Lennart E Logdberg, MD, PhD

Transfusion Medicine

Associate Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Medical Director, Emory Crawford Long Hospital (ECLH)

Pathology Division(s):
Clinical Pathology
Experimental Pathology

Email Address:
llogdbe@emory.edu

Education:

M.K. (Basic Medical Degree),   Lund University, Lund, Sweden, 1973 - 1974

M.D.   Lund University, Lund, Sweden, 1973 - 1982

Ph.D   Physiological Chemistry, Lund University, Lund, Sweden. Thesis title: "Evolutionary and Immunological Aspects on beta-2-Microglobulin", 1975 - 1982

Resident   Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, 1995 - 1999

Fellow   New York Blood Center, New York, NY, 1999 - 2001

Research Interests:

- Lipocalins: Probing the Mechanisms of Allergy
This project aims to identify molecular properties of allergens responsible for their intrinsic allergenicity by focusing on the set of structurally and functionally homologous proteins of the lipocalin family that comprise the major mammalian respiratory allergens. We hypothesized that conserved molecular motifs in these lipocalins, via non-IgE interactions with the innate immune system, promote IgE-dependent allergy. In support, we recently demonstrated the presence of inducible lipocalin receptors on mast cells. This suggests roles for direct mast cell-lipocalin interactions (a) in the development and maintenance of the hypersensitive phenotype of allergy patients (xenogeneic lipocalins) and (b) in normal mast cell physiology (endogenous lipocalins), to be delineated by our ongoing investigations.

- Development of a Murine Model of Transfusion-Related Acute Lung Injury (TRALI)
TRALI, an increasingly recognized, potentially severe complication of transfusion, is characterized by respiratory distress and non-cardiogenic pulmonary edema. A diagnosis of exclusion, it is now listed as the leading cause among FDA-reported transfusion-related fatalities. TRALI is linked to presence of alloantibodies to leukocytes, but also depends on other blood component and recipient factors. In the relative absence of experimental animal studies, the pathophysiology of TRALI remains poorly characterized. To address this we aim to develop a robust murine TRALI model, based on transfused alloantibodies.

- Stem Cells and Pancreatic Islet Regeneration
We observed reversal of Streptozotocin (STZ)-induced diabetes mellitus after bone-marrow transplantation (BMT) in chimeric mice. The chimeric murine model was originally developed to study possible in situ repopulation of pancreatic islets by donor-BM-derived beta cells, but we found such islet cells to emerge only at low levels. Instead, the beta-cells of regenerated islets in STZ-mice that return to euglycemia after BMT are of recipient origin. We hypothesize that the exogenous BM-cells directly contribute to endothelial pancreas regeneration, in turn, promoting regeneration of endocrine pancreas from endogenous precursors.

Clinical Focus:

My clinical interests are in Clinical Pathology, particularly Transfusion Medicine/Blood Banking. I direct the transfusion services at Crawford Long Hospital.

Honors / Awards:

National Blood Foundation Scholar, 2005

Docent (Titular Associate Professor) in Anatomy and Cell Biology Department of Anatomy, University of Lund, Sweden, 1985

Fogarty Fellowship, National Institutes of Health, 1983 - 1984

Graduate Training Grant, University of Lund, Sweden, 1979-1982

Specialty Boards:

2001  Board certified in Clinical Pathology

2002  Board certified in Blood Banking/Transfusion Medicine,

Selected Publications:

Published and Accepted Research Articles -

L¿gdberg, L.E., Vikulina, T., Zimring, J.C. & Hillyer, C.D. Animal models of transfusion-related acute lung injury (TRALI). Transfusion Med. Rev. 23(1):13-24, 2009

Inada, M., Benten, D., Cheng, K., Joseph, B., Berishvili, E., Badve, S., L¿gdberg, L., Dabeva, M. & Gupta, S. Stage-specific regulation of adhesion molecule expression segregates epithelial stem/progenitor cells in fetal and adult human livers. Hepatol Int 2:50-62, 2008

Sheppard, C.A., L¿gdberg, L. E., Zimring, J.C. & Hillyer, C.D. Transfusion-related acute lung injury. Hematol. Oncol. Clin. North Am. (2007) 21(1):163-76.

