Department of Pathology and Laboratory Medicine
Emory University Hospital, room C179B
Atlanta, GA 30322
404 712-2805 Phone
Assistant Professor, Emory University School of Medicine
Hematopathology Service, Emory University
B.A. University of California at San Diego, La Jolla, CA, - 1985
M.D., M.A. Washington University School of Medicine, St. Louis, MO, - 1991
Residency Anatomic Pathology, Washington University School of Medicine, - 1995
Residency Clinical Pathology, University of Alabama, Birmingham, School of Medicine, - 1997
Fellowship Hematopathology, Emory University School of Medicine, - 1998
- Inflammation/ Hematopathology
I have 2 areas of ongoing investigation. One focus is a C-type lectin-family receptor (CD303) expressed uniquely on the surface of human plasmacytoid dendritic cells. Data suggest that this receptor impacts function of these cells in innate and adaptive immunity. We have developed unique biochemical tools to better understand the structure and function of CD303 including identification of natural binding targets whether of self or non-self origin. Specific efforts focus on identifying the specific counter-receptors on these targets and better characterizing the impact of receptor-ligand engagement. A second focus involves deciphering the role of the Bcl-6 interacting transcriptional co-repressor MTA3 and BCL6 in B cell lymphomas, work done in collaboration with Dr. P. Wade at NIEHS, and translating this knowledge into diagnostically useful tools.
I serve as an attending physician on the Hematopathology service at Emory University Hospital and as a consultant at Children's Healthcare of Atlanta. My clinical focus encompasses use of morphologic analysis, flow cytometric immunophenotyping, molecular diagnostic and fluorescence in situ hybridization/cytogenetics studies that are relevant to the subspecialty of hematopathology.
DOD Blood Cancer Review Panel, 2010
Ad Hoc Reviewer, NCI SPORE study section, 2004
Ad Hoc Reviewer, NIH/NCI IMAT study section, 2002-2003
Avon Breast Cancer Crusade Scholar, 2001-2003
CAP Foundation Scholars Award, 1999-2000
Phi Beta Kappa, University of California at San Diego, La Jolla, CA, 1985
1997 American Board of Pathology, Anatomic and Clinical Pathology
2004 American Board of Pathology, Hematology
Giver CR, Jaye DL, Waller EK, Kaufman JL, Lonial S. Rapid recovery from panobinostat (LBH589)-induced thrombocytopenia in mice involves a rebound effect of bone marrow megakaryocytes. Leukemia. In press, 2010.
Lai AY, Fatemi M, Dhasarathy A, Malone C, Sobol SE, Geigerman C, Jaye DL, Mav D, Shah R, Li L, Wade PA. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. The Journal of Experimental Medicine 2010; 207(9):1939-1950 PUBMED LINK.
Kraus TS, Sillings CN, Saxe DF, Li SY, Jaye DL. The Role of CD11c Expression in the Diagnosis of Mantle Cell Lymphoma. American Journal of Clinical Pathology, 2010; 134 (2):271-277 PUBMED LINK."
Akhtari M, Waller EK, Jaye DL, Lawson DH, Ibrahim R, Papadopoulos NE, Arellano ML: Neutropenia in a patient treated with ipilimumab (anti-CTLA-4 antibody), J Immunother 2009, 32:322-324
Choi WWL, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, Braziel RM, Iqbal J, Lenz G, Vose JM, Hans CP, Fu K, Smith LM, Li M, Liu Z, Geng H, Gascoyne RD, Rosenwald A, Rimsza L, Campo E, Jaffe ES, Jaye DL, Staudt LM, Chan WC. A New Immunostain Algorithm Classifies Diffuse Large B-cell Lymphoma into Molecular Subtypes with High Accuracy. Clinical Cancer Research 2009; 15:5494-502
Helbling Chadwick L, Chadwick BP, Jaye DL, Wade PA: The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells, Chromosoma 2009, 118:445-457
Karathanasis E, Geigerman CM, Parkos CA, Chan L, Bellamkonda RV, Jaye DL. Selective targeting of nanocarriers to neutrophils and monocytes. Annals of Biomedical Engineering. 2009; 37(10):1984
Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Ciccarelli B, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Lonial S, Richardson P, Munshi N, Anderson KC. Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Novel Therapeutic Target. Cancer Cell, 2009; 16(4):309-323.
