Pathology Faculty Member

More information on...

  • Home
  • Training
  • Research
  • Clinical Services
  • Expert Consultation
  • Faculty
  • Contact Information:

    Pathology and Laboratory Medicine
    Rm H184 Emory University Hospital
    Atlanta, GA 30322
    404 727-8657 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Tristram G. Parslow, MD, PhD

    Microbial Pathogenesis
    HIV Pathogenesis

    William Patterson Timmie Professor and Chair
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Chief of Pathology Section, The Emory Clinic

    Attending Pathologist, Emory Healthcare, Emory University Hospital, and Crawford Long Hospital

    Member, Board of Directors, The Emory Clinic

    Member, Board of Directors, Emory Medical Care Foundation

    National Council Member, Association of Pathology Chairs


    Pathology Division(s):
    Experimental Pathology


    Email Address:
    tparslo@emory.edu


    Education:

    BA (Biology)   Grinnell College, - 1977

    MD Medicine; PhD Biochem   University of Iowa College of Medicine, - 1983

    Residency   Anatomic Pathology, University of California, San Francisco, - 1985

    Postdoctoral Research   Laboratory of Dr. Keith R. Yamamoto, Dept. of Biochemistry and Biophysics, University of California, San Francisco, - 1985



    Research Interests:

    - Molecular Virology of HIV and Influenza
    Our laboratory's research is focused mainly on the structure and assembly of the human immunodeficiency virus (HIV) and influenza A virus, with the goal of developing new approaches to antiviral therapy. We are particularly interested in understanding how each of these viruses is able to recognize and package its genomic RNA into new viral particles as they form within an infected cell. By combining three-dimensional structural analysis with targeted mutagenesis of virally encoded macromolecules, we are elucidating specific RNA-RNA and RNA-protein interactions that are critical for replication, and that may offer new targets for antiviral drugs.

    My other scientific interests extend broadly over the fields of immunology, virology, and the molecular basis of human disease. Past projects have included studies of human telomerase RNA; of the apoptotic regulatory proteins Bcl2 and Bax; and of immune responses to multicellular parasites; as well as co-discovery of a novel form of human severe combined immunodeficiency (SCID) that results from an inherited defect in ZAP-70, a tyrosine kinase involved in T-cell receptor signaling. In addition, as a pathologist, I have enjoyed several opportunities to collaborate in characterizing novel transgenic or knockout mouse strains whose phenotypes shed light on important facets of mammalian development, immunity, and carcinogenesis.



    Selected Publications:

    Published and Accepted Research Articles -

    Liang Y, Huang T, Ly H, Parslow TG, Liang Y; 2008, Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments; J Virol 82:229-236


    Mujeeb A, Ulyanov NB, Georgantis S, Smirnov I, Chung J, Parslow TG, James TL; 2007, Nucleocapsid protein-mediated maturation of dimer initiation complex of full-length SL1 stemloop of HIV-1: sequence effects and mechanism of RNA refolding; Nucleic Acids Res 35:2026-2034


    Gipson CL, Xin ZT, Danzy SC, Parslow TG, Ly H; 2007, Functional characterization of yeast telomerase RNA dimerization; J Biol Chem 282:18857-18863


    Ulyanov NB, Mujeeb A, Du Z, Tonelli M, Parslow TG, and James TL; 2006, NMR Structure of the Full-Length Linear Dimer of Stem-Loop 1 RNA in the HIV-1 Dimer Initiation Site; J Biol Chem 281: 16168-16177


    Regan JC, Liang Y, and Parslow TG; 2006, Defective Assembly of Influenza A Virus Due to a Mutation in the Polymerase Subunit PA; J Virol 80: 252-261


    Khan MA, Kao S, Miyagi E, Takeuchi H, Goila-Gaur R, Opi S, Gipson CL, Parslow TG, Ly H, and Strebel K; 2005, Viral RNA is Required for the Association of APOBEC3G with HIV-1 Nucleoprotein Complexes; J Virol 79: 5870-5874


    Liang Y, Hong Y, and Parslow TG; 2005, Cis-Acting Packaging Sequences in the Influenza Virus PB1, PB2, and PA Genomic RNA Segments; J Virol 79: 10348-10355


    Ly H, Calado RT, Allard P, Baerlocher GM, Lansdorp PM, Young NS, and Parslow TG; 2004, Functional Characterization of Telomerase RNA Variants Found in Patients with Hematological Disorders; Blood 105: 2332-2339


    Lin J, Ly H, Hussain A, Abraham M, Pearl S, Tzfati Y, Parslow TG, and Blackburn EH; 2004, A Universal Telomerase RNA Core Structure Includes Structure Motifs Required for Binding the Telomerase Reverse Transcriptase Protein; Proc Natl Acad Sci USA 101: 14713-14718


    Ly H, Xu L, Rivera M, Parslow TG and Blackburn E; 2003, A Role for a Novel "Trans-Pseudoknot" RNA-RNA Interaction in the Functional Dimerization of Human Telomerase; Genes and Devel 17:1078-1083