L¿gdberg, L. Reid, M.E., Lamont, R.E. & Zelinski, T. Human blood group genes: Chromosomal locations and cloning strategies. Transfusion Med. Rev. (2005) 19(1):45-57.

Lake, P., DeLeo, J., Cerasoli, F., L¿gdberg, L., Wetall, M., & Handley, D. Pharmacodynamic evaluation of the neutralization of endotoxin by PMX622 in mice. Antimicrobial. Agents and Chemother. 48(8):2987-2992, 2004.

Badve, S., L¿gdberg, L., Lal, A., de Davila, M.T.G., Greco, M.A., Mitsudo, S., & Saxena, R. Small cells in hepatoblatoma lack "oval" cell phenotype. Mod. Pathol. 16 (9):930-936, 2003.

L¿gdberg, L., Sgan, S.L., Larsen, C.P. & Hillyer, C.D. Islet transplantation, stem cells, and transfusion medicine. (2003) Transfusion Med. Rev. 17:95-109

Badve, S., Deshpande, C., Hua, Z. & L¿gdberg, L. Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus, J. Histochem. Cytochem. 50(4):473-482, 2002.

L¿gdberg L, Reid ME, Miller JL. Cloning and genetic characterization of blood group carrier molecules and antigens. Transfusion Med. Rev. (2002) 16:1-10.

Larsson, J., Wing¿rdh, K., Bergg¿rd, T., Davies, J.R., L¿gdberg, L., Strand, S.-E. & ¿kerstr¿m, B. Distribution of 125I-labelled a1-microglobulin in rats after intravenous injection. J. Clin. Lab. Med. 137:165-175, 2001.

L¿gdberg, L., Brown, T., Uehlinger, J. & Cash K. Failure of education to alter albumin utilization. BBANYS 34:1-4, 2000.

L¿gdberg, L.E., ¿kerstr¿m, B. & Badve, S. Tissue distribution of the lipocalin alpha-1-microglobulin in the developing human fetus. J. Histochem. Cytochem. 48(11): 1545-1552, 2000

Badve, S., L¿gdberg, L., Sokhi, R., Sigal, S.H., Botros, N., Chae, S., Das, K.M. & Gupta, S. An antigen reacting with Das-1 monoclonal antibody is ontogenetically regulated in diverse organs including liver and indicates sharing of developmental mechanisms among cell lineages. Pathobiology 68:76-86, 2000.

¿kerstr¿m, B., L¿gdberg, L., Bergg¿rd, T., Osmark, P. & Lindqvist, A. Alpha-1-microglobulin - a yellow-brown lipocalin. Biochem. Biophys. Acta (2000) 1482:172-184.

L¿gdberg, L. & Wester, L. Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses. Biochem. Biophys. Acta (2000) 1482:284-297.

MacKay R.J., Clark C.K., L¿gdberg, L. & Lake, P. Effect of a polymyxin B-dextran 70 conjugate in horses with experimentally induced endotoxemia.. Am. J. Vet. Res. 60, 68,1999

Bergg¿rd, T., Enghild, J.J., Badve, S., Salafia, C.M., L¿gdberg, L. & ¿kerstr¿m, B. Histological distribution and biochemical properties of a1-microglobulin in human placenta. Am. J. Reprod. Immunol.. 41, 52, 1999.

Camerota, A.J., L¿gdberg, L., Lake, P., Larkin, V.A. & Fink, M.P. Delayed therapy with a polymyxin B-dextran conjugate (PMX-622) improves survival in rabbits with Gram-negative peritonitis. Journal of Endotoxin Research 4, 285, 1997.

Bucklin, S.E., Lake, P., L¿gdberg, L. & Morrison, D.C. Therapeutic efficacy of a polymyxin B-dextran 70 conjugate in an experimental model of endotoxemia. Antimicrobial Agents and Chemotherapy 39 (7), 1462, 1995.

