Pathology Faculty Member

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    Clinical Pathology
    F143-D EUH
    Atlanta, GA 30322
    404 712-5456 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Shiyong Li, MD, PhD

    Hematopathology

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Member, Winship Cancer Institute

    Director, Anatomic Pathology FISH Laboratory, Emory University Hospital

    Attending Hematopathologist, Emory University Hospital

    Attending Molecular Pathologist, Emory University Hospital


    Pathology Division(s):
    Clinical Pathology


    Email Address:
    sli2@emory.edu


    Education:

    MD   AnHui Medical University, China, 1979 - 1984

    PhD   University of Iowa, 1989 - 1995

    Residency   University of Pennsylvania Hospital, 1995 - 1999

    Fellowship   Johns Hopkins Hospital, 1999 - 2000



    Research Interests:

    - Hematolymphoid malignancies
    Using modern technology such as flow cytometry, fluorescent in situ hybridization, laser-captured microdissection and cDNA microarray, I am especially interested in (1) investigation of the underlying molecular mechanisms of leukemo/lymphomagenesis; (2) identification of new marker(s) to aid in diagnosis and in predicting the clinical outcome of malignant hematopoietic disorders; (3) development of new diagnostic tests in the field of hematopathology.



    Clinical Focus:

    Hematopathology - morphology, flow cytometry and molecular diagnostics


    Fluorescence in situ hybridization for hematolymphoid and solid organ tissue malignancies


    Honors / Awards:

    The Emory Golden Apple Teaching Award

    , 2010-2011

    The Emory Golden Apple Teaching Award, 2003-2004

    CUSBEA Scholar, 1989-1995

    Specialty Boards:

    1999  Diplomate, Anatomic and Clinical Pathology, American Board of Pathology


    2001  Diplomate, Hematology, American Board of Pathology


    2007  Diplomate, Molecular Genetic Pathology, American Board of Pathology


    Selected Publications:

    Published and Accepted Research Articles -

    Wang HY, Huang L, Garcia R, Li S and Galliani CA (2011) Erythroblastic Sarcoma Presenting as Bilateral Ovarian Masses in an Infant with Pure Erythroid Leukemia. Human Pathology 42:749-58.


    Ahsanuddin A, Brynes RK and Li S (2011) Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: Report of 3 cases and review of the literature. Int J Clin Exp Pathol 4; 416-20.


    Cotta CV, Coleman JF, Li S and His ED (2011). Progression of nodular lymphocyte predominant Hodgkin lymphoma to diffuse large B-cell lymphoma: a study of 6 cases concurrently involving the same site. Histopathology (in press)


    Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP (2010) A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. Am J Clin Pathol 133:718-26.


    Li S and Lee AK (2010) Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction? Int J Clin Exp Pathol 3:117-127.


    Zapata M, Budnick SD, Bordoni R and Li S (2010). An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma. Int J Clin Exp Pathol 3:430-6.


    Kraus TS, Sillings CN, Saxe DF, Li S and Jaye DL (2010). The role of CD11c expression in the diagnosis of mantle cell lymphoma. Am J Clin Pathol 134:271-7.


    Wang HY*, Li S*, Woodford RL, Cousar JB and Mills SE (2010) BCL2 chromosomal translocation is not a general feature of the interdigitating dendritic cell sarcoma. Diag Mol Pathol 19:169-71 (*co-first author)


    Li S (2009). Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a distinct clinicopathological entity Int J Clin Exp Pathol 2: 508-518


    Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR and Li J-J (2009) NF-kappB-mediated HER-2 overexpression in radiation-induced adaptive tumor resistance. Radiation Res 171, 9-21.


    Zeng W, Styblo TM, Li S, Sepulveda JN and Schuster D (2009) Breast angiosarcoma: PDG PET findings. Clin Nucl Med 34: 443-445.


    Salisbury CL, Budnick SD and Li S (2009) T-cell receptor gene rearrangement and CD30 immunoreactivity in traumatic ulcerative granuloma with stromal eosinophilia of the oral cavity. Am J Clin Pathol 132: 722-727.


