Pathology Faculty Member

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    Clinical and Experimental Pathology
    1364 Clifton Rd. N.E. Rm. D-655
    Atlanta, GA 30322
    404 712-5869 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    John D Roback, MD, PhD

    Transfusion Medicine

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Medical Director, Emory University Hospital, Blood Bank

    Director, Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine

    Medical Director, Emory Medical Laboratories

    Vice-Chair for Clinical Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine

    Medical Director, Emory Healthcare School of Medical Technology


    Pathology Division(s):
    Clinical Pathology
    Experimental Pathology


    Email Address:
    jroback@emory.edu


    Education:

    Bachelor   Biophysics,The Johns Hopkins University, Baltimore, MD, 1980 - 1984

    Medical Doctor   The University of Chicago, Chicago, IL, - 1994

    Doctorate   Experimental Pathology, The University of Chicago, Chicago, IL, 1984 - 1994



    Research Interests:

    - Overview
    I) Metabolomic phenotyping of RBC units during prestorage transfusion to support the development and validation of metabolic biomarkers, RBC storage limits, and optimized storage approaches that can be used to improve transfusion efficacy. II) Identification of vascular effects of stored RBCs in vitro and in vivo to better understand potential adverse consequences of transfusions on recipient outcomes. III) Dissection of mechanisms underlying antibody responses to transfused RBCs in order to develop approaches to prevent and/or manage RBC allo-immunization. IV) Approaches to prevent transfusion-transmitted CMV infections. And, V) other work in transfusion including development and validation of novel blood typing instruments and development of transfusion clinical practice guidelines



    Clinical Focus:

    Improving the safety and efficacy of blood transfusion and hematopoietic stem cell transplantation. Current positions: Professor (tenured) in the Department of Pathology and Laboratory Medicine, Director of the Emory Center for Transfusion and Cellular Therapies, Director of the Emory University Hospital Blood Bank, and Director of the Stem Cell Processing Laboratory at Emory University Hospital, Vice-Chair of Clinical Pathology, and Medical Director of Emory Medical Laboratories. National leadership positions: Co-Chairman of the NIH/NHLBI Global Blood Safety and Availability Strategic Planning Committee, Chairman of the AABB Clinical Transfusion Medicine Committee, and Editor of the AABB Technical Manual.


    Honors / Awards:

    AABB President's Award, 2017

    Golden Apple Teaching Award, 2002-2003

    New Enterprise Award (1st place out of 70 entries), 2001

    National Blood Foundation Scholar, 2000

    Specialty Boards:

    2001  Diplomate, American Board of Pathology in Clinical Pathology


    2002  Diplomate, American Board of Pathology in Blood Banking and Transfusion Medicine


    Selected Publications:

    Published and Accepted Research Articles -

    . Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.


    Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.


    Ogawa, S., Szlam, F., Chen, E., Nishimura, T., Kim, H., Roback, J.D., Levy, J., Tanaka, K (2012) A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion. 52(1): 14-22.


    James, A.B., Josephson, C.D., Castillejo, M.I., Schreiber, G.B., and Roback, J.D. (2012) Epidemiological profiles of foreign-born and US-born Hispanic blood donors in a major metropolitan area in the United States. J. Blood Transfusion. 2012: ID 820514, 7 pages.


    James, A.B., Josephson, C.D., Castillejo, M.I., Schreiber, G.B., and Roback, J.D. (2012) Epidemiological profiles of foreign-born and US-born Hispanic blood donors in a major metropolitan area in the United States. J. Blood Transfusion. 2012: ID 820514, 7 pages.


    Murphy, E.L., Schlumpf, K., Wright, D., Cable, R., Roback, J.D., Sacher, R., and Busch, M.P. (2012) BMI and obesity in U.S. blood donors: A potential public health role for the blood centre. Public Health Nutrition. 15(6), 964-971.


    Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.


    Kleinman, S.H., Triulzi, D.J., Murphy, E.L., Carey, P.M., Gottschall, J.L., Roback, J.D., Carrick, J.D., Carrick, D., Mathew, S., Wright, D.J., Cable, R., Ness, P., Gajic, O., Hubmayr, R.D., Looney, M.R., and Kakaiya, R.M. (2011) The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 51(10): 2078-91.


    Roback, J.D., Neuman, R.B., Quyyumi, A., and Sutliff, R. (2011) Insufficient nitric oxide bioavailability: a hypothesis to explain the adverse effects of red blood cell transfusion. Transfusion. 51: 859-866.


