Pathology Faculty Member

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  • Contact Information:

    Anatomic Pathology
    G144A EUH
    Atlanta, GA 30322
    404 712-7005 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Cynthia Cohen, MD

    Surgical Pathology
    Immunohistochemistry

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Director, Immunohistochemistry & Image Cytometry, Emory University Hospital


    Pathology Division(s):
    Anatomic Pathology


    Email Address:
    ccohe01@emory.edu


    Education:

      Convent Belgravia of the Sacred Heart; Johannesburg, South Africa: Joint Matriculation Board First Class with Distinction, - 1958

    E.C.F.M.G.   Certification No. 073-616-5, - 1964

    M.D.   University of the Witwatersrand Medical School, Johannesburg, South Africa, - 1964



    Research Interests:

    - Clinically applied research in immunohistochemistry and image cytometry
    My current interests involve the study of expression of diagnostic, prognostic , and therapeutic predictive markers.This includes the use of rabbit monoclonal antibodies in breast carcinoma,in situ hybridization for cytomegalovirus, EBV-encoded RNA, and immunoglobulin light chain restriction, a panel of tumor markers in triple negative breast carcinoma, and EGFRvIII in glioblastoma multiforme.


    - Translational research
    I collaborate with basic researchers in nanotechnology on breast cancers, and in melanoma and ovarian and pancreatic carcinoma, providing immunohistochemistry services.



    Clinical Focus:

    I am the Director of Immunohistochemistry and Image Cytometry. My clinical focus is on General Surgical Pathology with specialization in immunohistochemical assessment and quantitation of diagnostic, prognostic, and predictive markers in tumors. I participate in Surgical Pathology Resident and Fellow teaching, including their involvement in clinical research projects.


    Honors / Awards:

    Medical Student Research Day: Williams DJ, Cohen C, To TV, Lawson D, Sussman ZM, Nassar A. Triple negative breast carcinoma in women from Vietnam and the United States: characterization of differential marker expression by tissue microarray, platform presentation, Emory University, Atlanta, Georgia, January 30, 2008., 2008

    Stowell-Orbison Autopsy and Surgical Pathology Awards Competition. Yaar R, Page A, Hestley A, Delman K, Carlson GW, Cohen C. Clinical significance of morphometric measurements of melanoma metastatic to single sentinel lymph nodes. 97th Annual Meeting of United States and Canadian Academy of Pathology, Denver, Colorado, March, 1-7, 2008., 2008

    Excellence in Urological Pathology Resident Research Award, 94th Annual Meeting of the United States and Canadian Academy of Pathology, International Society of Urological Pathology, San Antonio, TX, 2005

    The International Society of Urologic Pathology (ISUP) Consensus Conference on Gleason Grading, San Antonio, Texas

    , 2005

    Internal Advisor, Prostate Cancer Research Program, Director: Leland WK Chung, Ph.D., Winship Cancer Institute, Atlanta, Georgia, 2003 to present

    Excellence in Urological Pathology Resident Research Award, 91st Annual Meeting of the United States and Canadian Academy of Pathology. International Society of Urological Pathology, Chicago, Illinois, 2002

    Certificate of Merit, Stowell-Orbison Award Competition for Pathologists- in training, 89th Annual Meeting of the United States and Canadian Academy of Pathology, New Orleans, Louisiana, 2000

    Golden Apple Award for Resident Education. Emory University School of Medicine, Department of Pathology, Atlanta, Georgia, 1997-1998

    Young Investigator Award, 12th Annual Clinical Application of Cytometry Meeting, Charleston, South Carolina, 1997

    Winner of ASCP/CAP Anatomic Pathology Residency Award, American Society of Clinical Pathologists/College of American Pathologists, Washington, District of Columbia

    , 1994

    Commendation Stowell Orbison Award for Excellence in Research, 83rd Annual Meeting of The United States and Canadian Academy of Pathology, San Francisco, California, 1994

    Stowell Orbison Award for Excellence in Research, 83rd Annual Meeting of The United States and Canadian Academy of Pathology, San Francisco, California

    , 1994

    Resident Clinical Award, Society of Head and Neck Surgeons and the European Organization for Research and Treatment of Cancer (EORTC), Paris, France

    , 1994

    Specialty Boards:

    1980 MD Anatomic Pathology


    1981 MD Dematopathology


    Other Publications -

    Kraus TS, Cohen C (2009): Expression of estrogen receptor beta and BRCA 1 in male and female breast cancer. Modern Pathology; 22 (Suppl 1): 51A.


