[Lambeth Lab Papers)


1. Estabrook, R.W., Mason, J.I., Baron, J., Lambeth, D. and Waterman, M. (1972) "Drugs, Alcohol and Sex Hormones: A Molecular Perspective of the Receptivity of Cytochrome P-450" Ann. N.Y. Acad. Sci. 212, 27-49.

2. Lambeth, J.D., and Kamin, H. (1976) "Adrenodoxin Reductase: Complex Formation with NADP(H)." In Flavins and Flavoproteins, V, (T.P. Singer, Ed.), Elsevier, Amsterdam, 647-654.

3. Lambeth, J.D., and Kamin, H. (1976) "Adrenodoxin Reductase: Properties of the Complexes of Reduced Enzyme with NADP+ and NADPH." J. Biol. Chem. 251, 4299-4306.

4. Lambeth, J.D., McCaslin, D.R. and Kamin, H. (1976) "Adrenodoxin Reductase-Adrenodoxin Complex: Catalytic and Thermodynamic Properties." J. Biol. Chem. 251, 7545-7550.

5. Lambeth, J.D. and Kamin, H. (1977) "Adrenodoxin Reductase and Adrenodoxin: The Mechanisms of Reduction of Ferricyanide and Cytochrome c." J. Biol. Chem. 252, 2908-2917.

6. Lambeth, J.D. and Kamin, H. (1978) "Flavin-Iron Sulfur Interactions in Adrenodoxin Reductase and Adrenodoxin." In Flavins and Flavoproteins, VI, (T. Yamano and K. Yagi, Eds.), Japan Scientific Societies Press, Tokyo, 641-650.

7. Kamin, H. and Lambeth, J.D. (1978) "The Role of Flavins in Electron Transfer Between Two-Electron Donors and One-Electron Acceptors." In Flavins and Flavoproteins, VI, (T. Yamano and K. Yagi, Eds.), Japan Scientific Societies Press, Tokyo, 341-348.

8. Hall, C.L. and Lambeth, J.D. (1978) "Studies of Electron Transfer from Fatty Acyl CoA Dehydrogenase and ETF." In Flavins and Flavoproteins, VI, (T. Yamano and K. Yagi, Eds.), Japan Scientific Societies Press, Tokyo, 657-668.

9. Hall, C.L., Lambeth, J.D. and Kamin, H. (1979) "Acyl CoA Complexes of General Acyl CoA Dehydrogenase and Electron-Transfer Flavoprotein." J. Biol. Chem. 254, 2023-2031.

10. Seybert, D., Lambeth, J.D. and Kamin, H. (1978) "Participation of a Second Adrenodoxin in Adrenal Cortex Mitochondrial Steriod Hydroxylations." J. Biol. Chem. 253, 8355-8385.

11. Lambeth, J.D. and Kamin, H. (1979) "Adrenodoxin Reductase-Adrenodoxin Complex: Rate-Limiting Step in NADPH-Cytochrome c Reduction." J. Biol. Chem. 254, 2766-2774.

12. Lambeth, J.D., Seybert, D. and Kamin, H. (1979) "Ionic Effects on Adrenal Steroidogenic Electron Transport: The Role of Adrenodoxin as an Electron Shuttle." J. Biol. Chem. 254, 7255-7264.

13. Lambeth, J.D., Seybert, D. and Kamin, H. (1980) "Adrenodoxin Reductase-Adrenodoxin Complex: Rapid Formation and Breakdown of the Complex and a Slow Conformational Change in the Flavoprotein." J. Biol. Chem. 255, 4667-4672.

14. Seybert, D., Lancaster, J., Lambeth, J.D. and Kamin, H. (1979) "Participation of the Membrane in the Side Chain Cleavage of Cholesterol: Reconstitution of Cytochrome P-450scc Into Phospholipid Vesicles." J. Biol. Chem. 254, 12088-12098.

