feb 2013]


    Guarner J. Detection of microorganisms in ganulomas that have been formalin-fixed: Review of the literature regarding use of molecular methods. Scientifica. Vol 2012, Article ID 494571, http://dx.doi.org/10.6064/2012/494571


    Roberts DJ, Wilson ML, Nelson AM, Adesina AM, Fleming KA, Milner D, Guarner J, Rebbeck TR, Castle P, Lucas S. The good news about cancer in developing countries--pathology answers the call. Lancet. 2012;379(9817):712.


    Tarkhashvili N, Chakvetadze N, Mebonia N, Chubinidze M, Bakanidze L, Shengelidze V, Mirtskhulava M, Chachava T, Katsitadze G, Gabunia U, Kordzaia D, Imnadze P, Guarner J, Sobel J. Traditional risk factors for Helicobacter pylori infection not found among patients undergoing diagnostic upper endoscopy-Republic of Georgia, 2007-2008. Int J Infect Dis. 2012;16:e697-702. [Epub 2012 Aug 4]


    RJ Molinaro, AM Winkler, CS Kraft, CR Fantz, SR Stowell, JC Ritchie, DD Koch, S Heron, J Liebzeit, S Santen, J Guarner. Teaching laboratory medicine to medical students: Implementation and assessment of a Medical Student Clinical Laboratory Experience (MSCLE). Arch Pathol Lab Med 2012;136:1423-1429


    S Patel, JB Smith, E Kurbatova, J Guarner. Factors that impact turnaround time of surgical pathology specimens in an academic institution. Hum Pathol 2012;43:1501-5 (Epub 3/8/2012).


    Zane S, Guarner J. Gynecologic Clostridial Toxic Shock in Women of Reproductive Age. Curr Infect Dis Rep. 2011;13:561-70 Epub 9/2/2011.


    Guarner J, Brandt ME. Histopathologic diagnosis of fungal infections in the 21st century. Clin Micro Rev 2011; 24:247-80


    Schuetz A, Guarner J, Packard MM, Zaki SR, Bahig SM, Opreas-Ilies G. Infectious Disease Immunohistochemistry in Placentas from HIV-Positive and HIV-Negative Patients. Pediatr Dev Pathol. 2011;14:180-8.


    J Guarner, CS Kraft. Need for clinicopathologic correlation of Clostridium difficile colitis in view of molecular diagnosis. Clin Infect Dis 2011;54:156.


    Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, Chong S, Colletti RB, Casswall T, Elitsur Y, Guarner J, Kalach N, Madrazo A, Megraud F, Oderda G; on behalf of the H. pylori working groups of ESPGHAN, NASPGHAN. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53:230-43.


    Guarner J, Kalach N, Elitsur Y, Koletzko S. Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009. Eur J Pediatr. 2010 Jan;169(1):15-25. Epub Jul 18,2009.


    J Gutman, J Guarner. Pediatric malaria: 8 year case series in Atlanta, Georgia, and review of the literature. J Travel Med 2010;17:334-8.


    WJ Shieh, CD Paddock, E Lederman, CY Rao, LH Gould, M Mohamed, F Mosha, J Mghamba, P Bloland, MK Njenga, D Mutonga, AA Samuel, J Guarner, RF Breiman, SR Zaki. Pathologic studies on suspect animal and human cases of Rift Valley fever from an outbreak in Eastern Africa, 2006-2007. Am J Trop Med Hyg. 2010;83:38-42.


    J Guarner, J Hochman, E Kurbatova, R Mullins. Study of outcomes associated with hyponatremia and hypernatremia in children. Pediatr Dev Pathol 2010;14(2):117-23.


    Guarner J, Bhatnagar J, Shane AL, Jones T, DeLeon-Carnes MN, Schemankewitz E, Zaki SR. Correlation of the detection of Clostridium difficile toxins in stools and presence of the clostridia in tissues of children. Hum Pathol 2010;41:1586-92 (epub Jul 23).


    Guarner J, Atuan MA, Nix B, Mishak C, Vejjajiva C, Curtis C, Park S, Mullins R. Process to evaluate hematological parameters that reflex to manual differential cell counts in a pediatric institution. Clin Lab 2010;56:21-7.