    El-Sibai M, Cohen C, Nassar A, Siddiqui MT (2009): Predictive markers in primary breast cancer compared with lymph node and blood spread metastases. Modern Pathology; 22 (Suppl 1): 38A.


    Nassar A, Giorgadze TA, Cohen C (2009): Diagnostic utility of SNAIL in metaplastic breast carcinoma. Modern Pathology; 22 (Suppl 1): 58A.


    Toscano M, Cohen C, Hunter SB (2009): Eptein-Barr virus in multiple sclerosis. Modern Pathology; 22 (Suppl 1): 335A.


    Darrow MD, Cohen C, Nassar A (2009): Predictive markers (ER, PR, HER2, HER2 FISH) pre- and post- neoadjuvant chemotherapy in primary breast cancer. Modern Pathology; 22 (Suppl 1): 36A.


    Lauer S, Yaar R, Page A, Hestley A, Delman K, Carlson G, Cohen C (2009): Percentage of sentinel lymph node involvement by metastatic melanoma as measured by ACIS cytometric image analysis is associated with survival. Modern Pathology; 22 (Suppl 1): 105A.


    Janapureddy SR, Cohen C, Lau S, Beitler JJ, Siddiqui M (2009): Determination of oropharyngeal or nasopharyngeal squamous cell carcinoma primary site from fine needle aspiration of cervical lymph node metastases. Modern Pathology; 22 (Suppl 1): 86A.


    Devanath A, Parkos C, Li C, Cohen C, Liang H (2009): Junctional adhesion molecule-A expression in Crohn's disease and ulcerative colitis. Modern Pathology; 22 (Suppl 1): 128A.


    Busch R, Cohen C, Pambuccian SE, Gomez R, O'Regan R, Yang L, Gulbahce HE, Oprea-Ilies GM (2009): Clinicopathologic characteristics in correlation with protein expression profile in triple negative breast cancer in our population. Modern Pathology; 22 (Suppl 1): 32A.


    Lauer S, Oprea-Ilies GM, Adams A, Cohen C, Adsay NV (2009): Acidophil nuclear inclusions are fairly specific for florid duct hyperplasia among proliferative breast lesions. Modern Pathology; 22 (Suppl 1): 53A.


    Webber BA, Cohen C (2009): Automated double immunoenzymatic and colorimetric in-situ hybridization techniques in evaluation of immunoglobulin light chain expression. Modern Pathology; 22 (Suppl 1): 390 A.


    Jani J, Cohen C, Jehnazeb K, Lawson D, Osunkoya AO (2009): Neuroendocrine, proliferative and apoptotic markers in prostatic adenocarcinoma and small cell carcinoma of the prostate: a tissue microarray analysis of 64 cases. Modern Pathology; 22 (Suppl 1): 174A.


    Norton CM, Cohen C, Lawson D, Nassar A (2008): Image cytometric validation of breast carcinoma markers using tissue microarrays; rabbit monoclonal versus FDA-approved antibodies. Modern Pathology; 21 (Suppl 1): 368A.


    Schuetz AN, Cohen C (2008): Aspergillus and Candida immunohistochemistry of culture-confirmed fungal tissue isolates show high cross-reactivity. Modern Pathology; 21 (Suppl 1): 289A.


