Pathology Faculty Member

James C Ritchie, PhD

Clinical Chemistry

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Associate Director, Core and Toxicology Laboratories, Emory University Hospital

Director, Core Laboratory, Emory Crawford Long Hospital

Pathology Division(s):
Clinical Pathology
Experimental Pathology

Email Address:
jritchi@emory.edu

Education:

BS Bachelor of Science, Zoology, The University of Michigan, 1970 -

Master Master of Public Health, Epidemiology,The University of Michigan, 1976 -

PhD Doctor of Philosophy, Pharmacology, Duke University, 1995 -

Research Interests:

-
My research laboratory is engaged in determing whether the regulation of extracellular peptidase activity plays a significant role in neuropeptide action. In another project, we are focusing on the pharmacokinetics/pharmacodynamics of antidepressants and anti-seizure medications during pregnancy. Finally I am actively pursuing investigations into the use of proteomics as a clinical diagnostic tool.

Honors / Awards:

Travel Fellowship, Summer Neuropeptide Meeting, 1995

Endocrine Society Summer Student Fellowship, 1989

Specialty Boards:

2001 Diplomate Diplomate, American Board of Clinical Chemistry

Selected Publications:

Published and Accepted Research Articles -

Hostetter, A.L., Stowe, Z.N., Cox, M., Ritchie, J.C. (2004). A novel system for the determination of antidepressant concentrations in human breast milk. Therapeutic Drug Monitoring 26: 47-52, Feb.

Pomara, N., Willoughby, L.M., Ritchie, J.C., Sidtis, J.J., Greenblatt, D.J., Nemeroff, C.B. (2004). Interdose elevation in plasma cortisol during chronic treatment with alprazolam but not lorazepam in the elderly. Neuropsychopharmacology. 29(3):605-11, Mar.

Stowe, Z.N., Hostetter, A.L., Owens, M.J., Ritchie, J.C., Sternberg, K., Cohen, L.S., Nemeroff, C.B. (2003). The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. Journal of Clinical Psychiatry. 64(1):73-80, Jan.

Ritchie, J.C., Davis, T.P., Nemeroff, C.B. (2003). Action of three ectopeptidases on corticotropin-releasing factor: Metabolism and functional aspects. Neuropsychopharmacology 28: 22-33, Jan.

Newport, D.J., Heim, C., Owens, M.J., Ritchie, J.C., Ramsey, C.H., Bonsall, R., Miller, A.H., Nemeroff, C.B. (2003). Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. Neuropsychopharmacology. 28(3):569-76, Mar.

Rose, J.E., Behm, F.M., Ramsey, C., Ritchie, J.C.. (2001). Platelet monoamine oxidase, smoking cessation and tobacco withdrawal symptoms. Nicotine and Tobacco Research 3: 383-390.

Stowe, Z.A., Cohen, L.S., Hostetter, A., Ritchie, J.C., Owens, M.J., Nemeroff, C.B. (2000). Paroxetine in human breast milk and nursing infants. Amer. Jour. Psychiatr. 157:2:185-189.

McCune, J.S., Hawke, R.L., LeCluyse, E.L., Gillenwater, H.H., Hamilton, G., Ritchie, J.C., Lindley, C. (2000). In-vivo and in-vitro induction of human cytochrome P4503A4 by dexamethasone. Clin Pharmacol Ther. 68:356-366.

Cassidy, F., Ritchie, J.C., Verghese, K., Carroll, B.J. (2000). Dexamethasone metabolism in dexamethasone suppression test suppressors and nonsuppressors. Biol Psychiatry. 47:677-680.

Slotkin, T.A., Seidler, F.J., Ritchie, J.C. (2000). Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: Effects of olfactory bulbectomy in young versus aged rats. Brain Research 882:149-154.

Ritchie, J.C. (1999). Homocysteine and neuropsychiatric disorders. Diagnostic Endo, Immuno, and Metab., 17:35-38.

Weber, C.J. and Ritchie, J.C. (1999). Retrospective analysis of sequential changes in serum intact parathyroid hormone (PTH) levels during conventional parathyroid exploration. Surgery 126:1139-1144.

Cassidy, F., Ritchie, J.C., Carroll, B.J. (1998). Plasma dexamethasone concentrations and cortisol response during manic episodes. Biological Psychiatry, 43:747-754.

Slotkin, T.A., Seidler, F.J., Ritchie, J.C. (1998). Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: Therapeutic Implications. Brain Research Bulletin, 47:345-348.

Radke, J.M., Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1998). Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions. Proc. Natl. Acad. Sci. (USA), 95:11462-11464.

Slotkin, T.A., McCook, E.C., Ritchie, J.C., Carroll, B.J., Seidler, F.J. (1997). Serotonin transporter expression in rat brain regions and blood platelets: Aging and glucocorticoid effects. Biological Psychiatry, 41:172.