    Ho CS, Bhatnagar J, Cohen AL, Hacker JK, Zane SB, Reagan S, Fischer M, Shieh WJ, Guarner J, Ahmad S, Zaki SR, McDonald LC. Undiagnosed cases of fatal Clostridium-associated toxic shock in Californian women of childbearing age. Am J Obstet Gynecol. 2009;201:459.e1-7. Epub 2009 Jul 22.


    Talarico S, Gold BD, Fero J, Thompson DT, Guarner J, Czinn S, Salama NR. Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles. J Clin Microbiol 2009; 47:1680-8. Epub Apr 22, 2009.


    Tarkhashvili N, Beriashvili R, Chakvetadze N, Moistsrapishvili M, Chokheli M, Sikharulidze M, Malania L, Abazashvili N, Jhorjholiani E, Chubinidze M, Ninashvili N, Zardiashvili T, Gabunia U, Kordzaia D, Imnadze P, Sobel J, Guarner J. Helicobacter pylori infection in patients undergoing upper endoscopy, Republic of Georgia. Emerg Infect Dis. 2009;15:504-5.


    Roberts A, Lamirande EW, Vogel L, Jackson JP, Paddock CD, Guarner J, Zaki SR, Sheahan T, Baric R, Subbarao K. Animal models and vaccines for SARS-CoV infection. Virus Res. 2008;133:20-32.


    Stamm B, Moschopulos M, Guarner J, Genrich GL, Zaki SR. Immunohistochemical demonstration of neuroinvasion by Mycoplasma pneumoniae in fatal acute disseminated encephalomyelitis. Emerg Infect Dis 2008;14:641-3.


    Benson R, Tondella ML, Bhatnagar J, Carvalho MGS, Sampson JS, Talkington DF, Whitney A, Mothershed E, McGee L, Carlone G, Moore M, McClee V, Guarner J, Zaki S, Cronin K, Baughman AL, Han J, Fields BS. Development and evaluation of a novel multiplex PCR technology for molecular differential detection of bacterial respiratory disease pathogens. J Clin Microbiol 2008;46:2074-7.


    Rouphael NG, O'Donnell JA, Bhatnagar J, Lewis F, Polgreen PM, Beekmann S, Guarner J, Killgore GE, Coffman B, Campbell J, Zaki SR, McDonald LC. Clostridium difficile-associated diarrhea: an emerging threat to pregnant women. Am J Obstet Gynecol 2008;198:635.e1-6


    Paddock CD, Sanden GN, Cherry JD, Gal AA, Langston C, Tatti KM, Wu KH, Goldsmith CS, Greer PW, Montague JL, Eliason MT, Holman RC, Guarner J, Shieh WJ, Zaki SR. Pathology and pathogenesis of gatal Bordetella pertussis infection in infants. Clin Infect Dis. 2008;47:328-38


    Froberg MK, Dannen D, Bernier N, Shieh WJ, Guarner J, Zaki S. Case report: spontaneous splenic rupture during acute parasitemia of Babesia microti. Ann Clin Lab Sci 2008;38:390-2.


    Guarner J, Paddock CD, Bartlett J, Zaki SR: Adrenal gland hemorrhage in patients with fatal bacterial infections. Mod Pathol 2008;21:1113-20.


    Kallen AJ, Jhung MA, Cheng S, Hess T, Turabelidze G, Abramova L, Arduino M, Guarner J, Pollack B, Saab G, Patel PR. Gadolinium-containing magnetic resonance imaging contrast and nephrogenic systemic fibrosis: a case-control study. Am J Kidney Dis 2008;51:966-75


    Lee EH, Ferguson D, Jernigan D, Greenwald M, Cote T, Bos JE, Guarner J, Zaki S, Schuchat A, Beall B. Srinivasan A. Invasive group-A streptococcal infection in an allograft recipient. A case report. J Bone Joint Surg Am. 2007;89:2044-7.


    Walsh JJ, Pesik N, Quinn CP, Urdaneta V, Dykewicz CA, Boyer AE, Guarner J, Wilkins P, Norville KJ, Barr JR, Zaki SR, Patel JB, Reagan SP, Pirkle JL, Treadwell TA, Messonnier NR, Rotz LD, Meyer RF, Stephens DS. A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor. Clin Infect Dis 2007;44:968-71


    Birkness KA, Guarner J, Sable SB, Tripp RA, Kellar KL, Bartlett J, Quinn FD. An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection. Immunol Cell Biol 2007;85:160-8.


