Shiyong Li, MD, PhD

Hematopathology

Associate Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Attending Hematopathologist, Emory University Hospital

Attending Molecular Pathologist, Emory University Hospital

Director, Anatomic Pathology FISH Laboratory, Emory University Hospital

Director, Hematopathology Fellowship Program, Emory University Hospital

Pathology Division(s):
Clinical Pathology

Email Address:
sli2@emory.edu

Education:

MD   AnHui Medical University, China, 1979 - 1984

PhD   University of Iowa, 1989 - 1995

Residency   University of Pennsylvania Hospital, 1995 - 1999

Fellowship   Johns Hopkins Hospital, 1999 - 2000

Research Interests:

- Hematolymphoid malignancies
Using modern technology such as flow cytometry, fluorescent in situ hybridization, laser-captured microdissection and cDNA microarray, I am especially interested in (1) investigation of the underlying molecular mechanisms of leukemo/lymphomagenesis; (2) identification of new marker(s) to aid in diagnosis and in predicting the clinical outcome of malignant hematopoietic disorders; (3) development of new diagnostic tests in the field of hematopathology.

Clinical Focus:

Hematopathology - morphology, flow cytometry and molecular diagnostics

Fluorescence in situ hybridization for hematolymphoid and solid organ tissue malignancies

Honors / Awards:

The Emory Golden Apple Teaching Award, 2003-2004

CUSBEA Scholar, 1989-1995

Specialty Boards:

1999  Diplomate, Anatomic and Clinical Pathology, American Board of Pathology

2001  Diplomate, Hematology, American Board of Pathology

2007  Diplomate, Molecular Genetic Pathology, American Board of Pathology

Selected Publications:

Published and Accepted Research Articles -

Webber BA, Cushing MM and Li S (2008) Prognostic significance of flow cytometric immunophenotyping in acute myeloid leukemia. Int J Clin Exp Pathol 1:124-133.

Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR and Li J-J (2008) NF-kappB-mediated HER-2 overexpression in radiation-induced adaptive tumor resistance. Radiation Res (in press)

Li S, Mann KP and Holden JT (2008) Composite small lymphocytic lymphoma and extramedullary myeloid tumor: a potential diagnostic pitfall. Int J Clin Exp Pathol 1, 91-97.

Jaye D, Iqbal J, Fujita N, Geigerman C, Li S, Karanam S, Fu K, Weisenburger D, Chan W, Moreno C and Wade P (2007) The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. J Pathol 213: 106-115.

Liu J, Liu Y-G, Huang R, Yao C, Li S, Yang W, Yang D and Huang R-P (2007) Concurrent down-regulation of EGR-1 and Gelsolin in majority of human breast cancer cells. Cancer Genomics & Proteomics 4:377-386.

Huang R, Li S, Yang W, Chen L, Yao C and Huang RP (2006) Early growth response-1 suppresses human fibrosarcoma cell invasion and angiogenesis. Cancer Genomics & Proteomics 3: 71-82.

Danzy S, Su C-Y, Park S, Li S, Ferraris AM and Ly H (2006) Absence of pathogenic mutations of the human telomerase RNA gene (hTERC) in patients with chronic myeloproliferative disorders. Leukemia 20: 893-894.

Lin Y, R. Huang, L. Chen, S. Li, Q. Shi, C. Jordan and R.P. Huang (2004) Identification of IL-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays. Int. J. Cancer 109: 507-15.

Castellano-Sanchez A, S. Li, J. Qian, A. Lagoo, E. Weir and D.J. Brat (2004). Primary central nervous system posttransplant lymphoproliferative disorders. Am. J. Clin. Pathol. 121: 246-53.

Li, S, K.P. Mann and J.T. Holden (2004) T-cell-rich B-cell lymphoma presenting in the spleen: a clinicopathologic analysis of three cases. Int. J. Surg. Pathol. 12: 31-7.

Li, S. Juco J, JT Holden and KP Mann (2004) Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Am. J. Clin. Pathol. 121: 268-74.

Alvorado CS, Straus SE, Li S, Dale JK, Mann K, Le A and Lauer S (2004). Autoimmune lymphoproliferative syndrome: a cause of chronic splenomegaly, lymphadenopathy and cytopenias in children. Report on diagnosis and management of five patients. Pediatric Blood and Cancer 43: 16416-16419.