L¿gdberg, L., Kaplan, E., Drelich, M., Harfeldt, E., Gunn, H., Ehrlich, P., Dottavio, D., Lake, P. & ¿stberg, L. Primate antibodies to components of the human immune system. J. Med. Primatol. 23, 285, 1994.

Nilson, B.H.K., L¿gdberg, L., Kastern, W., Bj¿rck, L. & ¿kerstr¿m, B. Purification of antibodies using Protein L-binding framework structures in the light chain variable domain. J. Immunol. Methods 164, 33, 1993.

Babiker-Mohamed, H., Forsberg, M., Olsson, M.L., Winqvist, O., Nilson, B. H. K., L¿gdberg, L., & ¿kerstr¿m, B. Monoclonal a1-microglobulin antibodies: Binding strength, binding sites, and inhibition of a1-microglobulin-induced lymphocyte stimulation. Scand. J. Immunol. 34, 655, 1991.

Babiker-Mohamed, H., ¿kerstr¿m, B. & L¿gdberg, L. The mitogenic effect of alpha-1-microglobulin on mouse lymphocytes. Evidence of T- and B- cell co-operation, and a low affinity receptor on mononuclear cells. Scand. J. Immunol. 32, 37, 1990.

¿kerstr¿m, B. & L¿gdberg, L. Alpha-1-microglobulin: An intriguing member of the lipocalin protein family. Trends in Biochem. Sci. 15, 240, 1990.

Babiker-Mohamed, H., Olsson, M.L., Boketoft, ¿., L¿gdberg, L. & ¿kerstr¿m, B. alpha-1-microglobulin is mitogenic to human peripheral blood lymphocytes. Regulation by both enhancing and suppressive serum factors. Immunobiology 180, 221, 1990.

Ar'Rajab, A., Ahr¿n, B. Alumets, J., L¿gdberg, L. & Bengmark, S. Islet transplantation to the renal subcapsular space improves late complications in streptozocin-diabetic rats. Eur. Surg. Res. 22, 270, 1990.

Sundelin, J., Bj¿rck, L. & L¿gdberg, L. The complete amino acid sequence of rat beta-2-microglobulin. Scand. J. Immunol. 27, 195, 1988.

Nilson, B.H.K., ¿kerstr¿m, B. & L¿gdberg, L. Cross-reactive monoclonal anti-alpha-1-microglobulin antibodies produced by multispecies immunization and by using Protein G for the screening assay. J. Immunol. Methods 99, 39, 1987.

¿kerstr¿m, B., L¿gdberg, L., Babiker-Mohamed, H., Lohmander, S. & Rask, L. Structural relationship between alpha-1-microglobulins from four mammalian species. Eur. J. Biochem. 170, 143, 1987.

Persson, M.-H., Schal¿n, C., Bergg¿rd, B., L¿gdberg, L., & Bj¿rck, L. Binding of aggregated beta-2-microglobulin, IgG-Fab, or kappa and lambda light chains to Group A streptococci. Acta Path. Microbiol. Scand. 94, 25, 1986.

L¿gdberg, L., ¿kerstr¿m, B. & Shevach, E.M. Alpha-1-microglobulin is mitogenic for guinea pig lymphocytes. Scand. J. Immunol. 24, 575, 1986.

Wassmer, P., Chan, C., L¿gdberg, L., & Shevach, E.M. Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells. J. Immunol. 135, 2237, 1985.

L¿gdberg, L., Wassmer, P. & Shevach, E.M. Role of the L3T4-antigen in T cell activation. I. Description of a monoclonal IgM antibody to a distinct epitope (L3T4b) of the L3T4 antigen and its effect on interleukin-1 induced thymocyte proliferation. Cell. Immunol. 94, 299, 1985.

L¿gdberg, L., & Shevach, E.M. Role of the Ly1 antigen in interleukin-1 induced thymocyte activation. Eur. J. Immunol. 15, 1007, 1985.

L¿gdberg, L., Gunter, K.C. & Shevach, E.M. Rapid production of monoclonal antibodies to T lymphocyte functional antigens. J. Immunol. Methods 79, 239, 1985.