    Kam YW, Kien F, Roberts A, Cheung YC, Lamirande EW, Vogel L, Chu SL, Tse J, Guarner J, Zaki S, Subbarao K, Peiris M, Nal B, Altmeyer R. Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro. Vaccine. 2007;25:729-40.


    Bhatnagar J, Guarner J, Paddock CD, Shieh WJ, Lanciotti RS, Marfin AA, Campbell GL, Zaki SR. Detection of West Nile virus in formalin-fixed, paraffin-embedded human tissues by RT-PCR: A useful adjunct to conventional tissue-based diagnostic methods. J Clin Virol 2007;38:106-11.


    Genrich GL, Guarner J, Paddock CD, Shieh WJ, Greer PW, Barnwell JW, Zaki SR. Fatal malaria infection in travelers: Novel immunohistochemical assays for the detection of Plasmodium falciparum in tissues and implications for pathogenesis. Am J Trop Med Hyg 2007;76:251-259


    Guarner J, Bhatnagar J, Shieh WJ, Nolte KB, Klein D, Gookin MS, Penaranda S, Oberste MS, Jones T, Smith C, Pallansch MA, Zaki SR. Detection of infectious agents in fatal sporadic myocarditis using histopathology, immunohistochemistry, and PCR. Hum Pathol. 2007; 27:1412-19.


    Richards FO Jr, Amann J, Arana B, Punkosdy G, Klein R, Blanco C, Lopez B, Mendoza C, Dom¿nguez A, Guarner J, Maguire JH, Eberhard M. No depletion of Wolbachia from Onchocerca volvulus after a short course of rifampin and/or azithromycin. Am J Trop Med Hyg. 2007;77:878-882.


    Guarner J, Bartlett J, Shieh WJ, Paddock CD, Visvesvara GS, Zaki SR. Histopathologic spectrum and immunohistochemical diagnosis of amebic meningoencephalitis. Mod Pathol 2007: 20:1230-7.


    Pogue M, Burton S, Kreyling P, Naponick J, Stefanski J, Ratard R, Bulens S, Cope J, Tuttle J, Ladson J, Tobin-D'Angelo M, Arnold K, Hageman J, Gorwitz R, Fosheim G, McAllister S, Anderson K, Patel J, Limbago B, Fry A, Brammer L, Dhara R,Shay D, Guarner J, Zaki S, Brunkard J, Kallen A. Severe Methicillin-Resistant Staphylococcus aureus Community-Acquired Pneumonia Associated with Influenza --- Louisiana and Georgia, December 2006--January 200. MMWR Morb Mortal Wkly Rep 2007;56:325-329.


    Cummins JE, Jr, Guarner J, Flowers L, Guenthner PC, Bartlett J, Morken T, Grohskopf LA, Paxton L, Dezzutti CS. Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrob Agents Chemother 2007;51:1770-9.


    Guarner J, Packard MM, Nolte KB, Paddock CD, Shieh WJ, Tondella ML, McGee L, Zaki SR. Usefulness of immunohistochemical diagnosis of Streptococcus pneumoniae in formalin-fixed, paraffin-embedded specimens compared with culture and gram stain techniques. Am J Clin Pathol 2007;127:612-8.


    Cohen AL, Bhatnagar J, Reagan S, Zane SB, D'Angeli MA, Fischer M, Killgore G, Kwan-Gett TS, Blossom DB, Shieh WJ, Guarner J, Jernigan J, Duchin JS, Zaki SR, McDonald LC. Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstet Gynecol. 2007;110:1027-1033.


    Penn RG, Guarner J, Sejvar JJ, Hartman H, McComb RD, Nevins DL, Bhatnagar J, Zaki SR. Persistent neuroinvasive West Nile virus infection in an immunocompromised patient. Clin Infect Dis 2006;42:680-683


    Tsai CJ, Herrera-Goepfert R, Tibshirani RJ, Yang S, Mohar A, Guarner J, Parsonnet J. Changes of gene expression in gastric preneoplasia following Helicobacter pylori eradication therapy. Cancer Epidemiol, Biomark Prev 2006;15:272-80.


    Tatti KM, Wu KH, Sanden GN, Greer PW, Sumner J, Guarner J, Paddock CD, Zaki SR. Molecular diagnosis of Bordetella pertussis infection by evaluation of formalin-fixed tissue specimens. J Clin Microbiol 2006;44:1074-76.


    Guarner J, Zaki S. Histopathology and immunohistochemistry in the diagnosis of bioterrorism agents. Review. J Histochem Cytochem 2006;54:3-11.