McCall, W.V., Weiner, R.D., Carroll, B.J., Shelp, F.E., Ritchie, J.C., Austin, S., Norris, J. (1996). Serum prolactin, electrode placement, and the convulsive threshold during ECT. Convulsive Therapy, 12(2):81-85.

Slotkin, T.A., McCook, E.C., Ritchie, J.C., Seidler, F.J. (1996). Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological Psychiatry, 40:576-584.

Krishnan, K.R.R., Tupler, L.A., Ritchie, J.C., McDonald, W.M., Knight, D.L., Nemeroff, C.B., Carroll, B.J. (1996). Apoliprotein E-,4 frequency in geriatric depression. Biological Psychiatry, 40:69-71.

Cowley, D.S., Roy-Byrne, P.P., Radant, A., Ritchie, J.C., et al. (1995). Benzodiazepine sensitivity in panic disorder: Effects of chronic alprazolam treatrnent. Neuropsychopharmacology, 12:147-157.

Burke, M.A., McEvoy, J.P., Ritchie, J.C. (1994). A pilot study of a structured interview addressing sexual function in men with schizophrenia. Biological Psychiatry, 35: 32-35.

Wall, T.L., Nemeroff, C.B., Ritchie, J.C., Ehlers, C.L. (1994). Cortisol responses following placebo and alcohol in Asians with different ALDH2 genotypes. Journal of Studies on Alcohol, 55:207-213.

Krishnan, K.R.R., Ritchie, J.C., Tupler, L.A., McDonald, W.M., Knight, D., Nemeroff, C.B., Marcovina S. (1994). Apolipoprotein E-,4. [letter] Neurology, 44:2420-2421.

Blazer, D.G., Malmrose, L.C., Wallsten, S.M., Nemeroff, C.B., Reed, D., Ritchie, J.C., Tyrey, R.N. (1993). Rhythmicity and response to AM and PM CRH challenge in elderly subjects. Neurobiol. of Aging, 14:101-106.

Krishnan, K.R.R., Miller, M.N., Helms, M.J., Reed, D., Ritchie, J.C., et al. (1993). Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH 1-24. Eur. Arch. Psychiat. & Clin. Neurosci., 242:240-243.

Coffey, C.E., Wilkinson, W.E., Weiner, R.D., Ritchie, J.C., Aque, M. (1993). The dexamethasone suppression test and quantitative cerebral anatomy in depression. Biological Psychiatry, 33:442-449.

Krishnan, K.R.R., Rayasam, K., Reed, D., Smith, M., Chapell, P., Saunders, W.B., Ritchie, J.C., Carroll, B.J., Nemeroff, C.B. (1993). The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results. Depression, 1: 133-136.

Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1992). 5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Brain Research, 573:353-355.

Gupta, S.K., Ritchie, J.C., Wiedemann, K., Holsboer, F. (1992). Modeling the pharmacokinetics and pharmacodynamics of dexamethasone in depressed patients. Eur. Jour. Clin. Pharmaco1., 43:51-55.

Ritchie, J.C., Owens, M.J., Mayer, H., Watson, J.T., Kilts, C., Carroll, B.J. (1992). Preliminary studies of 6,B-Hydroxy-Dexamethasone and its importance in the DST. Biological Psychiatry, 32:825-833.

Krishnan, K.R.R., Reed, D.R., Wilson, W.H., Saunders, W., Ritchie, J.C., Nemeroff, C.B., Carroll, B.J. (1992). RU-486 in Depression. Prog. Neuropsycho-pharmacol. Biological Psychiatry, 16:913-920.

Axelson, D.A., Doraiswamy, P.M., Boyko, O.B., Escalona, P.R., McDonald, W.M., Ritchie, J.C., et al. (1992). In Vivo Assessment of pituitary volume with magnetic resonance imaging and systematic stereology: Relationship to dexamethasone suppression test results in patients. Psychiatry Research, 46:63-70.

Weiss, J.M., Sundar, S.K., Cierpial, M.A., Ritchie, J.C. (1991). Effects of IL-1 infused into brain are antagonized by Alpha-Melanocyte Stimulating Hormone (a-MSH) in a dose dependent manner. Eur. Jour. Pharmacol., 192: 177-179.

Roy-Byrne, P.P., Cowley, D.S., Hommer, D., Ritchie, J.C., Greenblatt, D., Nemeroff, C.B. (1991). Neuroendocrine effects of diazepam in panic and generalized anxiety disorders. Biological Psychiatry, 30:73-80.

Gupta, S.K., Krishnan, K.R.R., Ellinwood, E.H., Ritchie, J.C., Nemeroff, C.B. (1991). Pharmacokinetics of human growth hormone response to growth hormone releasing factor. Life Science, 47:1887-1893.