    Hanley KZ, Siddiqui MT, Lawson D, Cohen C, Nassar A (2008): Rabbit monoclonal antibodies in detection of ER, PR, and Her-2 in breast carcinoma cell block sections using conventional microscopy and quantitive image analysis. Modern Pathology; 21 (Suppl 1): 74A


    Smith SL, Adsay NV, Cohen C, Epstein JI, Osunkoya AO (2008): MUC2 expression in primary mucinous and nonmucinous adencarcnoma of the prostate; an analysis of 50 cases on radical prostatectomy. Modern Pathology; 21 (Suppl 1): 182A.


    Lim MG, Arbiser JB, Lawson D, Shou C, Chang XJ, Stein IM, Muller S, Cohen C (2008): PRL-3 protein expression in sinonasal and cutaneous melanoma. Modern Pathology; 21 (Suppl 1): 97A.


    Nassar A, Cohen C, Siddiqui MT, Albitar M, Agersborg SS, Zhou W, Lynch KA, Heyman ER, Olson AH, Lange H (2008): Reading digital IHC slides on a computer monitor-a multisite performance study using 180 HER2 stained breast specimens. Modern Pathology; 21 (Suppl 1): 367A.


    Nassar A, Siddiqui MT, Cohen C, Agerborg SS, Zhou W, Lynch KA, Albitar M, Vanderbilt BL, Barker EA, Lange H, Thompson J, Heyman ER, Olson A (2008): Trainable IHC Her2 image analysis system for Dako's HercepTest and Ventanas Pathway HER2- a multisite performance study using 260 breast tissue specimens. Modern Pathology; 21 (Suppl 1): 367A.


    Young AN, Cohen C, Lawson D, Picken MM, Amin MB, Osunkoya AO (2008): Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma. Modern Pathology; 21 (Suppl 1): 192A.


    Yaar R, Page A, Hestley A, Delman K, Carlson GW, Cohen C (2008): Clinical significance of morphometric measurements of melanoma metastatic to single sentinel lymph nodes. Modern Pathology; 21 (Suppl 1): 104A.


    Hornaman K, Cohen C, Siddiqui MT (2008): Detecting high grade cervical disease as ASC-H cytology: role of ProEx┬┐C and hr-HPV testing. Modern Pathology; 21 (Suppl 1): 74A.


    Lim MG, Lawson D, Cotsonis G, Chang XJ, Shou C, Stein IM, Cohen C (2008): PRL-3 expression-possible prognostic and predictive marker in primary cutaneous melanoma. Modern Pathology; 21 (Suppl 1): 97A


    Nassar A, Cohen C, Siddiqui MT (2007): Utility of glypican-3 and survivin in differentiating hepatocellular carcinoma (HCC) from other benign and preneoplastic hepatic lesions and metastatic adenocarcinomas in liver fine needle aspirate biopsies (FNAB). Cancer Cytopathology; 111 (Supp l): 417-418.


    Nassar A, Cohen C (2007): Validation of monoclonal rabbit antibodies (ER/PR/Her-2/MIB-1) in breast carcinoma. Cancer Cytopathology; 111 (Supp 1):


    Salih Z, Cohen C, Nassar A. (2007): Validation of rabbit monoclonal antibodies (ER/PR/Her-2, MIB-1) in breast carcinoma. Modern Pathology; 20: 49A; Laboratory Investigation; 87 (Supp1): 49A .


    Webber BA, Cohen C. (2007): Evaluation of in situ hybridization as a means of assessing immunoglobulin light chain restriction in plasma cell and B cell neoplasia. Modern Pathology; 20: 356A; Laboratory Investigation; 87 (Suppl 1): 356A.


    Moreira RK, Cohen C, Nolte FS. (2007) Gastrointestinal CMV disease: plasma viral load, in situ hybridization, immunohistochemistry, and clinicopathologic findings. Modern Pathology; 20: 123A; Laboratory Investigation; 87 (Suppl 1): 123A.