    Guarner J, Bartlett J, Reagan S, Fischer M, Finn S, O'Briain DS, Black M, Hood J, Zaki SR. Immunohistochemical evidence of Clostridium sp., Staphylococcus aureus, and group A streptococcus in severe soft tissue infections related to injection drug use. Hum Pathol 2006; 37:1482-88.


    Guarner J, Paddock CD, Shieh WJ, Packard MP, Patel M, Montague JL, Uyeki TM, Bhat N, Balish A, Lindstrom S, Klimov A, Zaki SR. Histopathologic and immunohistochemical features of influenza virus infections in children during the 2003-04 season. Clin Infect Dis 2006;43:132-140.


    Guarner J, Sumner J, Paddock CD, Shieh WJ, Greer PW, Reagan S, Fischer M, Van Beneden CA, SR Zaki. Diagnosis of invasive group A streptococcal infections by using immunohistochemical and molecular assays. Am J Clin Pathol 2006;126:148-155.


    Karls RK, Guarner J, McMurray DN, Birkness KA, Quinn FD. Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis. Microbiology 2006;152:1591-600.


    Fischer SA, Graham MB, Kuehnert MJ, Kotton CN, Srinivasan A, Marty FM, Comer JA, Guarner J, Paddock CD, DeMeo DL, Shieh WJ, Erickson BR, Bandy U, DeMaria A, Davis JP, Delmonico FL, Pavlin B, Likos A, Vincent MJ, Sealy TK, Goldsmith CS, Jernigan DB, Rollin PE, Packard MM, Patel M, Kehl SC, Johnson CP, Schulzetenberg C, Rowland C, Helfand RF, Nichol ST, Fishman JA, Ksiazek T, Zaki SR. Transmission of lymphocytic choriomeningitis virus through organ transplantation. N Eng J Med 2006;354:2235-49.


    Shieh WJ, Hsiao CH, Paddock C, Guarner J, Muller L, Goldsmith C, Tatti K, Packard M, Su IJ, Zaki SR. Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in a fatal case of severe acute respiratory syndrome in Taiwan. Hum Pathol 2005;36:303-309.


    Bhat N, Wright J, Broder K, Murray E, Greenberg M, Glover M, Likos A, Posey D, Klimov A, Lindstrom S, Balish A, Guarner J, Paddock C, Shieh WJ, Zaki SR, Sejvar J, Shay D, Harper S, Cox N, Fukuda K, Uyeki T. Deaths in children associated with influenza, United States, 2003-04. N Eng J Med 2005;353:2559-2567.


    Fischer M, Bhatnagar J, Guarner J, Reagan S, Hacker JK, Van Meter SH, Poukens V, Whiteman DB, Iton A, Cheung M, Dassey DE, Shieh WJ, Zaki SR. Four deaths associated with Clostridium sordellii endometritis following medical abortions. N Eng J Med 2005; 353:2352-2360.


    Ganley-Leal LM, Guarner J, Todd CW, Da'Dara AA, Freeman GL, Boyer AE, Harn DA, Secor WE. Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines. Parasite Immunol. 2005;27:341-9.


    Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE, Fink A, Gilmore JT, Staley C, Ward A, Ali O, Binderow S, Cohen S, Grohskopf LA, Paxton L, Hart CE, Dezzutti CS. A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J Infect Dis 2005; 192:1545-56.


    Guarner J, Bartlett J, Seitz R, Whistler T, Herrera-Goepfert R, Mohar A, Sanchez L, Halperin D, Parsonnet J. Cell proliferation and inflammation on biopsy samples with multifocal atrophic gastritis before and 1 year after Helicobacter pylori eradication. Arch Pathol Lab Med 2005;129:1451-1456.


    Srinivasan A, Burton EC, Kuehnert M, Rupprecht C, Sutker WL, Ksiazek TG, Paddock C, Guarner J, Shieh WJ, Goldsmith C, Hanlon K, Zoretic J, Fischbach B, Niezgoda M, El-Feky WH, Orciari L, Sanchez EQ, Likos A, Klintmalm GB, Cardo D, LeDuc J, Chamberland M, Jernigan D, Zaki S. Transmission of rabies virus from an organ donor to four transplant recipients. N Engl J Med 2005;352:1103-1111.