Owens, M.J., Overstreet, D.H., Knight, D.L., Rezvani, A.H., Ritchie, J.C., Bissette, B.G., Janowsky, D.S., Nemeroff, C.B. (1991). Alterations in the hypothalamic-pituitary adrenal Axis in a proposed animal model of depression with genetic muscarinic supersensitivity. Neuropsychopharmacology, 4:87-93.

Sundar, S.K., Cierpial, M.A., Ritchie, J.C., Weiss, J.M., et al. (1991). Human immunodeficiency virus glyoprotein (GP 120) infused into rat brain induces IL-l to eliminate pituitary-adrenal activity and decrease peripheral cellular immune responses. proc. Natl. Acad. Sci., USA, 88:11246-11250.

Owens, M.J., Knight, D.L., Ritchie, J.C., Nemeroff, C.B. (1991). The 5 HT2 Agonist (¿) 1 (2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor containing neuron in the rat brain. Jour. Pharmacol. Exp. Ther., 256:787-794.

Owens, M.J., Knight, D.R., Ritchie, J.C., Nemeroff, C.B. (1991). The 5 HT2 Agonist (¿) 1 (2,5-dimethyl-4-bromophenyl)-2-aminopropane (DOB) stimulates the hypothalamic pituitary-adrenal (HPA) Axis: II. Biochemical and physiological evidence for the development of tolerance after chronic administration. Jour. Pharmacol. Exp. Ther., 256:795-800.

Paris, J.M., Lorens, S.A., Lee, J.M., Mitsushio, H., Ritchie, J.C., Nemeroff, C.B. (1991). Muscimol injections into the median raphe nucleus increase serum ACTH and corticosterone concentrations via a non-serotonergic mechanism. Pharmacol. Biochem. Behav., 39:765-768.

Potts, N.L.S., Davidson, J.R.T., Krishnan, K.R.R., Doraiswamy, P.M., Ritchie, J.C. (1991). Levels of urinary free cortisol in social phobia. J. Clin. Psychiatry, 52: 41-42.

Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Saunders, W., Li, S.W., Venkataraman, S., Nemeroff, C.B., Carroll, B.J. (1991). Fast feedback regulation of ACTH by cortisol. Prog. Neuropsychopharmacol. Biological Psychiatry, 15:523-529.

Ritchie, J.C., Belkin, B.M., Krishnan, K.R.R., Nemeroff, C.B., Carroll, B.J. (1990). Plasma dexamethasone concentrations and the dexamethasone suppression test. Biological Psychiatry, 27:159-173.

Kayganich, K., Watson, J.T., Kilts, C., Ritchie, J.C. (1990). Determination of plasma dexamethasone by chemical oxidation and electron capture negative ionization mass spectrometry. Jour. of Biomedical and Environ. Mass Spectrometry, 19:341-347.

Krishnan, K.R.R., Ritchie, J.C., Sauunders, W.B., Nemeroff, C.B., Carroll, B.J. (1990). Adrenocortical sensitivity to low dose ACTH administration in depressed patients. Biological Psychiatry, 27:930-933.

Krishnan, K.R.R., Ritchie, J.C., Saunders, W., Wilson, W., Nemeroff, C.B., Carroll, B.J. (1990). Nocturnal and early morning secretion of ACTH and cortisol in humans. Biological Psychiatry, 28:47-57.

Krystal, A., Krishnan, K.R.R., Raitiere, M., Poland, R., Ritchie, J.C., Dunnick, N.R., Hanada, K., Nemeroff, C.B. (1990). The differential diagnosis and pathophysiology of Cushing's Syndrome and Primary Affective Disorder. Jour. Neuropsychiatry and Clin. Neurosciences, 2:34-43.

Sundar, S.K., Cierpial, M.A., Kilts, C., Ritchie, J.C., Weiss, J.M. (1990). Brain IL-l induced immunosuppression occurs through activation of both pituitary-adrenal axis and the sympathetic nervous system by corticotropin releasing factor. Jour. Neurosci., 10,#11:3701-3706.

Sundar, S.K., Becker, K.J., Fleener, S.L., Cierpial, M.A., Ritchie, J.C., Weiss, J.M. (1989). Intracerebral infusion of Interleukin l rapidly decreases peripheral cellular immune responses. Proc. Natl. Acad. Sci., USA, 86:6398-6402.

Li, S.W., Ritchie, J.C., Carroll, B.J. (1989). Plasma corticosterone in the dexamethasone suppression test on depressed patients. Proc. Chinese Acad. of Med. Sci. and PUMC., 4;2, 72-74.