    Ly H, Blackburn EH, and Parslow TG; 2003, Comprehensive Mutational Analysis of the Core Domain of Human Telomerase RNA; Molec Cell Biol 23: 6849-6856


    Bancroft CT and Parslow TG; 2002, Evidence for Segment-Nonspecific Packaging of the Influenza A Genome; J Virol 76:7133-7139


    Ly H and Parslow TG; 2002, A Bipartite Signal for Genomic RNA Dimerization in Moloney Murine Leukemia Virus; J Virol 76:3135-3144


    Clever J, Miranda A, and Parslow TG; 2002, RNA Structure and Packaging Signals in the 5' Leader Region of the Human Immunodeficiency Virus Type-1 Genome; J Virol 76:12381-12387


    Majeti R, Xu Z, Parslow TG, Olson JL, Daikh D, Killeen N and Weiss A; 2000, An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity; Cell 103:1059-1070


    Clever JL, Taplitz R, Lockrie M, Polisky B, and Parslow TG; 2000, A Heterologous, High-Affinity RNA Ligand for Human Immunodeficiency Virus Gag Protein has RNA Packaging Activity in Vivo; J Virol 74:541-546


    Mujeeb A, Parslow TG, Zarrinpar A, Das C, and James TL; 1999, NMR Structure of the Mature Dimer Initiation Complex of HIV-1 Genomic RNA; FEBS Lett 458:387-392


    Clever JL, Eckstein D and Parslow TG; 1999, Genetic Dissociation of the Encapsidation and Reverse Transcription Functions in the 5' R Region of Human Immunodeficiency Virus Type 1; J Virol 73:101-109


    Lochrie MA, Waugh S, Pratt DG, Clever J, Parslow TG, and Polisky B; 1997, In Vitro Selection of RNAs that Bind to the Human Immunodeficiency Virus Type-1 Gag Polyprotein; Nucleic Acids Res 25:2902-2910


    Clever JL and Parslow TG; 1997, Mutant Human Immunodeficiency Virus Type-1 Genomes with Defects in Genomic RNA Packaging or Dimerization; J Virol 71:3407-3414


    Lee L, Hunter JJ, Mujeeb A, Turck C, and Parslow TG; 1996, Evidence for alpha-Helical Conformation of an Essential N-Terminal Region in the Human Bcl2 Protein; J Biol Chem 271:23284-23288


    Clever JL, Wong ML, and Parslow TG; 1996, Requirements for Kissing-Loop-Mediated Dimerization of Human Immunodeficiency Virus RNA; J Virol 70:5902-5908


    Hunter JJ, Bond B, and Parslow TG; 1996, Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis; Molec Cell Biol 16:877-883


    Hunter JJ and Parslow TG; 1996, A Peptide Sequence from Bax that Converts Bcl2 into an Activator of Apoptosis; J Biol Chem 271:8521-8524


    Clever J, Sassetti C, and Parslow TG; 1995, RNA Secondary Structure and Binding Sites for Gag Gene Products in the 5' Packaging Signal of Human Immunodeficiency Virus Type 1; J Virol 69:2101-2109


    Van Genderen C, Okamura RM, Farifias I, Quo R-G, Parslow TG, Bruhn L, Grosschedl R; 1994, Development of Several Organs that Require Epithelial- Mesenchymal Tissue Interactions is Impaired in LEF-1 Deficient Mice; Genes Devel 8:2691-2703


    Elder ME, Dong L, Clever J, Chan AC, Hope TJ, Weiss A, and Parslow TG; 1994, Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T-Cell Tyrosine Kinase; Science 264:1596-1599


    Chan AC, Kadlacek TA, Elder ME, Filipovich AH, Gray JW, Iwashima M, Parslow TG, and Weiss A; 1994, ZAP-70 Protein Tyrosine Kinase Deficiency in an Autosomal Recessive Form of Severe Combined Immunodeficiency; Science 264:1599-1601


    Mancuso VA, Hope TJ, Zhu L, Derse D, Phillips T, and Parslow TG; 1994, Post-Transcriptional Effector Domains from Rev Proteins of Feline Immunodeficiency Virus and Equine Infectious Anemia Virus; J Virol 68:1998-2001


    Hope TJ, Klein NP, Elder ME and Parslow TG; 1992, Trans-dominant Inhibition of Human Immunodeficiency Virus Type 1 Rev Occurs Through Formation of Inactive Protein Complexes; J Virol 66:1849-1855


    McDonald D, Hope TJ, and Parslow TG; 1992, Posttranscriptional Regulation by the Human Immunodeficiency Virus Type 1 Rev and Human T-Cell Leukemia Virus Type I Rex Proteins Through a Heterologous RNA Binding Site; J Virol 66:7232-7238


    Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D and McKerrow JH; 1992, Tumor Necrosis Factor alpha Restores Granulomas and Induces Parasite Egg-Laying in Schistosome-Infected SCID Mice; Nature 356:604-607


    Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin T-P, Muller WJ, Lee FS, Leder P and Varmus HE; 1992, Transgenes Expressing the Wnt-1 and int-2 Proto-oncogenes Cooperate During Mammary Carcinogenesis in Doubly Transgenic Mice; Mol Cell Biol 12:147-154