    Roberts A, Vogel L, Guarner J, Hayes N, Murphy B, Zaki SR, Subbarao K. Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters. J Virol 2005; 79:503-11.


    Maines TR, Lu XH, Erb SM, Edwards L, Guarner J, Greer PW, Nguyen DC, Szretter K, Thawatsupha P, Chittaganpitch M, Waicharoen S, Nguyen DTN Nguyen, Nguyen HHT, Kim JH, Hoang LT, Kang C, Phuong LS, Lim W, Zaki SR, Donis RO, Cox NJ, Katz JM, Tumpey TM. Avian influenza (H5N1) viruses isolated from humans in Asia during 2004 exhibit increased virulence in mammals. J Virol 2005;79:11788-11800.


    Guarner J, Shieh WJ, Chu M, Perlman DC, Kool J, Gage KL, Ettestad P, Zaki SR. Persistent Yersinia pestis antigens in ischemic tissues of a patient with septicemic plague. Hum Pathol 2005;36:850-853.


    Ley C, Mohar A, Guarner J, Herrera-Goepfert R, Sanchez Figueroa L, Halperin D, Johnstone I, Parsonnet J. Helicobacter pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial. Cancer Epidemiol Biomark Prev 2004;13:4-10.


    Guarner J, Shieh WJ, Hunter S, Paddock CD, Morken T, Campbell GL, Marfin AA, Zaki SR. Clinicopathologic study and laboratory diagnosis of 23 cases with West Nile Virus encephalomyelitis. Hum Pathol 2004;35:983-990.


    Guarner J, Greer PW, Whitney A, Shieh WJ, Fischer M, White EH, Carlone GM, Stephens DS, Popovic T, Zaki SR. Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays. Am J Clin Pathol 2004; 122:754-764.


    Sejvar JJ, Chowdary Y, Schomogyi M, Stevens J, Patel J, Karem K, Fischer M, Kuehnert MJ, Zaki SR, Paddock CD, Guarner J, Shieh WJ, Patton JL, Bernard N, Li Y, Olson VA, Kline RL, Loparev VN, Schmid DS, Beard B, Regnery RR, Damon IK. Human monkeypox infection: a family cluster in the Midwestern United States. J Infect Dis 2004; 190:1833-1840.


    Okenu DMN, Ofielu LO, Easley KA, Guarner J, Spotts-Whitney EA, Raghunathan PL, Stienstra Y, Asamoa K, van der Werf TS, van der Graaf WTA, Tappero JW, Ashford DA, King CH. Immunoglobulin M antibody responses to Mycobacterium ulcernas allow discrimination between cases of active Buruli ulcer disease and matched family controls in areas where the disease is endemic. Clin Diag Lab Immunol 2004;11:387-391.


    Cushing MM, Brat DJ, Mosunjac MI, Hennigar RA, Jernigan D. Lanciotti R, Petersen LR, Goldsmith C, Rollin PE, Shieh WJ, Guarner J, Zaki SR. Fatal West Nile virus encephalitis in a renal transplant recipient. Am J Clin Pathol 2004;121:26-31.


    Guarner J, Johnson BJ, Paddock CD, Shieh WJ, Goldsmith CS, Reynolds MG, Damon IK, Regnery RL, Zaki SR, and the Veterinary Monkeypox Virus Working Group. Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis 2004; 10: 426-431.


    Guarner J, de Leon-Bojorges B, Lopez-Corella E, Ferebee-Harris T, Gooding L, Garnett CT, Shieh WJ, Dawson J, Erdman D, Zaki SR. Intestinal intussusception associated with adenovirus infection in Mexican children. Am J Clin Pathol 2003; 120:845-850.


    Torres-Velez F, Nace EK, Won KY, Bartlett J, Eberhard M, Guarner J. Development of an immunohistochemistry assay for detection of babesiosis in formalin-fixed, paraffin-embedded tissues. Am J Clin Pathol 2003; 120:833-838.


    Weinberg M, Weeks J, Lance-Parker S, Traeger M, Wiersma S, Phan Q, Dennison D, MacDonald P, Lindsley M, Guarner J, Connolly P, Hajjeh R. Severe histoplasmosis in travelers to Nicaragua. Emerg Infect Dis 2003; 9:1322-1325.


    Shieh WJ, Guarner J, Paddock C, Greer, P, Tatti K, Fischer M, Layton M, Philips M, Bresnitz E, Quinn CP, Popovic T, Perkins BA, Zaki SR and anthrax bioterrorism investigation team. The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax. Am J Pathol, 2003;163(5):1901-10.