Nemeroff, C.B., Krishnan, K.R.R., Belkin, B.M., Ritchie, J.C., Clark, C., Vale, W.W., Rivier, J.E., Thorner, M.O. (1989). The growth hormone response to GHRF in alzheimer's disease. Neuroendocrinology, 50:663-666.

Krishnan, K.R.R., Manepalli, A.N., Ritchie, J.C., et al. (1988). Growth hormone releasing factor stimulation test in depression. Peptides, 2 (Suppl 1):113-116.

Naylor, M.R., Krishnan, K.R.R., Manepalli, A.N., Ritchie, J.C., et al. (1988). Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man. J. Clin. Endocrinol. Metab., 67:404-406.

Antelman, S.M., Knopf, S., Kocan, D., Edwards, D.J., Ritchie, J.C., Nemeroff, C.B. (1988). One stressful event blocks multiple actions of diazepam for up to at least a month. Brain Research, 445:380-385.

Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Nemeroff, C.B., Carroll, B.J. (1988). Adrenocortical sensitivity to ACTH in humans. Biological Psychiatry, 24: 105-108.

Smith, M.A., Davidson, J., Ritchie, J.C., Kudler, H., Lipper, S., Chappell, P., Nememff, C.B. (1988). The corticotropin releasing hormone test in patients with posttraumatic stress disorder. Biological Psychiatry, 26:349 355.

Krishnan, K.R.R., Hayman, A., Ritchie, J.C., Utley, C.M., Dawson, D.V., Rogers, H. (1988). Depression in early-onset alzheimer's disease: Clinical and neuroendocrine correlates. Biological Psychiatry, 24:937-940.

Goldstein, D., Nishita, J.K., Ritchie, J.C., Kuhn, C.M., Ellinwood, E.H., Laszlo, J. (1988). Pituitary-adrenal responses to chemotherapy and antiemetics. The Cancer Jour., #2:25-29, Jan Feb.

Goldstein, D., Gockerman, J., Krishnan, K.R.R., Ritchie, J.C., et al. (1987). Effects of gamma interferon on the endocrine system: Results from a Phase I study. Cancer Res., 47:6397-6399.

Liu, P.K., Bissette, G., Ritchie, J.C. (1987). Optimization off the solid phase extraction of plasma CRH for subsequent RIA analysis. Neuroendo, Let., 2: 177-179.

Chappell, P.B., Smith, M.A., Kilts, C.D., Bissette, G., Ritchie, J.C., et al. (1986). Alterations in CRF like immunoreactivity in discrete rat blain regions after acute and chronic stress. J. Neurosci., 6:2908-2914.

Ritchie, J.C., Carroll, B.J., Olton, P.R., Shively, V.S., Feinberg, M. (1985). Plasma cortisol determination for the dexamethasone suppression test. Comparison of competitive protein binding and commercial radioimmunoassay methods. Arch. Gen. Psych., 42:493-497.

Wilens, T.E., Ritchie, J.C., Carroll, B.J. (1984). Comparison of plasma cortisol and corticosterone in the dexamethasone suppression test for melancholia. Psychoneuroendocrinology, 9:45-55.

Privitera, M.RR., Greden, J.F., Ritchie, J.C., et al. (1982). Interference by Carbamazepine with the Dexamethasone Suppression Test. Biological Psychiatry, 17:599-608.

Ritchie, J.C., Carroll, B.J. (1982). The dexamethasone suppression test in psychiatric diagnosis. Lab. Management, 20:41-51.

Ritchie, J.C., Carroll, B.J. (1981). Melanchollic patients: A new test to identify depression. Lab. World, 32:25-29.

Carroll, B.J., Schroeder, K., Ritchie, J.C., et al. (1980). Plasma dexamethasone concentrations and cortisol suppression response in patients with endogenous depression. J. Clin. Endocrinol. Metab., 51:433-437.

Castor, C.W., Ritchie, J.C., et al. (1979). Connective tissue activation XIV. Arthritis and Rheumatism, 22:260-272.

Castor, C.W., Ritchie, J.C., Scott, M.E., et al. (1977). Connective tissue activation Xl. Arthritis and Rheumatism, 220:859-868.

Ritchie, J.C., Smith, S.F., Castor, C.W. (1977). Measurement of urinary and serous-luid glycosaminoglycans and urinary hydroxyproline. Amer. J. Clin. Path., 67:5855-590.

Castor, C.W., Ritchie, J.C., et al. (1975). Connective tissue activation VII. J. Lab. and Clin. Med., 85:392-404.

Castor, C.W., Scott, M.E., Ritchie, J.C., et al. (1975). Connective tissue activation IX. Arthritis and Rheumatism, 18:451-560.

Castor, C.W., Ritchie, J.C., et al. (1974). Connective tissue activation VI. J. Lab. and Clin. Med., 83:45-55.

Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith S.F. (1973). Connective tissue activation V. J. Lab. and Clin. Med., 81:95-99.

Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith, S.F. (1972). Connective tissue activation III. J. Lab. and Clin. Med., 79:285-301.

Castor, C.W., Smith, S.F., Ritchie, J.C., Scott, M.D. (1972). Connective tissue activation: Mechanism and Significance. Biology of the Fibroblast, 483-499. Proceedings of the Juselius Foundation Symposium, August.

Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith, S.F. (1972). Connective tissue activation IV. Arthritis and Rheumatism, 15:504-510.

Castor, C.W., Ritchie, J.C., et al. (1971). Abnormalities of connective tissue cells cultured from rheumatoid arthritis. J. Lab. and Clin. Med., 77:665-675.

Castor, C.W., Smith, S.F., Ritchie, J.C., et al. (1971). Connective tissue activation II. Arthritis and Rheumatism, 14:55-65.

Castor, C.W., Dorstewitz, E., Smith, S.F., Ritchie, J.C. (1971). Connective tissue activation I. Arthritis and Rheumatism, 14:41-54.

Castor, C,W., Rowe, K., Dorstewitz, E., Ritchie, J.C. (1970). Regulation of collagen and hyaluronate formation in human synovial fibroblast cultures. J. Lab. and Clin. Med, 755:798-881.

Book Chapters -

Owens, M.J., and Ritchie, J.C. (1999). Clinical Neurochemistry. In: The Neurobiological Foundation of Mental Illness, (Charney, D.S., Nestler, E.J., Bunney, B.S., Eds.), Oxford University Press, New York , NY.

Ritchie, J.C., Bissette, G. (1992). Radioimmunoassay methods. In: Neuroendocrinology, (Nemeroff, C.B., Ed), CRC Press, Boca Raton, Florida, 39-50.

Ritchie, J.C., Nemeroff, C.B. (1991). The hypothalamic pituitary adrenal axis and depression. In: Stress, Neuropeptides, and Systemic Disease, (McCubbin, J.A., Kaufmann, P.G., and Nemeroff, C.B., Eds.), Academic Press, Orlando, Florida, 181-197.

Krishnan, K.R.R., Doraiswamy, P.M., Venkataraman, S., Reed, D., Ritchie, J.C. (1991). Current concepts in hypotalamo pituitary adrenal axis regulation. In: Stress, Neuropeptides, and Systemic Disease, (McCubbin, J.A., Kaufmann, P.G., and Nemeroff, C.B., Eds.), Academic Press, Orlando, Florida, 19-35.

Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Venkataranman, S., France, R.D., Nemeroff, C.B., Carroll, B.J. (1988). What is the relationship between plasma ACTH and plasma cortisol in normal humans and depresssed patients? In: The Hypothalamic-Pituitary-Adrenal Axis, (Schatzberg, A.F. and Nemeroff, C.B., Eds.), Raven Press, New York, 115-132.

Kilts, C.D., Johnson, K.L., Ritchie, J.C. (1987). Analytical and methodological considerations in the study of the HPA Axis. In: The Hypothalamic-Pituitary-Adrenal Axis, (Schatzberg, A.F. and Nemeroff, C.B., Eds.), Raven Press, New York, 37-53.

Krishnan, K.R.R., Nemeroff, C.B., Manepalli, A.N., France, R.D., Ritchie, J.C., Carroll, B.J. (1986). Physiology of Human HPA regulation in depression. In: Biological Psychiatry, (Shagass C., et al, Eds.), Elsevier, New York, 808-810.

Other Publications -

Ritchie, J.C., Whooley, M.A., Mullins, R.E. (2002) Evaluation of Two Extended Range CRP Assays. 18th International Congress of Clinical Chemistry, Kyoto, Japan.

Ritchie, J.C., Mullins, R.E.; Benson, E, Davis, T. (2001) Comparison of Five Assays for Homocysteine. American Association for Clinical Chemistry Annual Meeting, Chicago, IL.

Ritchie, J.C. and Ramsey, C. (2001) Pretreatment with High Dose CRF Increases Subsequent CRF Catabolism in Rat Pituitary Cultures. Society for Neuroscience Annual Meeting SanDiego, CA.

Ritchie, J.C., Mullins, R.E.; Benson, E, Davis, T. (2001) Comparison of Five Assays for Homocysteine. American Association for Clinical Chemistry Annual Meeting, Chicago, IL.

Ritchie, J.C. and Ramsey, C. (2001) Pretreatment with High Dose CRF Increases Subsequent CRF Catabolism in Rat Pituitary Cultures. Society for Neuroscience Annual Meeting SanDiego, CA.

Ritchie, J.C., Tuten, T., Jerkunica, I., Zhang, H., Sgoutas, D.S., Mullins, R.E. (1998). Evaluation of the Cobas-Integra for routine lipid testing. Clin Chem, 44(6): A78.