    Chan C-B, Hao C, Abe M, Hashimoto N, Nakao S, Liu X, Williams IR, Yepes M, Li S, Asano M, Hara-Nishimura I, Luo HR and Ye K (2009) Mice lacking asparagine endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome. Proc Natl Acad Sci USA 106, 468-473.


    Webber BA, Cushing MM and Li S (2008) Prognostic significance of flow cytometric immunophenotyping in acute myeloid leukemia. Int J Clin Exp Pathol 1:124-133.


    Li S, Mann KP and Holden JT (2008) Composite small lymphocytic lymphoma and extramedullary myeloid tumor: a potential diagnostic pitfall. Int J Clin Exp Pathol 1, 91-97.


    Jaye D, Iqbal J, Fujita N, Geigerman C, Li S, Karanam S, Fu K, Weisenburger D, Chan W, Moreno C and Wade P (2007) The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. J Pathol 213: 106-115.


    Liu J, Liu Y-G, Huang R, Yao C, Li S, Yang W, Yang D and Huang R-P (2007) Concurrent down-regulation of EGR-1 and Gelsolin in majority of human breast cancer cells. Cancer Genomics & Proteomics 4:377-386.


    Danzy S, Su C-Y, Park S, Li S, Ferraris AM and Ly H (2006) Absence of pathogenic mutations of the human telomerase RNA gene (hTERC) in patients with chronic myeloproliferative disorders. Leukemia 20: 893-894.


    Huang R, Li S, Yang W, Chen L, Yao C and Huang RP (2006) Early growth response-1 suppresses human fibrosarcoma cell invasion and angiogenesis. Cancer Genomics & Proteomics 3: 71-82.


    Li, S, K.P. Mann and J.T. Holden (2004) T-cell-rich B-cell lymphoma presenting in the spleen: a clinicopathologic analysis of three cases. Int. J. Surg. Pathol. 12: 31-7.


    Li, S. Juco J, JT Holden and KP Mann (2004) Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Am. J. Clin. Pathol. 121: 268-74.


    Lin Y, R. Huang, L. Chen, S. Li, Q. Shi, C. Jordan and R.P. Huang (2004) Identification of IL-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays. Int. J. Cancer 109: 507-15.


    Castellano-Sanchez A, S. Li, J. Qian, A. Lagoo, E. Weir and D.J. Brat (2004). Primary central nervous system posttransplant lymphoproliferative disorders. Am. J. Clin. Pathol. 121: 246-53.


    Alvorado CS, Straus SE, Li S, Dale JK, Mann K, Le A and Lauer S (2004). Autoimmune lymphoproliferative syndrome: a cause of chronic splenomegaly, lymphadenopathy and cytopenias in children. Report on diagnosis and management of five patients. Pediatric Blood and Cancer 43: 16416-16419.


    Li, S and G Lew (2003) Is B-lineage Acute Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression and L1 Morphology a Precursor B Lymphoblastic Leukemia/Lymphoma or Burkitt Leukemia/Lymphoma? Arch. Pathol. Lab. Med . 127: 1340-4.


    Lin Y, R. Huang, Y-G. Liu, H Lisoukov, C.C.Wang, S. Li and R.P. Huang (2003) Profiling of cytokines by biotin-labeled and antibody-based protein arrays. Proteomics 3; 1750-7.


    Chen X, P.E. Jensen and S. Li. (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. Am. J. Clin. Pathol. 119; 842-51.


    Juco, J., J. T. Holden, L.G. Kelly, Karen P. Mann and S. Li (2003) Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am. J. Clin. Pathol. 119: 205-12.


    Chen, C, O. Laur O, T. Kambayashi, S. Li, R.A. Bray, D.A. Weber, L. Karlsson, and P.E. Jensen (2002): Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. J. Exp. Med. 195: 1053-62.


    Li, S., J. R. Eshleman, and M.J. Borowitz (2002) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkins lymphoma. Am. J. Clin. Pathol. 118: 229-34.


    Li, S. (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.


    Li, S., K.P. Mann, J.T. Holden (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.


    Akpek, G., E.K. Akpek, S. Li, T. P. OBrien, R. Green, and M.J. Borowitz (2001) Unusual locations for lymphomas: successive occurrence of peripheral T-cell lymphoma with bilateral conjunctival involvement in a patient with low-grade B-cell lymphoma. J. Clin. Oncology 19; 2964-6


    Li, S. and M. J. Borowitz (2001) CD79a-positive T-cell lymphoblastic lymphoma with coexisting Langerhans cell histiocytosis: a short case report and review of the literature. Arch. Pathol. Lab. Med. 125; 958-60.