L¿gdberg, L., & Bj¿rck, L. On the heterologous interaction between beta-2-microglobulin and the heavy chain of rat MHC class I antigens. Scand. J. Immunol. 20, 61, 1984.

¿kerstr¿m, B. & L¿gdberg, L. Alpha-1-microglobulin-glycopeptides inhibit antigen-specific stimulation of human peripheral blood leukocytes. Scand. J. Immunol. 20, 559, 1984.

Wennerberg, J., Alm, P., L¿gdberg, L., & Trop¿, C. Beta-2-microglobulin in squamous cell carcinomas of the head and neck tumours heterotransplanted into nude athymic mice. Acta-Oto-laryngologica 98, 335, 1984.

Shalev, A., Caspi, R.R., L¿gdberg, L., Bj¿rck L., Segal, S. & Avtalion, R.R. Specific activity of carp antisera against beta-2-microglobulin (beta-2-m) and evidence for a beta-2-m homologue in the carp (Cyprinus carpio). Dev. Comp. Immunol. 8, 639, 1984.

Shalev, A., Pla, M., Ginsburger-Vogel, T., Echalier, G., L¿gdberg, L., Bj¿rck, L., Colombani, J. & Segal, S. Evidence for beta-2-microglobulin-like and H-2-like antigenic determinants in Drosophila. J. Immunol. 130, 297, 1983.

L¿gdberg, L. & Bj¿rck, L. Binding of mammalian beta-2-microglobulin by glycoproteins in fish serum. Molec. Immunol. 20, 885, 1983.

K¿ll¿n, & L¿gdberg, L. Experimental autoimmune encephalomyelitis in hybrids between Lewis and Brown-Norway rats. Immunobiology 162, 86, 1982.

K¿ll¿n, B. & L¿gdberg, L. Low susceptibility to induction of experimental autoimmune encephalomyelitis in a substrain of the otherwise susceptible Lewis rat. Eur. J. Immunol. 12, 596, 1982.

L¿gdberg, L., & ¿kerstr¿m, B. Immunosuppressive properties of alpha-1-microglobulin. Scand. J. Immunol. 13, 383, 1981.

Shalev, A., Greenberg, A.H., L¿gdberg, L., & Bj¿rck, L. Beta-2-microglobulin-like molecules detected in low vertebrates and invertebrates. J. Immunol. 127, 1186, 1981.

L¿gdberg, L., Cig¿n, R. & Bj¿rck, L. Binding of beta-2-microglobulin by heterologous sera. Scand. J. Immunol. 13, 237, 1981.

Trop¿, C., L¿gdberg, L., & Johnsson, J.-E. Beta-2-microglobulin - a tumor marker of gynecological cancer. Am. J. Obstet. Gynecol. 137, 743, 1980.

L¿gdberg, L., Bj¿rck, L. & Cig¿n, R. Heterologous interaction between beta-2-microglobulin and AgB-antigens. Transplantation 30, 233, 1980.

Bergg¿rd, B., Bj¿rck, L., Cig¿n, R. & L¿gdberg, L. Beta-2-microglobulin. Scand. J. Clin. Lab. Invest. 40:Suppl. 154, 13, 1980.

L¿gdberg, L., Cig¿n, R. & Bergg¿rd, I. Effect of anti-guinea pig beta-2 microglobulin antibodies on lymphocyte transformation induced by specific antigens or mitogens. Scand. J. Immunol. 9, 263, 1979.

L¿gdberg, L., ¿stergren, P.-O. & Bergg¿rd, I. Rat beta-2-microglobulin. Isolation, properties, and relation to beta-2-microglobulins from other species. Molec. Immunol. 16, 577, 1979.

Yamashita, U., L¿gdberg, L., Bergg¿rd, I. & Shevach, E.M. The activation of guinea pig T lymphocytes by anti-beta-2-microglobulin serum. J. Immunol. 122, 1427, 1979.

Book Chapters -

Su, L. L. & L¿gdberg, L. Cryoprecipitate. In Blood banking and transfusion medicine, 2nd Ed (2007), Hillyer, C D et al. (Eds,), Churchhill Livingston, Elsevier, pp. 270-277.