Ritchie, J.C., Mullins, R.E., Tuten, T., Zhang, H., Jerkunica, I. (1998). Evaluation of the DAU lysergic acid diethylamide (LSD) assay on the Cobas-Integra. Clin Chem, 44(6): A86.

Ritchie, J.C., Tuten, T., Jerkunica, I., Zhang, H., Sgoutas, D.S., Mullins, R.E. (1998). Evaluation of the Cobas-Integra for routine lipid testing. Clin Chem, 44(6): A78.

Ritchie, J.C., Slotkin, T.A., Seidler, F.J. (1998). Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: Therapeutic Implications. Society for Neuroscience Abstracts, 24, 28th Annual Meeting, Los Angeles, CA.

Ritchie, J.C., Mullins, R.E., Tuten, T., Zhang, H., Jerkunica, I. (1998). Evaluation of the DAU lysergic acid diethylamide (LSD) assay on the Cobas-Integra. Clin Chem, 44(6): A86.

Ritchie, J.C., Tuten, T., Jerkunica, I., Zhang, H., Mullins, R.E. (1997). Evaluation of the Cobas-Integra for drugs of abuse testing. Clin Chem, 43(6): S217.

Mullins, R.E., Jerkunica, I., Ritchie, J.C., Tuten, T. (1997). HbA1c measurements by immunoassay on the Cobas-Integra. Clin Chem, 43(6): S154.

Ritchie, J.C., Zhang, W. (1996). Modification of the BioRad antidepressant methodology to measure the serotonin reuptake inhibitors. Clin Chem, 42(6): S222, 48th Annual Meeting, Chicago, IL.

Kim, D.K., Kim, B.L., Yu, B.H., Hong, K.S., Ritchie, J.C., Austin, S., Carroll, B.J. (1995). Rate-sensitive glucocorticoid feedback inhibition in normal humans and depressed patients. Society for Neuroscience Abstracts, 21(2): 873, 25th Annual Meeting, San Diego, CA.

Ritchie, J.C., Nemeroff, C.B. (1995). Effect of three ectopeptidases on corticotropin-releasing factor: Metabolism and functional aspects. Society for Neuroscience Abstracts, 21(1): 761, 25th Annual Meeting, San Diego, CA.

Ritchie, J.C., Sundar, K.S., Nemeroff, C.B. (1994). Effect of specific peptidase inhibitors on CRF induced ACTH release in cultured rat pituitary cells. Society of Neuroscience Abstracts, 20(1), 447, 24th Annual Meeting, Miami Beach, FL.

Akers, L.C., Ritchie, J.C., Orsulak, P.J. (1993). Determination of salivary cortisol using a modification of the Abbott TDx serum cortisol assay. Clin Chem, 6:1255.

Ritchie, J.C., Nemeroff, C.B. (1993). Corticotropin releasing factor degradation by purified peptidases. Society of Neuroscience Abstracts, 19(2):1363, 23rd Annual Meeting, Washington, D.C.

Akers, L.C., Ritchie, J.C., Orsulak, P.J. (1993). Determination of salivary cortisol using a modification of the Abbott TDx serum cortisol assay. Clin Chem, 6:1255.

Ritchie, J.C., Nemeroff, C.B. (1993). Corticotropin releasing factor degradation by purified peptidases. Society of Neuroscience Abstracts, 19(2):1363, 23rd Annual Meeting, Washington, D.C.

Bragg, C., Ritchie, J.C., Carroll, B.J., Breitner, J.C.S. (1992). A matched twin study of DHEA and DHEA-S in alzheimer's disease. Biological Psychiarty, 31:201A.

Hayden-Hixson, D.M., White, N., Ritchie, J.C., Nemeroff, C.B. (1992). Neonatal handling: Effects on spatial memory, basal corticosterone levels, and hippocampal function. Society Neuroscience Abstracts, 18(2):1426, 22nd Annual Meeting, Annaheim, California.

Bragg, C., Ritchie, J.C., Carroll, B.J., Breitner, J.C.S. (1992). A matched twin study of DHEA and DHEA-S in alzheimer's disease. Biological Psychiarty, 31:201A.

Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1991). THDOC decreases plasma corticosterone concentrations via a non glucocorticoid mechanism. Society for Neuroscience Abstracts, 17(2):1343, 21st Annual Meeting, New Orleans, Louisiana.

Ritchie, J.C., Gupta, S.K., Carroll, B.J., Krishnan, K.R.R. (1991). Towards a pharmacokinetic pharmacodynamic model of plasma dexamethasone concentration during the DST. Biological Psychiatry, 29(suppl): 725S.