    Guarner J, Jernigan JA, Shieh WJ, Tatti K, Flannagan LM, Stephens DS, Popovic T, Ashford DA, Perkins BA, Zaki SR, the Inhalational Anthrax Pathology Working Group. Pathology and pathogenesis of bioterrorism-related inhalational anthrax . Am J Pathol 2003;163:701-709.


    Guarner J, Bartlett J, Spotts Whitney EA, Raghunathan PL, Stienstra Y, Asamoa K, Etuaful S, Klutse E, Quarshie E, van der Werf TS, van der Graaf WTA, King CH, Ashford DA. Histo- pathologic features of Mycobacterium ulcerans infection. Emerg Infect Dis 2003; 9:651-656.


    Guarner J, Bartlett J, Whistler T, Pierce-Smith D, Owens M, Kreh R, Czinn S, Gold BD. Can pre-neoplastic lesions be detected in gastric biopsies of children with Helicobacter pylori infection? J Pediatr Gastroenterol Nutr 2003; 37:309-314.


    Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ, and the SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-1966.


    Guarner J, Herrera-Goepfert R, Mohar A, Smith C, Schofield A, Halperin D, Sanchez L, Parsonnet J. Diagnostic yield of gastric biopsy specimens when screening for preneoplastic lesions. Hum Pathol 2003; 34: 28-31.


    Jernigan DB, Raghunathan PL, Bell BP, Brechner R, Bresnitz EA, Butler JC, Cetron M, Cohen M, Doyle T, Fischer M, Green C, Griffith KS, Guarner J, Hadler JL, Hayslett JA, Meyer R, Petersen LR, Phillips M, Pinner R, Popovic T, Quinn CP, Reefhuis J, Reissman D, Rosenstein N, Schuchat A, Shieh WJ, Siegal L, Swerdlow DL, Tenover FC, Traeger M, Ward JW, Weisfuse I, Wiersma S, Yeskey K, Zaki S, Ashford DA, Perkins BA, Ostroff S, Hughes J, Fleming D, Koplan JP, Gerberding JL, and the National Anthrax Epidemiologic Investigation Team. Investigation of bioterrorism-related anthrax, United States, epidemiologic findings. Emerg Infect Dis 2002;8: 1019-28.


    Wong KT, Shieh WJ, Kumar S, Norain K, Abdullah W, Guarner J, Goldsmith CS, Chua KB, Lam SK, Tan CT, Goh KJ, Chong HT, Jusoh R, Rollin PE, Ksiazek TG, Zaki SR. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002;161:2153-67.


    Mohar A, Ley C, Guarner J, Herrera-Goepfert R, Sanchez Figueroa L, Halperin D, Eradication rate of Helicobacter pylori in a Mexican population at high risk for gastric cancer and use of serology to assess cure. Am J Gastroenterol 2002;97: 2530-2535.


    Guarner J, Shieh WJ, Greer PW, Gabastou JM, Chu M, Hayes E, Nolte KB, Zaki SR. Immunohistochemical detection of Yersinia pestis in formalin-fixed, paraffin-embedded tissue. Am J Clin Pathol 2002;117: 205-209.


    Guarner J, Herrera-Goepfert R, Mohar A, Sanchez L, Halperin D, Ley C, Parsonnet J. Gastric atrophy and extent of intestinal metaplasia in a cohort of Helicobacter pylori infected patients. Hum Pathol 2001;32:31-35.


    Jernigan JA, Stephens DS, Ashford DA, Omenaca C, Topiel MS, Galbraith M, Tapper M, Fisk TL, Zaki SR, Popovic T, Meyer RF, Quinn CP, Harper SA, Fridkin SK, Sejvar JJ, Shepard CW, McConnell M, Guarner J, Shieh WJ, Malecki JM, Gerberding JL, Hughes JM, Perkins BA, and members of the anthrax bioterrorism investigation team. Bioterrorism-related inhalational anthrax: the firs 10 cases reported in the United States. Emerg Infect Dis 2001;7: 933-944.


    Ley C, Mohar A, Guarner J, Herrera-Goepfert R, Sanchez-Figueroa L, Halperin D, Parsonnet J. Screening markers for chronic atrophic gastritis in Chiapas, Mexico. Cancer Epidemiol Biomark Prev 2001;10:107-112.