Li JM, Southerland LT, Lu Y, Darlak KA, Giver CR, McMillin DW, Harris WAC, Jaye DL, Waller EK. Activation, Immune Polarization, and Graft-versus-Leukemia Activity of Donor T Cells Are Regulated by Specific Subsets of Donor Bone Marrow Antigen-Presenting Cells in Allogeneic Hemopoietic Stem Cell Transplantation. Journal of Immunology. 2009; 183 (12):7799-7809.
Agarwal A, Jaye DL, Giegerman CM, Bellamkonda RV: Rational identification of a novel peptide for targeting nanocarriers to 9L glioma, J Biomed Mater Res A 2008, 87A:728-738
Jaye DL, Iqbal J, Fujita N, Geigerman C, Li S, Karanam S, Fu K, Weisenberger DD, Chan WC, Moreno CS, Wade PA. The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. J. Pathology 2007; 213:106-115.
Hossain MS, Roback JD, Pollack BP, Jaye DL, Langston A, Waller EK. Chronic GvHD decreases anti-viral immune responses in allogeneic BMT. Blood 2007; 109: 4548-4556.
Jaye DL, Geigerman CM, Herling M, Eastburn K, Waller EK, Jones DM. Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+ CD56+ hematodermic neoplasms. Modern Pathology 2006; 19:1555-622.
Liu P, Ramachandran S, Seyed MA, Scharer CD, Laycock N, Dalton WB, Williams H, Karanam S, Datta MW, Jaye DL, Moreno CS. Sex-determining region y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Research 2006; 66:4011-9.
Frick C, Odermatt, A, Zen K, Mandell KJ, Edens H, Portmann R, Mazzucchelli L, Jaye DL, Parkos CA. Interaction of ICAM-1 with ¿2 integrin CD11c/CD18: Characterization of a peptide ligand that mimics a putative binding site on ICAM-1. European Journal of Immunology 2005; 35:3610-3621.
Hunter S, Weiss S, Ou C-Y, Jaye D, Young A, Wilcox J, Arbiser JL, Monson D, Goldblum J, Nolen JD, Varma V. Apolipoprotein D is down-regulated during malignant transformation of neurofibromas. Human Pathology 2005;36(9):987-93.
Lonial S, Waller EK, Richardson PG, Jagannath S, Orlowski RZ, Giver C, Jaye DL, Francis D, Lehman M, Torre C, Barlogie B, Berenson JR, Singhal S, Schenkein DP, Esseltine DW, Anderson J, Xiao H, Heffner LT, Anderson KC. Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood 2005; 106:3777-3784.
Fujita N, Jaye DL, Geigerman C, Akyildiz A, Mooney MR, Boss JM, Wade PA. MTA3 and the MI-2/NuRD complex regulate cell fate during B-lymphocyte differentiation. Cell 2004; 119: 75-86
Jaye DL, Geigerman C, Akyildiz A, Fuller RE, Parkos CA. Direct fluorochrome labeling of phage display library clones for studying binding specificities: applications in flow cytometry and fluorescence microscopy. Journal of Immunological Methods 2004; 295(1-2): 119-27.