Ritchie, J.C., Bragg, D.C., White, N.R., Krishnan, K.R.R., Carroll, B.J. (1991). Plasma vasopressin, cortisol, and ACTH baseline levels in depression. Neuroendocrinology Letters, 13:208.

Ritchie, J.C., Owens, M.J., Nemeroff, C.B. (1991). Corticotropin releasing factor metabolism in the rat hypothalamus. Society for Neuroscience Abstracts, 17(1): 404, 21st Annual Meeting, New Orleans, Louisiana.

Ritchie, J.C., Bragg, D.C., White, N.R., Krishnan, K.R.R., Carroll, B.J. (1991). Plasma vasopressin, cortisol, and ACTH baseline levels in depression. Neuroendocrinology Letters, 13:208.

Reed, D., Ritchie, J.C., Carroll, B.C., et al. (1990). Implications of simultaneous monitoring of plasma dexamethasone levels for the DST. Neuroendocrinology Letters, 12(4):261; XXI Congress of the International Society of Psychoneuroendocrinology, Buffalo/Niagara Falls, New York.

Vargas, M.A., Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1990). Time-course of action of the triazolobenzodiazepine, alprazolam, on HPA axis function in rats. Society for Neuroscience Abstracts, 16(1):92, 20th Annual Meeting, St. Louis, Missouri.

Clerpial, M.A., Grobin, A.C., Hargrove, E.F., McLean, K.P., Ritchie, J.C., et al. (1990). Elevated dorsal noradrenergic bundle turnover and plasma corticosterone responses to stress in rats selectively bred for high swim test activity. Society for Neuroscience Abstracts, 16(1): 165, 20th Annual Meeting, St. Louis, Missouri.

Ritchie, J.C., Scotch, R.L., Walker, J.T., et al. (1989). Human growth hormone response to ovine corticotropin-releasing factor. Society for Neuroscience Abstracts, 15(2):1373, l9th Annual Meeting, Phoenix, Arizona.

Nishita, J.K., Ellinwood, E.H., Rockwell, W.J.K., Ritchie, J.C., et al. (1988). A new chronic starvation paradigm in the developing female rate: Implications for the study of anorexia nervosa. 43rd Annual Meeting Society of Biological Psychiatry, Montreal, Ouebec, Canada.

Nishita, J.K., Ellinwood, E.H., Rockwell, W.J.K., Ritchie, J.C., et al. (1988). Stress-related effects of long-term caloric restriction on plasma corticosterone and vasopressin in the female rat: A new methodological apparatus. Society for Neuroscience Abstracts 14(1):444, 18th Annual Meeting, Toronto, Ontario, Canada.

Ritchie, J.C., Liu, P.K., Bissette, G., et al. (1988). A practical radioimmunoassay for plasma corticotropin releasing factor. Society for Neuroscience Abstracts, 14(2): 1286, 18th Annual Meeting, Toronto, Ontario, Canada.

Davis, M.D., Nemeroff, C.B., Ritchie, J.C. (1988). Dynamics of concomitant CRF, AVP and ACTH secretion from perfused hypothalamic hypophyseal explants in vitro after electrical stimulation and drug infusion. Annual Meeting of the Endocrine Society.

Lee, J., Mitsushio, H., Paris, J.M., Lorens, S.A., Ritchie, J.C., et al. (1987). Differential behavioral and endocrine effects produced by intra-raphe administration of the neurokinin agonist DiMe C7, and the GABA agonist, Muscimol. Society for Neuroscience Abstracts, 13(1):613, 17th Annual Meeting, New Orleans, Louisiana.

Ritchie, J.C., Kegelmeyer, A.E., Walker, J.T., et al. (1987). Comparison of plasma cortisol determinations by the Abbott TDx and C.P.B. methodology, for use in the dexamethasone suppression test (DST). Clin. Chem., 33(6):959, American Association for Clinical Chemistry, 40th Annual Meeting, San Francisco, California, 1987.

Ritchie, J.C., Liu, P.K., Nemeroff, C.B., et al. (1987). Simultaneous determination of CRF and ACTH release from hypothalamic-pituitary blocks perfused in vitro: Responses to physiological and pharmacological manipulation. Society for Neuroscience Abstracts, 13(2):1371, 17th Annual Meeting, New Orleans, Louisiana.

Johnson, K.L., Anderson, C.M., Nishita, J.K., Ritchie, J.C., et al. (1987). The distribution and dynamics of epinephrine-containing neurons in the rat brain: Influence of adrenocortical state. Society for Neuroscience Abstracts, 13(1):478, 17th Annual Meeting, New Orleans, Louisiana.

Ellinwood, E.H., Nishita, J.K., Kuhn, C.M., Ritchie, J.C., et al. (1987). Cocaine effects on plasma vasopressin, corticosterone and prolactin in the rat: Time course following acute injection. Society for Neuroscience Abstracts, 13(1):85, 17th Annual Meeting, New Orleans, Louisiana.