    Li, S., D. T. Ross, M. E. Kadin, P. O. Brown and M. A. Wasik (2001) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. Am. J. Pathol. 158; 1231-7.


    Li, S., R. J. Couzi, C. A. Griffin, A. Friedman and M. J. Borowitz (2001) A novel variant three-way translocation of inversion 16 in a case of AML-M4eo following low dose methotrexate therapy. Cancer Genet. Cytogenet. 125; 74-7.


    Li, S. and M. J. Borowitz (2001). Primary Epstein-Barr virus-associated Hodgkins disease of the ileum complicating Crohns disease. Arch. Pathol. Lab. Med. 125; 424-7.


    Li, S., C. A. Griffin, R. B. Mann and M. J. Borowitz (2001) Primary cutaneous T-cell-rich B-cell lymphoma: clinically distinct from its nodal counterpart? Modern Pathol. 14; 10-3.


    Majewski, M., M. Korecka, P. Kossev, S. Li, J. Goldman, J. Moore, L. Silberstein, W. Schuler, L. Shaw and M. A. Wasik (2000) The immunosuppressive macrolide SDZ RAD inhibits growth of EBV-transformed B lymphocytes in vitro and in vivo: a potential novel approach to prevention and treatment of post-transplant lymphoproliferative disorders (PTLDs). Proc. Natl. Acad. Sci. USA 97: 4285-90.


    Li, S. (2000) Multiple pulmonary nodules with calcification. Arch. Pathol. Lab. Med. 124: 1393-94.


    Brodsky, R.A., G.L. Mukhina, S. Li, K.L. Nelson, P.L. Chiurazzi, J.T. Buckley and M.J. Borowitz (2000). Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin. Am. J. Clin. Pathol. 114: 459-66.


    Li, S., Z. W. Baloch, J. E. Tomaszewski, and V. A. LiVolsi (2000) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. Arch. Pathol. Lab. Med. 124, 87-91.


    Li, S., R. L. Zimmerman, and V. A. LiVolsi (1999) Mixed malignant germ cell tumor of the fallopian tube. Int. J. Gynecol. Pathol. 18, 183-5.


    Li, S. and K. E Salhany (1999) Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. Arch. Pathol. Lab. Med. 123, 1111-4.


    Filali, M., S. Li, H.-W. Kim, B. Wadzinski and M. Kamoun (1999). Identification of a type 6 protein serine/threonine phosphatase regulated by interleukin-2 stimulation. J. Cell. Biochem. 73, 153-63.


    Li, S., J. M. Junkins-Hopkins, D. L. Fraker, and M. van der Rijn (1999) Desmoplastic fibroblastoma (collagenous fibroma): case report and review of the literature. Int. J. Surg. Pathol. 7, 33-8.


    Li, S., Z. W. Baloch, A. C. Boudousquie, and P. K. Gupta (1999) Aluminum silicate-containing psammoma bodies in a cervicovaginal smear (Pap): cytological, ultrastructural, and radiographic microprobe studies. Diagn. Cytopathol. 21, 122-4.


    Karpati, R. L., L. A. Loevner, D. M. Cunning, D. M. Yousem, S. Li, and R. S. Weber (1998) Synchronous schwannomas of the hypoglossal nerve and cervical sympathetic chain. Am. J. Roentgenol. 171, 1905-1907.


    Baum, E. D., A. C. Boudousquie, S. Li, and N. Mirza (1998) Sarcoidosis with nasal obstruction and septal perforation. Ear, Nose, & Throat J. 77, 896-902.


    Li, S., M. E. Wilson and J. E. Donelson (1996) Leishmania chagasi: a gene encoding a protein kinase with a catalytic domain structurally related to MAP kinase kinase. Exp. Parasitol. 82, 87-96.