15. Lambeth, J.D., Seybert, D.W. and Kamin, H. (1980) "Phospholipid Vesicle-Reconstituted Cytochrome P-450scc: Mutually-Faciliated Binding of Cholesterol and Adrenodoxin." J. Biol. Chem. 255, 138-143.

16. Lambeth, J.D., Seybert, D.W., Lancaster, J.R. and Kamin, H. (1979) "Binding of Cholesterol and Adrenodoxin to Phospholipid Vesicle-reconstituted Cytochrome P-450scc" in Microsomes, Drug Oxidations, and Chemical Carcinogenesis, (Coon, M.J., et. al., Eds) Academic Press, New York, 553-558.

17. Hall, C.L. and Lambeth, J.D. (1980) "Electron Transferring Flavoprotein: Role of the Anionic Flavosemiquinone." J. Biol. Chem. 255, 3591-3595.

18. Lambeth, J.D., Kamin, H. and Seybert, D.W. (1980) "Phospholipid Vesicle Reconstituted Cytochrome P-450scc: Role of the Membrane in Control of Activity and Spin State of the Cytochrome." J. Biol. Chem. 255, 8282-8288.

19. Lambeth, J.D., Lancaster, J.D. and Kamin, H. (1981) "Steroidogenic Electron Transport by Adrenodoxin Reductase and Adrenodoxin: Use of the Acetylated Cytochrome c as a Mechanistic Probe of Electron Transfer." J. Biol. Chem. 256, 3674-3678.

20. Merrill, A., Edmondson, D.E., Lambeth, J.D. and McCormick, D.B. (1981) "Formation and Mode of Action of Flavoproteins." Ann. Rev. Nutrition 1, 281-317.

21. DuBois, R., Simpson, E.R., Tuckey, J., Lambeth, J.D., and Waterman, M.R. (1981) "Induction of Cytochrome P-450scc by ACTH in Cultured Adult Bovine Adrenal Cells: Evidence for a Higher Molecular Weight Precursor Form of This Enzyme." Proc. Nat. Acad. Sci. 78, 1028-1032.

22. DuBois, R., John, M.E., Simpson, E.R., Waterman, M.R. and Lambeth, J.D. (1981) "The Use of Cultured Adrenal Cortical Cells in the Study of Regulation by ACTH of Mitochondrial Enzymes Involved in the Cholesterol Side Chain Cleavage." In Biochemistry, Biophysics and Regulation of Cytochrome P-450, (Gustafsson, J.A., et. al., Eds) Elsevier, Amsterdam, 515-518.

23. Lambeth, J.D. (1981) "Cytochrome P-450scc: Cardiolipin as an Effector of Activity of a Mitochondrial Cytochrome P-450." J. Biol. Chem. 256, 4757-4762.

24. Lambeth, J.D. (1981) "Flavin-to-Iron Sulfur Electron Transfer: Stopped Flow Studies of D20 Effects on NADPH-Cytochrome c Reduction by the Adrenodoxin Reductase-Adrenodoxin Complex." In Flavins and Flavoproteins, VII, (Massey, V. and Williams, C.H., Jr., Eds), Elsevier, New York, 689-694.

25. Kamin, H. and Lambeth, J.D. (1981) "Role of Flavins and Iron Sulfur Proteins in the Reduction of Cytochrome P-450." In Flavins and Flavoprotins, VII, (Massey, V. and Williams, C.H., Jr., Eds), Elsevier, New York, 655-666.

26. Lambeth, J.D., Tuckey, R. and Kamin, H. (1981) "Adrenal Mitochondrial Cytochrome P-450scc: On the Role of Membrane Phospholipids in Cholesterol Side Chain Cleavage: In Microsomes and Drug Oxidations, Fifth International Symposium, (Sato, R. and Kato, R., Eds), Wiley-Interscience, New York, 249-256.

27. Lambeth, J.D., Kitchen, S.E., Farooqui, A., Tuckey, R. and Kamin, H. (1982) "Cytochrome P-450-Substrate Interactions: Binding and Catalytic Activity Using Hydroxycholesterols." J. Biol. Chem. 257, 1876-1884.

