Charles E Hill, MD

Molecular Pathology

Assistant Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Associate Director of Molecular Diagnostics Laboratory, Emory University Hospital

Co-Director, Molecular Genetic Pathology Fellowship, Emory University School of Medicine

Pathology Division(s):
Clinical Pathology

Email Address:
cehill@emory.edu

Education:

BS   Biochemistry, Clemson University, 1985 - 1989

MD   Medical University of South Carolina, 1989 - 1998

PhD   Molecular And Cellular Biology, Medical University of South Carolina, 1989 - 1998

Research Interests:

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I am participating in a variety of research projects centered on translating basic science research into clinical practice. We have been investigating the role of virally encoded oncogenes in aggressive behavior of laryngeal papillomatosis, the clinical utility and implementation of pharmacogenetics, and the development of tests for diagnosis or prognosis in a variety of malignanacies.

Clinical Focus:

I am engaged in development of clinical pharmacogenetic testing and molecular tumor diagnostics, as well as overseeing day-to-day operations of the molecular diagnostics laboratory. I am also involved in the clinical interpretation of protein electrophoresis and autoimmunity testing.

Honors / Awards:

Golden Apple Teaching Award, 2004-2005

Alpha Omega Alpha, 1997

Norris Medal, Best All-Around Student, Clemson University, 1989

Summa Cum Laude, Clemson Univeristy, 1989

Faculty Scholarship Award, Clemson University, 1989

Specialty Boards:

2004 Diplomate Anatomic and Clinical Pathology, American Board of Pathology

2005 Diplomate Molecular Genetic Pathology, American Board of Pathology & American Board of Medical Genetics

Selected Publications:

Published and Accepted Research Articles -

Hill, CE. Harris, SB. Culler, EE. Zimring, JC. Nolte, FS. Caliendo, AM. Performance Characteristics of Two Real-Time PCR Assays for the Quantification of Epstein-Barr Virus DNA. Am J Clin Pathol. 2006;125:665-671.

Hill, CE. Duncan, A. Wirth, D. Nolte, FS. Detection and Identification of Cytochrome P-450 2C9 Alleles *1, *2, and *3 by High-Resolution Melting Curve Analysis of PCR Amplicons. Am J Clin Pathol 2006;125:584-591

Deyrup, AT. Lee, VK. Hill, CE. Cheuk, W. Toh, HC. Kesavan, S. Chan, EW. Weiss, SW. Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006 Jan;30(1):75-82.

Hill, CE. Caliendo, AM. Viral Load Testing. In: Molecular Microbiology: Diagnostic Principles and Applications. Eds: Persing, DH. Tenover FC. Versalovic J. Tang, Y-W. Unger, ER. Relman, DA. White TJ. ASM Press, 2004.

Hill, CE. Green, AM. Ingersoll, J. Easley, K. Nolte, FS. Caliendo, AM. Assessment of Agreement between the AMPLICOR HIV-1 MONITOR Test Versions 1.0 and 1.5. Journal of Clinical Microbiology. 42(1), 2004 Jan.

Fiebelkorn KR. Lee BG. Hill CE. Caliendo AM. Nolte FS. Clinical evaluation of an automated nucleic acid isolation system. Clinical Chemistry. 48(9):1613-5, 2002 Sep.

Folpe AL. Hill CE. Parham DM. O'Shea PA. Weiss SW. Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor. American Journal of Surgical Pathology. 24(12):1657-62, 2000 Dec.

Philip AT. Amin MB. Tamboli P. Lee TJ. Hill CE. Ro JY. Intravesical adipose tissue: a quantitative study of its presence and location with implications for therapy and prognosis. American Journal of Surgical Pathology. 24(9):1286-90, 2000 Sep.

Davis A. Fields A. Hill C. Hanzlick R. Unavoidable outcomes vs misadventures. Autopsy Committee of the College of American Pathologists. Archives of Internal Medicine. 159(7):646-7, 1999 Apr 12.