    Fanaian NK, Cohen C, Waldrop S, Wang J, Shehata B. (2007): Automated EBV-encoded RNA (EBER) in situ hybridization (ISH) and immunohistochemistry compared to manual ISH for detection of Epstein-Barr Virus (EBV) in pediatric lymphoproliferative disorders. Modern Pathology; 20: 312A; Laboratory Investigation; 87 (Suppl 1): 312A


    Homan SM, Cano O, Alpin A, Cohen C, Carlson JA. (2007): Overexpression of focal adhesion kinase in primary cutaneous melanoma. Modern Patholgy; 20: 94A; Laboratory Investigation; 87 (Suppl 1): 94A.


    Siddiqui MT, Cohen C. (2007): The utility of SMAD4 as diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors. Modern Pathology; 20: 84A; Laboratory Investigation; 87 (Suppl 1):84A.


    Sussman ZM, Cohen C, Haun P, Lawson D, Nassar A. (2007) Inference of the basal epithelial phenotype in breast carcinoma from differential marker expression, using tissue microarrays. Modern Pathology; 20: 51A; Laboratory Investigation; 87 (Suppl 1): 51A.


    Lu DY, Waldrop SM, Cohen C. (2007): Automated in situ hybridization and immunohistochemistry for cytomegalovirus detection in paraffin-embedded tissue sections. Modern Pathology; 20: 152A; Laboratory Investigation; 87 (Suppl 1): 152A.


    Coleman KE, Brat DJ, Cotsonis GA, Lawson D, Cohen C (2006): Proliferation (MIB expression) in oligodendrogliomas: assessment of quantitative methods and prognostic significance. Applied Immunohistochemistry and Molecular Morphology;109-114.


    Johnson EI, Beach RA, Waldrop SM, Lawson D, Cohen C (2006): Rapid intraoperative immunohistochemical evaluation of sentinel lymph nodes for metastatic breast carcinoma. Applied Immunohistochemistry and Molecular Morphology;14:57-62.


    McEachin MD, Xu X-X, Cotsonis G, Lawson D, Cohen C (2006): GATA-4 and GATA-6 expression in ovarian surface epithelial neoplasms. Applied Immunohistochemistry and Molecular Morphology; (In Press).


    Webber BA, Setzer SV, Poole GC, Lawson D, Cohen C (2006): Maspin and mutant p53 expression in malignant melanoma and other carcinomas: use of tissue microarray. Applied Immunohistochemistry and Molecular Morphology; (In Press).


    Zapata M, Cohen C, Siddiqui MT. (2006): Immunohistochemical expression of SMAD4, CK19, and CA 19-9 in fine needle aspiration samples of pancreatic adenocarcinoma: Utility and potential role. Cancer (Cancer Cytopathology); 108 (Suppl): 405.


    Nassar A, Cohen C, Siddiqui MIT. (2006): Utility of Millipore filter and cell block in thyroid needle aspirates: which method is more superior? Cancer (Cancer Cytopathology); 108 (Suppl): 434.


    Nassar A, Cohen C, O'Reilly K, Siddiqui MT. (2006): CINtec" assay for detection of p16INK4A and HPV DNA hybrid capture II test in Surepath" specimens: Correlation with biopsy follow-up results. Cancer (Cancer Cytopathology);108 (Suppl): 385.


    Nassar A, Cohen C, Tighiourat M, Vertino P. (2006): TMS1 immunohistochemical expression in ductal carcinoma in situ of the breast: Correlations with tumor characteristics and outcome. Modern Pathology; 19 (Suppl 3):18.


    Nassar A, Tighiourat M, Cohen C. (2006): Sentinel node status and tumor characteristics: A study of invasive lobular and mixed invasive lobular and ductal carcinoma. Modern Pathology;19 (Suppl 3):18.


    Radhakrishnan A, Nassar A, Lewis M, Phillips C, Cohen. (2006): Her2/neu expression (IHC), amplification (FISH), and chromosome 17 aneuploidy in invasive lobular carcinoma. Modern Pathology; 19:39A.