    Li, S. and J. E. Donelson (1995) Inhibition of protein phosphatase 1 and 2A down-regulates b-tubulin gene expression in Trypanosoma brucei rhodesiense. Biochem. Biophys. Res. Commun. 212, 793-9


    Li, S. and J. E. Donelson (1993) The gene for the TATA box-binding protein of Oncocerca volvulus. Mol. Biochem. Parasitol. 61, 321-4.


    Book Chapters -

    Li, S. (1999). Complementary DNA microarray: the bridge between molecular biology and pathology. In: Advances in Medical Molecular Biology, Y.-F. Shen (ed.), pp137-143, Beijing and Springer-Verlag Heidelberg.


    Other Publications -

    Li S (2011) T cell prolymphocytic leukemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology


    Li S (2011) Diffuse large B-cell lymphoma - monomorphic posttransplant lymphoproliferative disorder. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology


    Li S (2010) Burkitt lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology


    Woodford RL, Wang HY, Li S, Mills SE and Cousar JB. T(14;18)-negative interdigitating dendritic cell sarcomas: a morphologic and immunohistochemical review. USCAP meeting, 2010, Washington DC.


    Li S (2010) Transformation of nodular lymphocyte-predominant Hodgkin lymphoma to diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology


    Wertheim GBW, Roullet M, Jones D, Young KH, Li S, Wu H and Choi JK. Sensitive and specific detection of gamma T-cell receptor in paraffin-embedded T-cell lymphomas. USCAP meeting, 2010, Washington DC.


    Li S (2009) Cutaneous mastocytoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology


    Kossover C, Budnick S and Li S. Clonal T-cell receptor gene rearrangements in traumatic ulcerative granuloma with stromal eosinophilia. USCAP meeting, 2009, Boston.


    Li S (2009) Peripheralization of malignant lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology


    Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP. A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. USCAP meeting, 2009, Boston


    Roullet M, Gheith S, Mauger J, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cells in panniculitis by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA


    Li S (2008) Primary central nervous system diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology


    Roullet M, Gheith S, Cornfield D, Mauger J, Wu H, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cell lymphoma by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA


    Cao N, Li S, Wang Z, Degnan M, Fan M, Ahmed KM and Li J-J (2008) NF-kappB-mediated HER-2 overexpression in acquired tumor radioresistance. AACR meeting, Phoenix, Arizona


    Kossover CL, Budnick SD and Li S (2008) Traumatic ulcerative granuloma with stromal eosinophilia: reactive ulcer or lymphoproliferative disorder? USCAP meeting, Denver, CO


    Li S (2008) Systemic lupus lymphadenitis. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology


    Zapata M, Choi W and Li S (2007) CD5-positive B cell lymphoma with coexpression of FMC7 and CD23: mantle cell lymphoma or small lymphocytic lymphoma? Clinical Cytometry Society meeting, Washington DC


    Amanuel B, Deyrup AT, Hill CE, Foulks C, Blasingame A, Li S and Weiss SW (2007) Molecular testing of for synovial sarcoma. Australian Division of IAP meeting, Autralia


    Li S (2007) Diamond-Blackfan anemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology


    Li S (2007) Classical Hodgkin lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology


    Li S (2006) Heinz body-induced hemolysis. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology


    Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of acute myeloid leukemia (AML) at diagnosis and relapse. USCAP meeting, Vancouver, BC, Canada


    Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of precursor B-cell acute lymphoblastic leukemia(B-ALL): Correlation with short-term treatment outcomes. USCAP meeting, Vancouver, BC, Canada


    Zornosa X and Budnick S and Li S (2003) Lymphoma of the head and neck: a retrospective study. Am Acad Oral Maxillofacial Pathol Meeting, Banff, Canada


    Li S, Chen X and Jensen PE (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. USCAP meeting, Washington DC


    Li S (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.


    Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L and Jensen PE (2001) Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. ASHI meeting, San Francisco, CA


    Li S, Mann KP and Holden JT (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.


    Li, S, Eshleman JR and Borowitz MJ (2001) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkin's lymphoma. USCAP meeting, Atlanta, GA


    Li S, Ross DT, Kadin ME, Brown PO and Wasik MA (2000) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. USCAP meeting, New Orleans, LA


    Li S, Baloch ZW, Tomaszewski JE and LiVolsi VA (1999) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. IAP meeting, France