Li, S and G Lew (2003) Is B-lineage Acute Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression and L1 Morphology a Precursor B Lymphoblastic Leukemia/Lymphoma or Burkitt Leukemia/Lymphoma? Arch. Pathol. Lab. Med . 127: 1340-4.

Juco, J., J. T. Holden, L.G. Kelly, Karen P. Mann and S. Li (2003) Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am. J. Clin. Pathol. 119: 205-12.

Chen X, P.E. Jensen and S. Li. (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. Am. J. Clin. Pathol. 119; 842-51.

Lin Y, R. Huang, Y-G. Liu, H Lisoukov, C.C.Wang, S. Li and R.P. Huang (2003) Profiling of cytokines by biotin-labeled and antibody-based protein arrays. Proteomics 3; 1750-7.

Li, S., J. R. Eshleman, and M.J. Borowitz (2002) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkins lymphoma. Am. J. Clin. Pathol. 118: 229-34.

Li, S. (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.

Chen, C, O. Laur O, T. Kambayashi, S. Li, R.A. Bray, D.A. Weber, L. Karlsson, and P.E. Jensen (2002): Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. J. Exp. Med. 195: 1053-62.

Li, S. and M. J. Borowitz (2001) CD79a-positive T-cell lymphoblastic lymphoma with coexisting Langerhans cell histiocytosis: a short case report and review of the literature. Arch. Pathol. Lab. Med. 125; 958-60.

Akpek, G., E.K. Akpek, S. Li, T. P. OBrien, R. Green, and M.J. Borowitz (2001) Unusual locations for lymphomas: successive occurrence of peripheral T-cell lymphoma with bilateral conjunctival involvement in a patient with low-grade B-cell lymphoma. J. Clin. Oncology 19; 2964-6

Li, S., R. J. Couzi, C. A. Griffin, A. Friedman and M. J. Borowitz (2001) A novel variant three-way translocation of inversion 16 in a case of AML-M4eo following low dose methotrexate therapy. Cancer Genet. Cytogenet. 125; 74-7.

Li, S., C. A. Griffin, R. B. Mann and M. J. Borowitz (2001) Primary cutaneous T-cell-rich B-cell lymphoma: clinically distinct from its nodal counterpart? Modern Pathol. 14; 10-3.

Li, S. and M. J. Borowitz (2001). Primary Epstein-Barr virus-associated Hodgkins disease of the ileum complicating Crohns disease. Arch. Pathol. Lab. Med. 125; 424-7.

Li, S., D. T. Ross, M. E. Kadin, P. O. Brown and M. A. Wasik (2001) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. Am. J. Pathol. 158; 1231-7.

Li, S., K.P. Mann, J.T. Holden (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.

Li, S. (2000) Multiple pulmonary nodules with calcification. Arch. Pathol. Lab. Med. 124: 1393-94.

Brodsky, R.A., G.L. Mukhina, S. Li, K.L. Nelson, P.L. Chiurazzi, J.T. Buckley and M.J. Borowitz (2000). Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin. Am. J. Clin. Pathol. 114: 459-66.

Majewski, M., M. Korecka, P. Kossev, S. Li, J. Goldman, J. Moore, L. Silberstein, W. Schuler, L. Shaw and M. A. Wasik (2000) The immunosuppressive macrolide SDZ RAD inhibits growth of EBV-transformed B lymphocytes in vitro and in vivo: a potential novel approach to prevention and treatment of post-transplant lymphoproliferative disorders (PTLDs). Proc. Natl. Acad. Sci. USA 97: 4285-90.

Li, S., Z. W. Baloch, J. E. Tomaszewski, and V. A. LiVolsi (2000) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. Arch. Pathol. Lab. Med. 124, 87-91.

Li, S. and K. E Salhany (1999) Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. Arch. Pathol. Lab. Med. 123, 1111-4.

Li, S., Z. W. Baloch, A. C. Boudousquie, and P. K. Gupta (1999) Aluminum silicate-containing psammoma bodies in a cervicovaginal smear (Pap): cytological, ultrastructural, and radiographic microprobe studies. Diagn. Cytopathol. 21, 122-4.

Filali, M., S. Li, H.-W. Kim, B. Wadzinski and M. Kamoun (1999). Identification of a type 6 protein serine/threonine phosphatase regulated by interleukin-2 stimulation. J. Cell. Biochem. 73, 153-63.