    Guarner J, Shieh WJ, Morgan J, Bragg SL, Bajani MD, Tappero JW, Zaki SR. Leptospirosis mimicking acute cholecystitis among athletes participating in a triathlon. Hum Pathol 2001;32: 750-752.


    Guraner J, Barteltt J, Zaki SR, Colley DG, Grijalva MJ, Powell MR. Mouse model for Chagas disease: immunohistochemical distribution of different stages of Trypanosoma cruzi in tissues throughout infection. Am J Trop Med Hyg 2001;65: 152-158.


    Whitney AE, Guarner J, Hutwagner L, Gold BD. Helicobacter pylori gastritis in children and adults: comparative histopathologic study. Ann Diagn Pathol 2000;4: 279-285.


    Torres J, Perez-Perez G, Goodman KJ, Atherton JC, Gold BD, Harris PR, Madrazo de la Garza A, Guarner J, Muñoz O. A comprehensive review of the natural history of Helicobacter pylori infection in children. Arch Med Res 2000;31: 431-469.


    Jensen B, Kepley W, Guarner J, Anderson K, Anderson D, Clairmont J, de l'Aune W, Austin EH, Austin GE. Comparison of polyvinyl alcohol fixative with three less hazardous fixatives for detection and identification of intestinal parasites. J Clin Microbiol 2000;38:1592-1598.


    Guarner J, Southwick K, Greer P, Bartlett J, Fears M, Santander A, Blanco S, Pope V, Levine W, Zaki S. Testing umbilical cords for funisitis due to Treponema pallidum infection, Bolivia. Emerg Infect Dis 2000;6: 487-492.


    Guarner J, Shieh WJ, Dawson J, Subbarao K, Shaw M, Ferebee T, Morken T, Nolte KB, Freifeld A, Cox N, Zaki SR. Immunohistochemical and in situ hybridization studies of influenza A virus infection in human lungs. Am J Clin Pathol 2000;114: 227-233.


    Guarner J, Herrera-Goepfert R, Mohar A, Sanchez L, Halperin D, Ley C, Parsonnet J. Interobserver variability in application of the revised Sydney classification for gastritis. Hum Pathol 1999;30: 1431-1434.


    Guarner J, Greer PW, Bartlett J, Chu MC, Shieh WJ, Zaki SR. Immunohistochemical detection of Francisella tularensis in formalin-fixed, paraffin-embedded tissue. Applied Immunohistochem Molec Morphol 1999;7: 122-126.


    Guarner J, Greer PW, Bartlett J, Ferebee T, Fears M, Pope V, Zaki SR. Congenital syphilis in a newborn: an immunopathologic study. Modern Pathol 1999;12: 82-87.


    Powell MR, Morgan J, Guarner J, Colley DG. Cytokine mRNA levels in the hearts of Inbred mice that develop different degrees of cardiomyopathy during infection with Trypanosoma cruzi. Parasit Immunol 1998;20: 463-471.


    Guarner J, Matilde-Nava T, Villasenor-Flores R, Sanchez-Mejorada G. Frequency of intestinal parasites in adult cancer patients in Mexico. Arch Med Res 1997;28: 219-222.


    Guarner J, Montoya P, del Rio C, Hernandez-Tepichin G. CD4+ T-lymphocyte variations in patients with advanced HIV infection and counts below 100 cells/ul. Cytomretry 1997;30: 178-180.


    Guarner J, Uribe-Zuniga P, Hernandez-Tepichin G, Teran-Toledo X, del Rio C. Comparison of CD4+ T-cell counts in men and women recently diagnosed with HIV infection in Mexico City, Mexico. AIDS 1997;11:17-18.


    del Rio C, Guarner J, Izazola-Licea JA. The use of oral fluid to determine HIV-1 prevalence rates among men in Mexico City. AIDS 1996;10: 233-235.


    Guarner J, Sanchez-Mejorada G, del Rio C, Mohar A. Simplified CD4+ T-lymphocyte count in patients with HIV/AIDS in Mexico. Salud Publica Mex 1996;38: 207-211. (Spanish)


    Guarner J, Izazola JA, del Rio C. The problems when counting CD4 positive T-lymphocytes. Rev Invest Clin (Mex) 1994;46: 163-4. (Spanish)


    Guarner J, Mohar A, Parsonnet J, Halperin D. The association of Helicobacter pylori with gastric cancer and preneoplasic gastric lesions in Chiapas, Mexico. Cancer 1993;71:297-301.