    Hossain, M.S., Jaye, D.L., Pollack, B.P., Farris, A.B., Tselanyane, M.L., David, E., Roback, J.D., Gewirtz, A.T., and Waller, E.K. (2011) Flagellin, a TLR5 agonist, reduces GvHD in allogeneic HSCT recipients while enhancing anti-viral immunity. J. Immunol. 187(10): 5130-40.


    Rios, J.A., Schlumpf, K.S., Kakaiya, R.M., Triulzi, D.J., Roback, J.D., Kleinman, S.H., Busch, M.P., Gottschall, J.L., Carey, P.M., and Nemo, G.J. (2011) Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of allo-exposure. Transfusion. 51(6): 1197-206.


    Akhtari, M., Giver, C.R., Ali, Z., Flowers, C.R., Gleason, C.L., Hillyer, C.D., Kaufman, J., Khoury, H.J., Langston, A.A., Lechowicz, M.J., Lonial, S., Renfrow, H.M., Roback, J.D., Tighiouart, M., Vaughn, L., and Waller, E.K. (2010) Receiver operating curve analysis of circulating blood dendritic cell precursors and T-cells predicts response to extracorporeal photopheresis in patients with chronic graft-versus-host disease. Transfusion. 50(11): 2424-31.


    Murad, M.H., Stubbs, J.R., Gandhi, M.J., Wang, A.T., Paul, A., Erwin, P.J., Montori, V.M., and Roback, J.D. (2010) The effect of plasma transfusion on morbidity and mortality: A systematic review and meta-analysis.


    Roback, J.D., Caldwell, S., Carson, J., Davenport, R., Drew, M.J., Eder, A., Fung, M., Hamilton, M., Hess, J. Luban, N., Perkins, J., Sachais, B., Shander, A., Silverman, T., Snyder, E., Tormey, C., Waters, J., and Djulbegovic, B.


    Carrick, D.M., Johnson, B., Kleinman, S.H., Vorhaben, R., Chance, S.C., Lee, J.-H., Roback, J.D., Pandey, S., Sun, Y., Busch, M.P., and Norris, P.J. (2010) Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoff. Transfusion. 51(5): 1105-16.


    Onyeagocha, C., Hussein, S., Roback, J.D., and Gewirtz, A.T. (2009) Latent cytomegalovirus infection exacerbates experimental colitis. Am. J. Pathology. In press.


    Fowlkes. A.L., Brown, C., Amin, M.M., Roback, J.D., Downing, R., Nzaro, E., Mermin, J., Hladik, W., and Dollard, S.C. (2009) Quantitation of HHV-8 antibody in patients transfused with HHV-8 seropositive blood. Transfusion. In press.


    Djulbegovic, B., Trikalinos, T.A., Roback, J.D., Chen, R., and Guyatt, G. (2009) Impact of quality of evidence on the strength of recommendations: an empirical study. BMC Health Services Research. 9:120, 1-6.


    Hossain, M.S., Roback, J.D., and Waller, E.K (2008) Host and donor immune responses contribute to anti-viral effects of amotosalen-treated donor lymphocytes following early post-transplant CMV infection. J. Immunol. 180(10), 6892-902.


    Hendrickson, J.E, Roback, J.D., Hillyer, C.D., Easley, K.A., and Zimring, J.C (2008) Discrete toll like receptor agonists have differential effects on alloimmunization to transfused red blood cells. Transfusion. 48(9), 1869-77.


    Hendrickson, J.E, Chadwick, T.E., Roback, J.D., Hillyer, C.D., and Zimring, J.C (2007) Inflammation Enhances Consumption and Presentation of Transfused RBC Antigens by Dendritic Cells. Blood. 110(7), 2736-43.


    Hicks, M.L., Lonial, S., Langston, A., Flowers, C., Roback, J.D., Smith, K.J., Sai, S.M., Teagarden, D., Hamilton, E.S., and Waller, E.K. (2007) Optimizing the timing of chemotherapy for mobilizing autologous blood hematopoietic progenitor cells. Transfusion. 47(4), 629-35.


    Ninan, M.J., Flowers, C.R., Roback, J.D., Arellano, M.L., Waller, E.K. (2007) Post-transplant thrombopoiesis predicts survival in patients undergoing autologous hematopoietic progenitor cell transplantation. Biology of Blood and Marrow Transplantation. 13(8), 895-904.