Culler, E. E, & L¿gdberg, L. Albumin. In Blood banking and transfusion medicine, 2nd Ed (2007), Hillyer, C D et al. (Eds,), Churchhill Livingston, Elsevier, pp. 278-287.

Culler, E. E, & L¿gdberg, L. IVIG and related derivatives. In Blood banking and transfusion medicine, 2nd Ed (2007), Hillyer, C D et al. (Eds,), Churchhill Livingston, Elsevier, pp. 288-307.

L¿gdberg, L & ¿kerstr¿m, B. Lipocalins in clinical medicine. In Lipocalins (2006) ¿kerstr¿m, B., Borregaard, N., Flower, D.R. & Salier, J.-P. (eds.), Landes Bioscience, TX, USA.

¿kerstr¿m, B. & L¿gdberg, L. Alpha(1)-Microglobulin. In Lipocalins (2006) ¿kerstr¿m, B., Borregaard, N., Flower, D.R. & Salier, J.-P. (eds.), Landes Bioscience, TX, USA, pp.110-120

L¿gdberg, L. Leukoreduced products. Prevention of leukocyte-related transfusion-associated adverse effects. In Handbook of Pediatric Transfusion Medicine. (2004) Hillyer, C., Strauss, R.G. & Luban, N.L.C. (Eds.), Elsevier.

L¿gdberg, L. Beta-2-Microglobulin. In Encyclopedia of Molecular Medicine, pp. 346-49, John Wiley & Sons, Inc., NY, 2002.

Hendrikx, P.J., L¿gdberg, L., Debnath, G., Alespeiti, G., Dobrila, N.L., Rubinstein, P. & Visser, J.W.M. Antigen expression on placental cord blood SP cells. Leukocyte Typing VII, Oxford University Press, 2002, pp. 624-626.

L¿gdberg, L., Hendrikx, P.J., Debnath, G., Alespeiti, G., Dobrila, N.L., Dias, S., Rafii, S., Rubinstein, P. & Visser, J.M.W. Characterization of two distinct, low side-scatter, CD34-positive cell populations in human cord blood. Leukocyte Typing VII, Oxford University Press, 2002, pp. 624-626.

Weitz-Schmidt, G., Zerwes, H.-G., Dottavio, D. & L¿gdberg, L. Identification and characterization of mAb to human E- and P-selectin. In Leukocyte Typing V. Oxford University Press, London, 1995, p. 1839-1840.

L¿gdberg, L., West, S., Vattay, A. & Dottavio, D. Soluble recombinant integrin b1-chain (CD29) as a probe to identify CD29-reactive mAb. In Leukocyte Typing V. Oxford University Press, London, 1995 p. 1626-1628.

L¿gdberg, L. Beta-2-Microglobulin. In Haeberli, A. (Ed.): Human Protein Data, 3d Ed., VCH Verlagsges. mbH, Weinheim, 1995.

L¿gdberg, L. Natural antibodies - confounding factors in the production of monoclonal antibodies. Progress in Biotechnology 5, 95, 1988.

Shalev, A., L¿gdberg, L. & Bj¿rck, L. Beta-2-microglobulin, histocompatibility and H-Y antigen homologous in invertebrates and early vertebrates. In Greenberg, A.H. (Ed.); Cinader, B.A. (Series Editor): Cell receptors and cell communication in invertebrates, Karger, Basel. 1987.

L¿gdberg, L., Bj¿rck, L. & Cig¿n, R. Evolutionary conservation of the interaction between beta-2-microglobulin and beta-2-microglobulin-binding molecules. Binding of beta-2-microglobulin by heterologous cells. In Peeters, H. (Ed.) Prot. Biol. Fluids. 29, 191, 1981.

Books Edited and Written -

L¿gdberg, L. Evolutionary and immunological studies on beta-2-microglobulin. Thesis, Lund, 1982.

Other Publications -

L¿gdberg, L., Lindstr¿m, M. & Hesslow, G. Is there a correlation between left-handedness and immune disease? Swed. Med. J. 83:2717, 1986. (In Swedish)