28. Lambeth, J.D., Seybert, D.W., Lancaster, J.R., Salerno, J. and Kamin, H. (1982) "Steroidogenic Electron Transport in Adrenal Cortex Mitochondria." Mol. Cell. Biochem. 45, 13-31.

29. Kramer, R.E., DuBois, R.N., Simpson, E.R., Anderson, C.M., Kashiwagi, K., Lambeth, J.D., Jefcoate, C.R. and Waterman, M.R. (1982) "Cell-Free Synthesis of Precursor Forms of Mitochondrial Steroid Hydroxylase Enzymes of the Bovine Adrenal Cortex" Arch. Biochem. Biophys. 215, 478-485.

30. Lambeth, J.D. (1983) "22-Ketocholesterol: A Potent Competitive Inhibitor of Cytochrome P-450scc-Dependent Side-Chain Cleavage of Cholesterol" Mol. Pharm. 23, 743-747.

31. Pember, S.O., Powell, G.L. and Lambeth, J.D. (1983) "Cytochrome P-450scc-Phospholipid Interactions: Demonstration of a Cardiolipin Binding Site and Thermodynamics of Enzyme Interactions with Cardiolipin, Cholesterol, and Adrenodoxin." J. Biol. Chem. 258, 3198-3206.

32. Lambeth, J.D. and Pember, S.O. (1983) "Cytochrome P-450scc-Adrenodoxin Complex: Reducton Properties of the Substrate-Associated Cytochrome and Relation of the Reduction States of Heme and Iron Sulfur Centers to Association of the Proteins." J. Biol. Chem. 258, 5596-5602.

33. Stevens, V.I., Aw. T.Y., Jones, D.P. and Lambeth, J.D. (1983) "Oxygen-Dependence of Adrenal Cortex Cholesterol Side Chain Cleavage: Implicatons in the Rate-Limiting Steps in Steroidogenesis." J. Biol. Chem. 259, 1174-1179.

34. Vahouny, G.V., Chanderbhan, R., Noland, B.J., Irwin, D., Dennis, P., Lambeth, J.D. and Scallen, T. (1983) "Sterol Carrier Protein 2: Identification of Adrenal SCP2 and Site of Action for Mitochondrial Cholesterol Utilization." J. Biol. Chem. 258, 11731-11737.

35. Pember, S.O., Heyl, B.H., Kinkade, J.M. and Lambeth, J.D. (1984) "Cytochrome b558 from (Bovine) Granulocytes: Partial Purification from Triton X-114 Extracts, and Properties of the Isolated Cytochrome," J. Biol. Chem. 259, 10590-10595.

36. Lambeth, J.D., Geren, L.M. and Millett, F. (1984) "Adrenodoxin Interaction with Adrenodoxin Reductase and Cytochrome P-450ssc: Cross-Linking of Protein Complexes and Effects of Adrenodoxin Modification by EDC," J. Biol. Chem. 258, 10025-10029.

37. Lambeth, J.D. (1984) "Biochemistry and Molecular Biology of Cancer" in Urologic Oncology (S. Graham, Ed), Raven Press, New York, pp. 49-57.

38. Lambeth, J.D. (1984) "On the Role of Phospholipids and Membranes in the Regulation of Oxidative Enzymes" in Phospholipids and Cellular Regulation, II, (J.F. Kuo, Ed) CRC Press, New York, 189-228.

39. Nisimoto, Y. and Lambeth, J.D., (1985) "Cross-Linking of Phospholipid Vesicle-Associated NADPH-cytochrome P-450 Reductase and Cytochrome b5 by a Water-Soluble Carbodiimide," Archives Biochem. Biophys. 241, 386-396.

40. Stevens, V.L. and Lambeth, J.D. (1985) "ACTH Regulation of Mitochondrial Compartment Volumes in Rat Adrenal Cortex: On the Mechanism of Hormonal Control of Steroidogenesis." Archives Biochem. Biophys. 242, 324-327.