    Hope TJ, Bond BL, McDonald D, Klein NP, and Parslow TG; 1991, Effector Domains of HIV-1 Rev and HTLV-I Rex are Functionally Interchangeable and Share an Essential Peptide Motif; J Virol 65:6001-6007


    Holaday BJ, Sadick MD, Wang Z-E, Reiner SL, Heinzel FP, Parslow TG and Locksley RM; 1991, Reconstitution of Leishmania Immunity in scid Mice Using Th1- and Th2-Like Cell Lines; J Immunol 147:1653-1658


    Huang X, Hope TJ, Bond BL, McDonald D, Grahl K and Parslow TG; 1991, Minimal Rev Response Element for Human Immunodeficiency Virus Type 1; J Virol 65:2131-2134


    Sarvetnick N, Shizuru J, Liggitt D, Martin L, McIntyre B, Gregory A, Parslow T and Stuart T; 1990, Loss of Pancreatic Islet Tolerance Induced by Beta Cell Expression of IFN-Gamma; Nature 346:844-847


    Hope TJ, McDonald D, Huang X, Low J and Parslow TG; 1990, Mutational Analysis of the Human Immunodeficiency Virus Type 1 Rev Transactivator: Essential Residues Near the Amino Terminus; J Virol 64:5360-5366


    Hope TJ, Huang X, McDonald D and Parslow TG; 1990, Steroid-Receptor Fusion of the Human Immunodeficiency Virus Type 1 Rev Transactivator: Mapping Cryptic Functions of the Arginine-Rich Motif; Proc Natl Acad Sci USA 87:7787-7791


    LeBoit PE, Abel EA, Cleary ML, Hoppe RT, Williams ML, Wood GS and Parslow TG; 1988, Clonal Rearrangement of the T-Cell Receptor B Gene in the Circulating Lymphocytes of Erythrodermic Follicular Mucinosis; Blood 71:1329-1333


    Tsukamoto AS, Grosschedl R, Guzman RC, Parslow TG and Varmus HE; 1988, Expression of the int-1 Gene in Transgenic Mice is associated With Mammary Gland Hyperplasia and Adenocarcinomas in Male and Female Mice; Cell 55:619-625


    LeBoit P, Beckstead JH, Bond B, Epstein WL, Frieden I and Parslow TG; 1987, Granulomatous Slack Skin: Clonal Rearrangement of the T-Cell Receptor b Gene is Evidence for the Lymphoproliferative Nature of a Cutaneous Elastolytic Disorder; J Invest Dermatol 89:183-186


    Parslow TG, Jones SD, Bond B and Yamamoto KR; 1987, The Immunoglobulin Octanucleotide: Independent Activity and Selective Interaction with Enhancers; Science 235:1498-1501


    Parslow TG, Blair DL, Murphy WJ and Granner DK; 1984, Structure of the 5' Ends of Immunoglobulin Genes: A Novel Conserved Sequence; Proc Natl Acad Sci USA 81:2650-2654


    Parslow TG and Granner DK; 1983, Structure of a Nuclease-Sensitive Region Inside the Immunoglobulin Kappa Gene: Evidence for a Role in Gene Regulation; Nucl Acids Res 11:4775-4792


    Parslow TG, Milburn GL, Lynch RG and Granner DK; 1983, Suppressor T-Cell Action Inhibits the Expression of an Excluded Immunoglobulin Gene; Science 220:1389-1391


    Parslow TG and Granner DK; 1982, Chromatin Changes Accompany Immunoglobulin Kappa Gene Activation: A Potential Control Region Within the Gene; Nature 299:449-451


    Book Chapters -

    Parslow TG and Elder ME; 1995; Pathobiology of Immunodeficiency Disorders. In: Cellular and Molecular Pathogenesis, edited by Sirica A. New York:Raven Press


    Parslow TG and Hope TJ; 1994; Structure and Expression of the HIV-1 Genome. In: The AIDS Knowledge Base (Second edition), edited by P.T. Cohen, et al. Little, Brown and Co.


    Parslow TG; 1993; Post-Transcriptional Regulation of Human Retroviral Gene Expression. In: Molecular Biology of Human Retroviruses, edited by Cullen BR. Oxford:IRL/Oxford Press


    LeBoit P and Parslow TG; 1987; Gene Rearrangements in Lymphoma: Applications to Dermatopathology; Am J Dermatopathol 9:212-218


    Books Edited and Written -

    Parslow TG, Stites DP, Terr AI, and Imboden JB (eds.); 2001; Medical Immunology (Tenth edition). Los Altos, CA:Lange Medical Publishers.


    Stites DP, Terr AI, and Parslow TG (eds.); 1997; Lange Series - Medical Immunology (Ninth edition). Los Altos, CA:Lange Medical Publishers


    Stites DP, Terr AI, and Parslow TG (eds.); 1994; Lange Series - Basic and Clinical Immunology (Eighth edition). Los Altos, CA:Lange Medical Publishers