    Radhakrishnan A, Nassar A, Lewis M, Phillips C, Cohen C. (2006): Correlation of Her2/neu Overexpression (IHC) with gene amplification (FISH), and its relation to chromosome 17 aneuploidy: A 5 year experience with invasive ductal carcinoma. Modern Pathology; 19:40A.


    O'Reilly K, Cohen C, Radhakrishnan A, Siddiqui MT, Nassar A. (2006): A comparison between immunocytochemical staining of pap tests with p16 INK4A and high-risk HPV results: A Review of 70 cases. Modern Pathology; 19:68A.


    O'Reilly K, Cohen C, Radhakrishnan A, Siddiqui MT, Nassar A. (2006): A comparison between immunocytochemical staining of pap tests with p16 INK4A and high-risk HPV results: A Review of 70 cases. Modern Pathology; 19:68A.


    Hornsby CD, Bernstein K, Arbiser JL, Cotsonis G, Perry B, Cohen C. (2006). ACE expression in primary melanoma: Correlation with prognostic parameters and outcome. Modern Pathology; 19:81A.


    Kuehn A, Cohen C, Radhahrishnan, Shehata B, Datta M, Panner G, Amin MB, Srigley JR. (2006): Expression of Kidney-Specific Cadherin (Ksp-cad in rare and unusual renal epithelial neoplasms (REN). Diagnostic and Histogenetic Implications. Modern Pathology; 19: 145A.


    Choi WWL, Lewis MM Lawson D, Yin-Goen Q, Birdsong GG, Cotsonis GA, Cohen C, Young AN (2005): Angiogenic and lymphangiogenic microvessel density in breast carcinoma: Correlation with clinicopathologic parameters and VEGF-family gene expression. Modern Pathology; 18:143-152.


    Carlson GW, Murray DR, Lyles RH, Hestley A, Cohen C (2005): Sentinel lymph node biopsy in the management of cutaneous head and neck melanoma. Plastic and Reconstructive Surgery; 115:721-728.


    Nassar A, Amin MB, Sexton D, Cohen C (2005): Utility of alpha methylacyl coenzyme A racemase (p504S antibody) as a diagnostic immunohistochemical marker for cancer. Applied Immunohistochemistry and Molecular Morphology; 13:252-255.


    Hammock L, Carlson J, Carlson G, Murray D, Ross J, Nazir T, Sheehan C, Cohen C (2005): Use of chromogenic in-situ hybridization (CISH) to determine loss of melastatin expression in sentinel lymph node (SLN)- negative malignant melanoma with subsequent metastases. Journal of Cutaneous Pathology, (In Press).


    Badr KM, Nolen JDL, DeRose PB, Cohen C (2004): Muscle invasive schistosomal squamous cell carcinoma of the urinary bladder: frequency and prognostic significance of p53, bcl-2, HER2/neu and proliferation (MIB-1). Human Pathology; 35:184-189.


    Gal AA, Sheppard MN, Nolen JDL, Cohen C (2004): p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. Modern Pathology; 17:33-39.


    Varma VJ, Cohen C (2004): Immunohistochemical and molecular markers in the diagnosis of hepatocellular carcinoma. Advances in Anatomic Pathology; 11:239-249.


    Kelavkar UP, Cohen C (2004): 15-lipoxygenase-1 expression upregulates and activates insulin-like growth factor-1 receptor in prostate cancer cells. Neoplasia 6; 41-52.


    Fields AC, Cotsonis G, Sexton DG, Santoianni R, Cohen C (2004): Survivin expression in hepatocellular carcinoma: correlation with proliferation and prognosis. Modern Pathology; 17:1378-1385.


    Eudy GE, Carlson GW, Murray DR, Waldrop SM, Lawson D, Cohen C (2003): Rapid immunohistochemistry of sentinel lymph nodes for malignant melanoma. Human Pathology; 34:797-802.


    Hammock L, Phillips C, Lewis M, Cohen C (2003): Strong Her-2/neu protein overexpression by immunohistochemistry does not predict oncogene amplification by fluorescence in situ hybridization. Human Pathology; 34:1043-1047.