41. Lambeth, J.D. (1985) "Cholesterol Side Chain Cleavage in Adrenal Cortex: Comparison of the Purified, Phospholipid Vesicle Reconstituted System with Isolated Rat Mitochondria." In Lipoproteins and Cholesterol Metabolism in Steroidogenic Tissues, (J.F., Strauss and K.M. Menon, Eds) George F. Stickley Co., Philadelphia, 237-241.

42. Lambeth, J.D. and Stevens, V.L. (1985) "Cytochrome P-450scc: Enzymology, and the Regulation of Intramitochondrial Cholesterol Delivery to the Enzyme," Endocrine Research 10, 283-309.

43. Lambeth, J.D. and Kriengsiri, S. (1985) "Cytochrome P-450scc-Adrenodoxin Interactions: Ionic Effects on Binding and Regulation of Cytochrome Reduction by Bound Steroid Substrates." J. Biol. Chem. 260, 8810-8816.

44. Nisimoto, Y., Wilson, E., Heyl, B.H. and Lambeth, J.D. (1985) "NADH Dehydrogenase from Bovine Neutrophil Membranes: Purification and Properties" J. Biol. Chem. 261, 285-290.

45. Heyl, B.H., Tyrrell, D.J., and Lambeth, J.D. (1985) "Cytochrome P-450scc-Substrate Interactions: Role of the 3ß- and Side Chain Hydroxyls in Binding to Oxidized and Reduced Forms of the Enzyme" J. Biol. Chem. 261, 2743-2749.

46. Stevens, V.L., Lambeth, J.D., and Merrill, A.H. (1986) "Use of Cytochrome P-450scc to Measure Cholesterol-Lipid Interactions", Biochemistry 25, 4287-4292.

47. Wilson, E., Olcott, M.C., Bell, R.M., Merrill, A.H., and Lambeth, J.D. (1986) "Inhibition of the Oxidative Burst in Human Neutrophils by Long-Chain Bases: Role of Protein Kinase C in Activation of the Burst" J. Biol. Chem. 261, 12616-12623.

48. Tribble, D.L., Glover, M.R., and Lambeth, J.D. (1987) "Pregnenolone Production by Adrenal Mitochondria: A New HPLC Analytical Method for Cholesterol Side Chain Cleavage" J. Chromatog. 414, 411-416.

49. Kamin, H., Batie, C., Lambeth, J.D., Lancaster, J., Graham, L. and Salerno, J.C. (1985) "Paramagnetic Probes of Multicomponent Electron Transfer Systems" Biochemical Society Trans. 13, 615-618.

50. Lambeth, J.D. (1987) "Cytochrome P-450scc: Specificity and Properties of the Cholesterol Binding Site" Endocrine Research 12, 371-392.

51. Wilson, E., Laster, S.M., Gooding, L.R. and Lambeth, J.D. (1987) "Platelet-derived growth factor stimulates phagocytosis and blocks agonist-incuced activation of the neutrophil oxidative burst: A possible cellular mechanism to protect against oxygen radical damage" Proc. Nat. Acad. Sci., U.S.A. 84, 2213-2217.

52. Lambeth, J.D., Xu, X.X., and Glover (1987) "Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc: Evidence for an intramitochondrial cholesterol translocator" J. Biol. Chem. 262, 9181-9188.

53. Tuls, J., Geren, L., Lambeth, J.D. and Millett, F. (1987) "The Use of a Specific Fluorescence Probe to Study the Interaction of Adrenodoxin with Adrenodoxin Reductase and Cytochrome P-450scc" J. Biol. Chem. 262, 10020-10025.

54. Wilson, E., Rice, W.G., Kinkade, J.M., Jr., Merrill, A.H., Arnold, R.A., and Lambeth, J.D. (1987) "Protein Kinase C Inhibition by Sphingoid Long-Chain Bases: Effects on Secretion in Human Neutrophils" Arch. Biochem. Biophys. 259, 204-214.