    Hossain, M.S., Roback, J.D., Pollack, B.P., Jaye, D.L., Langston, A., and Waller, E.K (2007) Chronic GvHD decreases anti-viral immune responses in allogeneic BMT. Blood. 109(10), 4548- 4556.


    Zimring, J.C., Spitalnik, S.L., Roback, J.D., and Hillyer, C.D. (2007) Transfusion induced auto- antibodies and differential immunogenicity of blood group antigens: A novel hypothesis. Transfusion. 47(12), 2189-96.


    Roback, J.D., Conlan, M., Drew, W.L., Ljungman, P., Nichols, W.G., and Preiksaitis, J.K. (2006) The role of photochemical treatment with amotosalen and UV-A light in the prevention of transfusion-transmitted cytomegalovirus infections. Transf. Med. Rev. 20(1), 45-56.


    Hendrickson, J.E., Desmarets, M., Deshpande, S.S., Chadwick, T., Hillyer, C.D., Roback, J.D., and Zimring, J.C. (2006) Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells. Transfusion (in press).


    Roback, J.D., Su, L., Newman, J.L., Saakadze, N., Lezhava, L., and Hillyer, C.D. (2006) Transfusion-transmitted CMV infection in a murine model: Characterization of CMV-infected donor mice. Transfusion (in press).


    Zimring, J.C., Hair, G., Chadwick, T.E., Deshpande, S., Anderson, K., Hillyer, C.D., and Roback, J.D. (2005) Non-hemolytic antibody induced loss of erythrocyte surface antigen. Blood. 106(3), 1105-1112. [see accompanying editorial: Spitalnik, S.L. (2005) Yin and yang in transfusion medicine. Blood 106(3), 771-2]


    Sheppard, C.A., Roback, J.D., and Hillyer, C.D. (2005) Transfusion-transmitted cytomegalovirus infection: Consideration toward an optimal plan for its mitigation. Blood. Ther. Med. 5(1), 6-14.


    Schuetz, A.N., Kost, C., and Roback, J.D. (2005) Transfusion-transmitted Streptococcus pneumoniae from a single donor platelet apheresis unit. Journal of Clinical Apheresis. 20, 86-87.


    Hossain, M.S., Roback, J.D., Lezhava, L., Hillyer, C.D., and Waller, E.K. (2005) Amotosalen treated donor T-cells have polyclonal antigen specific long-term function without GvHD after allogeneic bone marrow transplantation. Biology of Blood and Marrow Transplantation. 11(3), 169-180.


    Roback, J.D., Caliendo, A.M., Newman, J.L., Sgan, S., Saakadze, N., Gillespie, T.W., Lane, T.A., Kurtzberg, J., and Hillyer, C.D. (2005) Comparison of CMV PCR and serology for screening umbilical cord blood components. Transfusion. 45(11), 1722-1728.


    Schuetz, A.N., Hillyer, K.L., Roback, J.D., Hillyer, C.D. (2004) Leukoreduction filtration of blood with sickle cell trait. Transf. Med. Rev. 18(3), 168-176.


    Roback, J.D., Barclay, S., and Hillyer, C.D. (2004) Improved methodology for fluorescence cytometric immunohematology testing. Transfusion. 44(2), 187-196.


    Zimring, J.C., Chadwick, T.E., Hillyer, C.D., and Roback, J.D. (2004) Effect of mediators of innate immunity and inflammation on CD8+ veto cells. Transplantation. 78(11), 1597-1600.


    Waller, E.K., Giver, C.R., Rosenthal, H., Somani, J., Langston, A., Lonial, S., Roback, J., Li, J.-M., Hossain, M.S., and Redei, I. (2004) Facilitating T-cell immune reconstitution after haplo-identical transplantation in adults. Blood Cells, Molecules and Diseases. 33(3), 233-237.


    Book Chapters -

    Roback, J.D. (2006) Human Herpesvirus Infections. In: Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).


    Roback, J.D. (2004) Preparation of Blood Components to Reduce CMV and Other Infectious Risks. In: Handbook of Pediatric Transfusion Medicine, pp. 93-99, Hillyer, C.D., Strauss, R., and Luban, N.L.C., eds., Academic Press, San Diego, CA.


    Books Edited and Written -

    Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).


    Other Publications -

    Mintz, P., Roback, J.D., (2005) Editorial: The National Blood Foundation: 20 years of supporting pioneering transfusion medicine research. Transfusion. 45(8S), i.