    Cohen C, Lohmann CM, Cotsonis G, Lawson D, Santoianni R (2003): Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis. Modern Pathology; 16:574-583.


    Bell J, Walsh S, Nusrat A, Cohen C (2003): Zonula occludens and HER-2/neu expression in invasive breast carcinoma. Applied Immunohistochemistry and Molecular Morphology; 11:125-129.


    Carlson GW, Murray DR, Lyles RH, Staley CA, Hestley A, Cohen C (2003): The amount of metastatic melanoma in a sentinel lymph node: does it have prognostic significance? Annals of Surgical Oncology; 10:575-581.


    Carlson GW, Murray DR, Hestley A, Staley CA, Lyles RH, Cohen C (2003): Sentinel lymph node mapping for thick (>/=4-mm) melanoma: should we be doing it? Annals of Surgical Oncology; 10:408-415.


    Beach RA, Lawson D, Waldrop SM, Cohen C (2003): Rapid immunochemistry for cytokeratin in the intraoperative evaluation of sentinel lymph nodes for metastatic breast carcinoma. Applied Immunohistochemistry and Molecular Morphology; 11:45-50.


    Schiller AB, Clark WS, Cotsonis G, Lawson D, Cohen C (2002): Image cytometric bcl-2: bax and bcl-2:bcl-x ratios in invasive breast carcinoma: correlation with prognosis. Cytometry: Communications in Clinical Cytometry; 50:203-209.


    Carlson GW, Murray DR, Thourani V, Hestley A, Cohen C (2002): The definition of the sentinel lymph node in melanoma based on radioactive counts. Annals of Surgical Oncology; 9:929-933.


    Cohen C, Zavala-Pompa A, Sequeira JH, Shoji M, Sexton DG, Cotsonis G, Cerimele F, Govindarajan B, Macaron N, Arbiser JL (2002): Mitogen-actived protein kinase activation is an early event in melanoma progression. Clinical Cancer Research; 8:3728-3733.


    Garcia EJ, Lawson D, Cotsonis G, Cohen C (2002): Hepatocellular carcinoma (HCC) and markers of apoptosis (bcl-2, bax and bcl-x): prognostic significance. Applied Immunohistochemistry and Molecular Morphology; 10:210-217.


    Cohen C, Alazraki NP, Styblo T, Waldrop SM, Grant SF, Larsen T (2002): Immunohistochemical evaluation of sentinal lymph nodes in breast carcinoma patients. Applied Immunohistochemistry and Molecular Morphology; 10:296-303.


    Middleman BR, Friedman M, Lawson D, DeRose PB, Cohen C (2002): Melanoma growth stimulatory activity in primary malignant melanoma; prognostic significance. Modern Pathology; 15:532-537.


    Kenny-Moynihan MB, Gal AA, Chakraborty H, DeRose PB, Cohen C (2001): DNA cytometry in thymic neoplasms; a comparison between flow and image cytometry and correlation with clinical outcome. Analytical and Quantitative Cytology and Histology; 23:313-320.


    Lohmann C, Gibney E, Cotsonis G, Lawson D, Cohen C (2001): Progesterone receptor immunohistochemical quantitation compared to cytosolic assay; correlation with prognosis in breast cancer. Applied Immunohistochemistry; 9:49-53.


    Arbiser JL, Weiss SW, Arbiser ZK, Bravo F, Govindajaran B, Caceres-Rios H, Cotsonis G, Recavarren S, Swerlick RA, Cohen C (2001): Differential expression of active mitogen-activated protein kinase in endothelial neoplasms; implications for biologic behavior and response to therapy. Journal of the American Academy of Dermatology; 44:193-197.


    Mosunjac MB, Lewis MM, Lawson D, Cohen C (2000): Use of a novel marker-Calponin, for myoepithelial cells in fine needle aspirates of papillary breast lesions. Diagnostic cytopathology; 23:151-155.