Liu Y. Raghunathan K. Hill C. He Y. Bunni MA. Barredo J. Priest DG. Effects of antisense-based folypoly-gamma-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells. Biochemical Pharmacology. 55(12):2031-7, 1998 Jun 15.

Lenz HJ. Hill C. Danenberg KD. Leichman LL. Priest DG. Danenberg PV. Rapid quantitative PCR for determination of relative gene expressions in tissue specimens. PCR Methods & Applications. 4(5):305-8, 1995 Apr

Liu Y. Bhalla K. Hill C. Priest DG. Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line. Biochemical Pharmacology. 48(6):1265-72, 1994 Sep 15.

Book Chapters -

Caliendo AM and Hill CE, Human Immunodeficiency Virus Type 1. In: Molecular Diagnostics for the Clinical Laboratorian 2nd Edition. Eds. WB Coleman and GJ Tsongalis. Humana Press. pp. 453-459.

F.S. Nolte and C.E. Hill. 2006. Polymerase Chain Reaction and other Amplification Technology. In: Clinical Diagnosis and Management by Laboratory Methods, 21st ed. W.B. Saunders Co.

Hill, CE and Caliendo, AM. Viral Load Testing. In: Molecular Microbiology. Diagnostic Principles and Practice. 2004. 2nd Edition. Eds. DH Persing, FC Tenover, J Versalovic, Y-W Tang, ER Unger, DA Relman, TJ White. ASM Press. pp. 478-488.

Other Publications -

Hill, CE. Duncan, A. Nolte, FS. Determination of CYP2C9 Genotype by High Resolution Amplicon Melting Curve Analysis Using LCGreen I. Association for Molecular Pathology, Orlando, FL, 2003.

Subtil, A. Hill, CE. Nolte, FS. Mann, KP. Clinical Validation of the LightCycler t(15;17) Real-Time RT-PCR Kit for the Detection of PML-RAR¿ RNA. Association for Molecular Pathology, Orlando, FL, 2003.

Hill, CE. Green, AM. Ingersoll, J. Nolte, FS. Caliendo AM. Comparison of Versions 1.0 and 1.5 of the AMPLICOR HIV -1 MONITOR Test, Association For Molecular Pathology, Dallas, TX, 2002.

Hill CE. Folpe AL. Parham DM. O'Shea PA. Weiss SW. Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor. United States and Canadian Academy of Pathology, New Orleans, LA 2000

Hill, C. E., Lankford, K. V., Brown, W. V., Duncan, A., and Hillyer, C. D. Plasma Exchange (TPE) for Elevated Lipoprotein(a) (Lp(a)) in a Patient with Xanthoma Disseminatum (XD). American Association of Blood Banks, San Francisco, CA, 1999.

Priest, D. G., Liu, Y., Raghunathan, K., Hill, C., He, Y., Barredo, J. C., and Bunni, M. A. Effect of folylpoly-¿-gluatmate synthase down-regulation on reduced folate accumulation and cellular proliferation in a human T-lymphoblastic leukemic cell line. American Association for Cancer Research, New Orleans, LA, 1998.

Hill, C. E. and Priest, D. G. Response of thymidylate synthase message to methotrexate in a human leukemic cell line. South Carolina Statewide Research Conference, Charleston, SC, 1996.

Hill, C. E. and Priest, D. G. Elevation of thymidylate synthase in response to methotrexate and tomudex in a human leukemic cell line. American Association for Cancer Research, Washington, D. C., 1995.

Hill, C. E. and Priest, D. G. Elevation of thymidylate synthase protein in response to antifolates in a human leukemic cell line. Gordon Conference on Chemotherapy of Experimental and Clinical Cancer, New London, NH, 1995.

Liu, Y., Bhalla, K., Hill, C., and Priest, D. Evidence for involvement of tyrosine phosphorylation in taxol induced apoptosis in a human ovarian tumor cell line. American Association for Cancer Research, San Francisco, CA, 1994.