Goetz Ehrhardt, PhD

Immunology

Assistant Professor
Pathology & Laboratory Medicine

Pathology Division(s):
Experimental Pathology

Email Address:
rehrhar@emory.edu

Education:

M.Sc.   The Weizmann Institute of Science, Rehovot, Israel, 1994 - 1996

Ph.D.   The University of British Columbia, Vancouver, Canada, 1996 - 2001

Research Interests:

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Our research focuses on the analysis of a novel family of immunoglobulin-domain containing cell surface receptors (FCRL) with B cell specific expression pattern and on the cells characterized by their expression. The intracellular domains of these receptors contain immunoreceptor tyrosine-based inhibitory motifs (ITIM) and/or immunoreceptor tyrosine-based activation motifs (ITAM). Biochemical analysis of the intracellular domains of several of the FCRL-family members indicates a strong immunoregulatory potential. We are interested in the effects of dysregulation of various FCRL-family members on B cell responses as well as their potential involvement in B cell disorders. A second area of interest centers on the identification of novel biomarkers using the recently identified lamprey VLR antibodies.

Selected Publications:

Published and Accepted Research Articles -

Ehrhardt GR, Hijikata A, Kitamura H, Ohara O, Wang JY, Cooper MD. Discriminating gene expression profiles of memory B cell subpopulations. J Exp Med. 2008 Aug 4;205(8):1807-17

Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5

Haga CL, Ehrhardt GR, Boohaker RJ, Davis RS, Cooper MD. Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9770-5

Ehrhardt GR, Hsu JT, Gartland L, Leu CM, Zhang S, Davis RS, Cooper MD. Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. J Exp Med. 2005 Sep 19;202(6):783-91

Pancer Z, Amemiya CT, Ehrhardt GR, Ceitlin J, Gartland GL, Cooper MD. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature. 2004 Jul 8;430(6996):174-80

Ehrhardt A, David MD, Ehrhardt GR, Schrader JW. Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen. Mol Cell Biol. 2004 Jul;24(14):6311-23

Ehrhardt GR, Davis RS, Hsu JT, Leu CM, Ehrhardt A, Cooper MD. The inhibitory potential of Fc receptor homolog 4 on memory B cells. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13489-94

Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW. A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth. Oncogene. 2001 Jan 11;20(2):188-97

Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW. M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. Blood. 1999 Oct 1;94(7):2433-44

Other Publications -

Ehrhardt GR, Leu CM, Zhang S, Aksu G, Jackson T, Haga C, Hsu JT, Schreeder DM, Davis RS, Cooper MD. Fc receptor-like proteins (FCRL): immunomodulators of B cell function. Adv Exp Med Biol. 2007;596:155-62

Davis RS, Ehrhardt GR, Leu CM, Hirano M, Cooper MD. An extended family of Fc receptor relatives. Eur J Immunol. 2005 Mar;35(3):674-80

Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW. Ras and relatives--job sharing and networking keep an old family together. Exp Hematol. 2002 Oct;30(10):1089-106