Li, S., R. L. Zimmerman, and V. A. LiVolsi (1999) Mixed malignant germ cell tumor of the fallopian tube. Int. J. Gynecol. Pathol. 18, 183-5.

Li, S., J. M. Junkins-Hopkins, D. L. Fraker, and M. van der Rijn (1999) Desmoplastic fibroblastoma (collagenous fibroma): case report and review of the literature. Int. J. Surg. Pathol. 7, 33-8.

Baum, E. D., A. C. Boudousquie, S. Li, and N. Mirza (1998) Sarcoidosis with nasal obstruction and septal perforation. Ear, Nose, & Throat J. 77, 896-902.

Karpati, R. L., L. A. Loevner, D. M. Cunning, D. M. Yousem, S. Li, and R. S. Weber (1998) Synchronous schwannomas of the hypoglossal nerve and cervical sympathetic chain. Am. J. Roentgenol. 171, 1905-1907.

Li, S., M. E. Wilson and J. E. Donelson (1996) Leishmania chagasi: a gene encoding a protein kinase with a catalytic domain structurally related to MAP kinase kinase. Exp. Parasitol. 82, 87-96.

Li, S. and J. E. Donelson (1995) Inhibition of protein phosphatase 1 and 2A down-regulates b-tubulin gene expression in Trypanosoma brucei rhodesiense. Biochem. Biophys. Res. Commun. 212, 793-9

Li, S. and J. E. Donelson (1993) The gene for the TATA box-binding protein of Oncocerca volvulus. Mol. Biochem. Parasitol. 61, 321-4.

Book Chapters -

Li, S. (1999). Complementary DNA microarray: the bridge between molecular biology and pathology. In: Advances in Medical Molecular Biology, Y.-F. Shen (ed.), pp137-143, Beijing and Springer-Verlag Heidelberg.

Other Publications -

Kossover CL, Budnick SD and Li S (2008) Traumatic ulcerative granuloma with stromal eosinophilia: reactive ulcer or lymphoproliferative disorder? USCAP meeting, Denver, CO

Cao N, Li S, Wang Z, Degnan M, Fan M, Ahmed KM and Li J-J (2008) NF-kappB-mediated HER-2 overexpression in acquired tumor radioresistance. AACR meeting, Phoenix, Arizona

Roullet M, Gheith S, Mauger J, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cells in panniculitis by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA

Li S (2008) Systemic lupus lymphadenitis. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology

Li S (2008) Primary central nervous system diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology

Roullet M, Gheith S, Cornfield D, Mauger J, Wu H, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cell lymphoma by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA

Li S (2007) Diamond-Blackfan anemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology

Li S (2007) Classical Hodgkin lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology

Zapata M, Choi W and Li S (2007) CD5-positive B cell lymphoma with coexpression of FMC7 and CD23: mantle cell lymphoma or small lymphocytic lymphoma? Clinical Cytometry Society meeting, Washington DC

Amanuel B, Deyrup AT, Hill CE, Foulks C, Blasingame A, Li S and Weiss SW (2007) Molecular testing of for synovial sarcoma. Australian Division of IAP meeting, Autralia

Li S (2006) Heinz body-induced hemolysis. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology

Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of precursor B-cell acute lymphoblastic leukemia(B-ALL): Correlation with short-term treatment outcomes. USCAP meeting, Vancouver, BC, Canada

Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of acute myeloid leukemia (AML) at diagnosis and relapse. USCAP meeting, Vancouver, BC, Canada

Zornosa X and Budnick S and Li S (2003) Lymphoma of the head and neck: a retrospective study. Am Acad Oral Maxillofacial Pathol Meeting, Banff, Canada

Li S, Chen X and Jensen PE (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. USCAP meeting, Washington DC

Li S (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.

Li S, Mann KP and Holden JT (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.

Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L and Jensen PE (2001) Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. ASHI meeting, San Francisco, CA

Li, S, Eshleman JR and Borowitz MJ (2001) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkin's lymphoma. USCAP meeting, Atlanta, GA

Li S, Ross DT, Kadin ME, Brown PO and Wasik MA (2000) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. USCAP meeting, New Orleans, LA

Li S, Baloch ZW, Tomaszewski JE and LiVolsi VA (1999) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. IAP meeting, France