Roback JD, Hossain MS, Lezhava L, Gorechlad JW, Alexander SA, Jaye DL, Mittelstaedt S, Talib S, Hearst JE, Hillyer CD, Waller, EK. Allogeneic T-cells treated with amotosalen prevent lethal CMV disease without producing GvHD following BMT. Journal of Immunology 2003; 171(11): 6023-6031
Giver CR, Montes RO, Mittelstaedt S, Li JM, Jaye DL, Lonial S, Boyer MW, Waller EK. Ex vivo fludarabine exposure inhibits graft-versus-host activity of allogeneic T cells while preserving graft-versus-leukemia effects. Biology of Blood and Marrow Transplantation 2003; 9(10): 616-32
Jaye DL, Nolte FS, Mazzucchelli L, Geigerman C, Akyildiz A, Parkos CA. Use of real time polymerase chain reaction to identify cell and tissue type selective peptides by phage display. American Journal of Pathology 2003; 162: 1419-1429
Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA. MTA3, a Mi-2/NURD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 2003; 113(2): 207-219
Hunter S, Young A, Olson J, Brat DJ, Bowers G, Wilcox JN, Jaye D, Mendrinos S, Neish A. Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non- infiltrating primary CNS neoplasms. J Neuropathology and Experimental Neurology 2002; 61(3): 275-281
Edens HA, Levi BP, Jaye DL, Walsh S, Reaves TA, Turner JR, Nusrat A, Parkos CA. Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration. Journal of Immunology 2002; 169(1): 476-486
Jaye DL, Edens, HA, Mazzucchelli, LM, Parkos, CA. Novel G-protein coupled responses in leukocytes elicited by a chemotactic bacteriophage displaying a cell-type selective binding peptide. Journal of Immunology 2001; 166:7250-7259
Marques MB, Jaye DL , Waites KB, Kilby JM , Reddy VB. Histologic examination of bone marrow core biopsy specimens has limited value in the diagnosis of mycobacterial and fungal infections in patients with the acquired immunodeficiency syndrome. Annals of Diagnostic Pathology 2000; 4:1-6
Miller JE, Wilson SS, Jaye DL, Kronenberg M. An Automated Semi-quantitative B and T Cell Clonality Assay. Molecular Diagnosis 1999; 4:101-117
Kilby JM, Marques MB, Jaye DL, Waites KB, Reddy VB. The Role of Bone Marrow Biopsy versus Culture in the Evaluation of HIV-infected Patients for Mycobacterial and Fungal Infections. American Journal of Medicine 1998; 104:123-128
Jaye DL, Moser SA, Parker BA, Bragg S, Waites KB. Comparative Evaluation of two Rapid Latex Agglutination Tests for Detection of Cryptococcal Capsular Polysaccharide. The American Journal of Clinical Pathology 1998; 109:634-641
Yamagata M, Jaye DL, Sanes JR. Gene Transfer to Avian Embryos with a Recombinant Adenovirus. Developmental Biology 1994; 116: 355-359
Ernst JD, Hoye E, Blackwood RA, Jaye D. Purification and Characterization of an Abundant Cytosolic Protein from Human Neutrophils that Promotes Ca++-Dependent Aggregation of Isolated Specific Granules. Journal of Clinical Investigation 1991; 85:1065-1071
Prater CA, Plotkin J, Jaye D, Frazier WA. The Properdin-like Type I Repeats of Human Thrombospondin Contain a Cell Attachment Site. Journal of Cell Biology 1991; 112:1031-1040
Lonial S, Jaye D, Waller EK. Liver disease following bone marrow transplantation. In: Hepatology. 4th Edition, D. Zakim and T. Boyer, Eds., pp. 1699-1710, 2002 Orlando, Elsevier Science
Frazier WA, Prater CA, Jaye D, Kosfeld M. Thrombospondins: Biological Functions for structural motifs. In: Thrombospondin. CRC Press, J. Lahav Ed. 1993, pp. 91-109.
Webber S, Jaye D. The Effect of Biopterin and its Reduced Derivatives on Cultured Human Lymphocytes. In: Chemistry and Biology of the Pteridines. B.A. Cooper, V.M. Whitehead Eds., 1986 pp. 235-238
Jaye DL, Parkos CA. Neutrophil Migration across Intestinal Epithelium. Annals of the New York Academy of Sciences. 2000; 915; 151-159.
Jaye DL, Waites KB. Clinical Applications of C-reactive Protein in Pediatrics. The Pediatric Infectious Disease Journal 1997; 16:735-747