Ritchie, J.C., O'Ouinn, A.N., Hodges, K.V., et al. (1987). Plasma dexamethasone concentrations in children and adolescents during the dexamethasone suppression test (DST). Society of Biological Psychiatry, 42nd Annual Meeting, Chicago, Illinois.

Shun Wei, Li, Ritchie, J.C., Carroll, B.J. (1986). Plasma corticosterone and dexamethasone suppression test normalization. Society of Biological Psychiatry, 41st Annual Meeting, Washington, D.C.

Ritchie, J.C., Manepalli, A.N., France, R.D., Nemeroff, C.B., Carroll, B.J. (1986). What is the relationship between ACTH and cortisol dissociation in depression. American Psychiatric Association Annual Meeting, Washington, D.C.

Ritchie, J.C., Owens, M.J., O'Connor, L.W., et al. (1986). Measurement of ACTH and CRF immunoreactivity in adrenal gland and lymphocytes. Society for Neuroscience Abstracts, 12(2): 1041, 16th Annual Meeting, Washington, D.C.

Belkin, B.M., Ritchie, J.C., Rayasam, K., et al. (1986). Plasma dexamethasone concentrations and the dexamethasone suppression test. Society for Neuroscience Abstracts, 12(1):606, 16th Annual Meeting, Washington, D.C.

Manepalli, A.N., Ritchie, J.C., Rayasam, K., et al. (1986). GRH stimulation test in depression. American Psychiatric Association Annual Meeting, Washington, D.C.

Chappell, P.B., Smith, M.A., Ritchie, J.C., et al. (1986). Effects of corticotropin releasing factor on plasma ACTH and cortisol concentrations in schizophrenia. Society for Neuroscience Abstracts, 12(2): 1441, 16th Annual Meeting, Washington, D.C.

Nemeroff, C.B., Krishnan, K.R.R., Owens, M.J., Bissette, G., Manepalli, A.N., Ritchie, J.C., et al. (1986). Growth hormone releasing factor: Endocrine and cerebrospinal fluid studies. Society for Neuroscience Abstracts, 12(1): 566, 16th Annual Meeting, Washington, D.C.

Manepalli, A.N., Ritchie, J.C., Rayasam, K., et al. (1986). GRH stimulation test in depression. American Psychiatric Association Annual Meeting, Washington, D.C.

Shun Wei, Li, Ritchie, J.C., Carroll, B.J. (1986). Plasma corticosterone and dexamethasone suppression test normalization. Society of Biological Psychiatry, 41st Annual Meeting, Washington, D.C.

Ritchie, J.C., Keglemeyer, A.E., Walker, J.T. (1985). Performance of two non-extracted radioimmunoassays for plasma ACTH compared with two reference laboratory assays. Society for Neuroscience Abstracts, 11(1): 545, l5th Annual Meeting, Dallas, Texas.

Krishnan, K.R.R., Carroll, B.J., Manepalli, A.N., France, R.D., Ritchie, J.C., Nemeroff, C.B. (1985). Physiology of human HPA regulation, IV World Congress of Biological Psychiatry.

Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., et al. (1985). What is the relationship between ACTH and cortisol in normal and depressed patients. American College of Neuropsychopharmacology Annual Meeting.

Krishnan, K.R.R., Carroll, B.J., Manepalli, A.N., France, R.D., Ritchie, J.C., Nemeroff, C.B. (1985). Physiology of human HPA regulation, IV World Congress of Biological Psychiatry.

Castor, C.W., Scott, M.E., Ritchie, J.C. (1971). Pharmacologic regulation of mitogenesis induced by a platelet mediator. XIV International Congress of Rheumatology.

Castor, C.W., Wright, D., Ritchie, J.C. (1969). Connective tissue regulation. J. Lab and Clin. Med. Abstract, 74:860.

More information on...

Contact Information:

For an expert Pathology consultation,
or to send a specimen, call:

James C Ritchie, PhD

Clinical Chemistry

Professor
Pathology & Laboratory Medicine

Education:

Research Interests:

Honors / Awards:

Specialty Boards:

Selected Publications:

Published and Accepted Research Articles -

Book Chapters -

Other Publications -

More information on...

Contact Information:

For an expert Pathology consultation, or to send a specimen, call:

James C Ritchie, PhD Clinical Chemistry

Professor Pathology & Laboratory Medicine

Education:

Research Interests:

Honors / Awards:

Specialty Boards:

Selected Publications:

Published and Accepted Research Articles -

Book Chapters -

Other Publications -

For an expert Pathology consultation,
or to send a specimen, call:

James C Ritchie, PhD

Clinical Chemistry

Professor
Pathology & Laboratory Medicine