Pathology Faculty Member

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  • Contact Information:

    Grady Mem Hosp Clinical Laboratory Room D119
    80 Jesse Hill Jr Dr SE
    Atlanta, GA 30303
    404 616-4800 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Andrew N Young, MD, PhD

    Cancer Biology
    Clinical Pathology

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Director, Clinical Laboratories, Grady Memorial Hospital


    Pathology Division(s):
    Clinical Pathology
    Experimental Pathology


    Email Address:
    andrew.n.young@emory.edu


    Education:

    BA   Northwestern University, Evanston IL Chemistry/Biochemistry, 1981 - 1985

    MD/PhD   State University of New York-Buffalo, PhD: Molecular Immunology, Roswell Park Cancer Institute, 1985 - 1995

      Emory University, Atlanta, GA, Resident (AP/CP), Pathology & Laboratory Medicine, 1995 - 1998

      Emory University, Atlanta, GA Chief Resident Pathology & Laboratory Medicine, 1998 - 1999

      Emory University, Atlanta, GA, Fellow, Molecular Pathology, 1999 - 2000



    Research Interests:

    - Primary Focus - Molecular classification of kidney cancer by gene expression profiling.
    My research laboratory has developed systems for molecular classification of renal tumors using cDNA and oligonucleotide microarrays. Based on gene expression profiles, we have identified numerous immunohistochemical markers for diagnosis and clinical management. Currently, we are developing novel Raman-active nanoparticle-based immunoassays for renal tumor classification using fixed tissue and fluids.



    Clinical Focus:

    I am the Director of Clinical Laboratories at Grady Health System. Grady Memorial Hospital and its affiliated clinics make up one of the largest public health systems in the US. The laboratories play a vital role at Grady, supporting centers of excellence in infectious disease, emergency medicine, trauma, toxicology, stroke, sickle cell disease, oncology, and many other fields. In addition, the laboratories perform testing for most research studies conducted at Grady. Our department offers a broad menu of assays in all major disciplines, including clinical chemistry, toxicology, transfusion medicine, hematology, coagulation, flow cytometry, microbiology and molecular pathology. I provide diagnostic interpretation for hematopathology and hemoglobin analysis and, along with my faculty colleagues (Drs Koch, Shaz and Wang), train pathology residents from Emory University. Residents at Grady are exposed to a unique perspective on laboratory medicine, administration, and the role of clinical pathologists in a public healthcare setting.


    Honors / Awards:

    Avon Breast Cancer Research Scholarship Emory University School of Medicine, Winship Cancer Institute, 2000-2003

    NIH National Research Service Award Institutional Training Grant Emory University Department of Pathology & Laboratory Medicine, 1999-2000

    Gilbert D Moore Fellowship, Medical Scientist Training Program SUNY-Buffalo School of Medicine and Biomedical Sciences, 1985-1987

    Phi Beta Kappa Northwestern University Chapter, 1984

    Specialty Boards:

    2002  American Board of Pathology (Anatomic & Clinical Pathology)


    Selected Publications:

    Published and Accepted Research Articles -

    YOUNG AN, Dale J, Yin-Goen Q, Harris WB, Petros JA, Datta MW, Wang MD, Marshall FF, Amin MB. Current trends in molecular classification of adult renal tumors. Urology 2006; 67:873-880


    Paner GP, Srigley JR, Radhakrishnan A, Cohen C, Skinnider BF, Tickoo SK, YOUNG AN, Amin MB. Immunohistochemical Analysis of Mucinous Tubular and Spindle Cell Carcinoma and Papillary Renal Cell Carcinoma of the Kidney: Significant Immunophenotypic Overlap Warrants Diagnostic Caution. Am J Surg Pathol. 2006;30:13-19


    Tickoo SK, Deperalta-Venturina MN, Harik LR, Worcester HD, Salama ME, YOUNG AN, Moch H, Amin MB. Spectrum of Epithelial Neoplasms in End-Stage Renal Disease: An Experience From 66 Tumor-Bearing Kidneys With Emphasis on Histologic Patterns Distinct From Those in Sporadic Adult Renal Neoplasia. Am J Surg Pathol 2006; 30:141-153