    Guarner J, del Rio C, Carr D, Hendrix LE, Eley JW, Unger ER. Non-Hodgkin's lymphomas in patients with human immunodeficiency virus infection. Presence of Epstein-Barr virus by in situ hybridization, clinical presentation, and follow-up. Cancer 1991;68: 2460-5.


    Guarner J, Unger ER. Association of Epstein-Barr virus in epithelioid angiomatosis of AIDS patients. Am J Surg Pathol 1990;14: 956-60.


    Guarner J, del Rio C, Hendrix L, Unger ER. Composite Hodgkin's and non-Hodgkin's lymphoma in a patient with AIDS. Cancer 1990;66: 796-800.


    Guarner J, Cohen C, DeRose PB. Histogenesis of extramammary and mammary Paget cells. An immunohistochemical study. Am J Dermatopathol 1989;11: 313-8.


    Guarner J, Brynes RK, Chan WC, Birdsong G, Hertzler G. Primary non-Hodgkin's lymphoma of the heart in two patients with the acquired immunodeficiency syndrome. Arch Pathol Lab Med 1987;111: 254-6.


    Guarner J, Robey SS, Gupta PK. Cytologic detection of Pneumocystis carinii: A comparison of papanicolau and other histochemical stains. Diagn Cytopathol 1986;2: 133-7.


    Guarner J, del Rio C, Slade B. Tuberculosis as a manifestation of the acquired immunodeficiency syndrome. JAMA 1986;256: 3092.


    Book Chapters -

    Guarner J, del Rio C. Pathology, diagnosis, and treatment of anthrax in humans. In: NH Bergman. Bacillus anthracis and anthrax. Wiley-Blackwell, Inc. Hoboken, NJ. 2011 Chapter13 pages251-268.


    Guarner J. The spectrum of gastric disease associated with Helicobacter pylori and other infectious gastritides. Curr Gastroenterol Rep 2004; 6(6):441-6.


    Unger ER, Guarner J. Infectious diseases. In: Leonard DGB. Diagnostic molecular pathology. WB Saunders Co. Philadelphia, PA, p: 129-141, 2003.


    Nolte KB, Guarner J, Shieh WJ, Zaki SR. Emerging infectious diseases and the forensic pathologist. In: Froede RC, Davis GJ, Prahlow JA, Randall BB, Reay DT, Weedn VW (Eds). Handbook of forensic pathology. College of American Pathologists, Northfield, IL, chapter 36, pages: 345-360, 2003.


    King CH, Ashford DA, Dobos KM, Spotts Whitney EA, Raghunathan PL, Guarner J, Tappero JW. Mycobacterium ulcerans infection and Buruli ulcer disease: emergence of a public health dilemma. In: Scheld WM, Craig WA, Hughes JM. Emerging infections 5. ASM Press, Washington, D.C. P: 137-152; 2001.


    Slutsker L, Guarner J, Griffin P. Escherichia coli O157: H7. In: Nelson A, Horsburgh R. Pathology of Emerging Infections 2. 1st edition. American Society for Microbiology Press. Washington DC, U.S.A. 1998.


    Other Publications -

    Guarner J, Duncan A, Nelson AM, Messele T. Laboratory quality control for all, can this be achieved? Am J Clin Pathol 2012;138:639-41.


    Guarner J. Diagnosis of Malaria. Pathol Case Rev 2011;16: 242-245.


    Guarner J, Falcon-Escobedo R. Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses. Arch Med Res 2010;40:655-661 Epub Jan 2010.


    C Del Rio C, J Guarner. The 2009 influenza A (H1N1) pandemic: What have we learned in the past 6 months. Trans Am Clin Climatol Assoc. 2010;121:128-40.


    Nolte KD, Hanzlick RL, Payne DC, Kroger AT, Oliver WR, Baker AM, Mc Gowan DE, DeJong JL, Bell MR, Guarner J, Shieh WJ, Zaki SR. Medical examiners, coroners, and biologic terrorism: A guidebook for surveillance and case management. MMWR Recomm Rep. 2004;53(Rr-8):1-36.


    Guarner J, Mohar A. The asociation between Helicobacter pylori and gastric neoplasias: epidemiological evidence. Rev Gastroenterol Mex 2000;65: S20-S24. (Spanish)