    Yin-Goen Q, Dale J, Yang WL, Phan J, Moffitt R, Petros JA, Datta MW, Amin MB, Wang MD, YOUNG AN. Advances in molecular classification of renal neoplasms. Histol Histopathol. 2006; 21:325-39


    Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, YOUNG A, de Peralta-Venturina M, Amin MB. Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. Am J Surg Pathol 2005; 29:747-54


    Sheppard CA, Allen RC, Austin GE, YOUNG AN, Ribeiro MA, Fantz CR. Paraprotein interference in automated chemistry analyzers. Clin Chem 2005; 51:1077-8


    Schuetz AN, Yin-Goen Q, Amin MB, Moreno CS, Cohen C, Hornsby CD, Yang WL, Petros JA, Issa MM, Pattaras JG, Ogan K, Marshall FF, YOUNG AN. Molecular Classification of Renal Tumors by Gene Expression Profiling. J Mol Diagn 2005; 7:206-18


    Ramachandran, S, Liu P, YOUNG AN, Yin-Goen Q, Lim SD, Laycock N, Amin MB, Carney JK, Marshall FF, Petros JA, Moreno CS. Loss of HOXC6 Expression Induces Apoptosis in Prostate Cancer Cells. Oncogene 2005; 24:188-98


    Choi WWL, Lewis MM, Lawson D, Yin-Goen Q, Birdsong GG, Cotsonis GA, Cohen C, YOUNG AN. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. Mod Pathol 2005; 18:143-52


    Bouet R, Thwaites D, Harris SB, YOUNG AN, Issa MM. Asymptomatic follicular lymphoma of the prostate discovered by abnormal digital rectal examination. J Urol 2004; 171:795-6


    YOUNG AN, Salles PGO, Lim SD, Cohen C, Petros JA, Marshall FF, Neish AS, Amin MB. Beta Defensin-1, Parvalbumin and Vimentin: A Panel of Diagnostic Immunohistochemical Markers for Renal Tumors Derived from Gene Expression Profiling Studies using cDNA Microarrays. Am J Surg Pathol 2003; 27:199-205


    Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, Amin MB, YOUNG AN, Ganz TA, Marshall FF, Petros JA. Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Lab Invest 2003; 83:501-5


    Gewirtz AT, Collier-Hyams LS, YOUNG AN, Kucharzik T, Guilford W, Parkinson J, Williams IR, Neish AS, and Madara JL. Lipoxin A4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 2002; 168:5260-7


    Hunter S, YOUNG A, Olson J, Brat DJ, Bowers G, Wilcox JN, Jaye D, Mendrinos S, Neish A. Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. J Neuropathol Exp Neurol 2002; 61:275-81


    Boss V, Roback JD, YOUNG AN, Roback LJ, Vogt-Weisenhorn DM, Medina-Flores R, Wainer BH. Nerve growth factor, but not epidermal growth factor, increases Fra-2 expression and alters Fra-2/JunD binding to AP-1 and CREB binding elements in pheochromocytoma (PC12) cells. J Neurosci 2001; 21:18-26


    YOUNG AN, Amin MB, Lim SD, Cohen C, Petros JA, Marshall FF, Neish AS (2001). Expression Profiling of Renal Epithelial Neoplasms: A Method for Tumor Classification and Discovery of Diagnostic Molecular Markers. Am J Pathol 2001; 158:1639-51


    Evans CO, YOUNG AN, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku NM. Novel patterns of gene expression in pituitary adenomas identified by cDNA microarrays and quantitative RT-PCR. J Clin Endocrinol Metab 2001; 86:3097-107


    Neish AS, Gewirtz AT, Zeng H, YOUNG AN, Hobert M, Karmali V, Rao AS, Madara JL. Prokaryotes regulate epithelial responses by inhibition of IkB-alpha ubiquitination. Science 2000; 289:1560-63