55. Deli, E., Kiss, Z., Wilson, E., Lambeth, J.D., and Kuo, J.F. (1987) "Immunocytochemical Localization of Protein Kinase C in Resting and Activated Human Neutrophils" FEBS Lett. 221, 365-369.

56. Lambeth, J.D., Burnham, D.N. and Tyagi, S.R. (1988) "Sphinganine Effects on Chemoattractant-induced Diacylglycerol Generation, Calcium Fluxes, Superoxide Production, and on Cell Viability in the Human Neutrophil: Delivery of Sphinganine with Bovine Serum Alubumin Minimizes Cytotoxicity without Affecting Inhibition of the Respiratory Burst" J. Biol. Chem. 263, 3818-3822.

57. Tyagi, S.R., Tamura, M., Burnham, D. and Lambeth, J.D. (1988) "Phorbol Myristate Acetate Augments Chemoattractant-induced Diglyceride Generation in Human Neutrophils, but Inhibits Phosphoinositide Hydrolysis: Implications for the Mechanism of PMA Priming of the Respiratory Burst" J. Biol. Chem. 263, 13191-13198.

58. Nisimoto, Y., Tamura, M., and Lambeth, J.D. (1988) "A Menadione-Stimulated Pyridine Nucleotide Oxidase from Resting Bovine Neutrophil Membranes: Purification, Properties, and Immunochemical Cross-Reactivity with the Human Neutrophil NADPH Oxidase" J. Biol. Chem. 263, 11657-11663.

59. Lambeth, J.D. and Xu, X.X. (1989) "Cholesterol Sulfate: A Naturally-Occurring Inhibitor of Cholesterol Side-Chain Cleavage Which Functions at the Level of Intramitochondrial Cholesterol Translocation" Endocrine Research 15, 85-99.

60. Tamura, M., Tamura, T., Tyagi, S.R., and Lambeth, J.D. (1988) "The Superoxide-Generating Respiratory Burst Oxidase of Human Neutrophil Plasma Membrane: Phosphatidylserine as an Effector of the Activated Enzyme" J. Biol. Chem. 263, 17621-17626.

61. Lambeth, J.D. (1989) "Introduction to: Minireview Series on the Respiratory Burst Oxidase and its Regulation", J. Bioenergetics and Biomembranes 20, 633-635.

62. Lambeth, J.D. (1989) "Activation of the Respiratory Burst Oxidase in Neutrophils: On the Role of Membrane-Derived Second Messengers, Ca++ and Protein Kinase C" J. Bioenergetics and Biomembranes 20, 709-733.

63. Fowler, W.T.,Jr., Lambeth, J.D., and Powell, G.L. (1988) "Photoreactive Cardiolipin Analogs" Chem. Phys. Lipids 47, 261-271.

64. Lambeth, J.D. (1990) "Enzymology of Mitochondrial Cholesterol Side-Chain Cleavage by Cytochrome P-450scc" in Frontiers in Biotransformation, V. 4 (K. Ruckpaul, ed.) 58-100.

65. Merrill, A.H., Jr., Nimkar, S., Menaldino, D., Hannun, Y.A., Loomis, C., Bell, R.M., Tyagi, S.R., Lambeth, J.D., Stevens, V.L., Hunter, R., and Liotta, D.C. (1989) "Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds" Biochemistry, 28, 3138-3145.

66. Xu, X.X. and Lambeth, J.D. (1989) "Cholesterol Sulfate is a Naturally Occurring Inhibitor of Steroidogenesis in Isolated Rat Adrenal Mitochondria" J. Biol. Chem. 264, 7222-7227.

67. Tyagi, S.R., Burnham, D.N. and Lambeth, J.D. (1989) "On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-Diradylylycerols in Human Neutrophils: Selective Destruction of Diacyl Species Using Rhizopus Lipase" J. Biol. Chem. 264, 12977-12982.

68. Burnham, D.N., Tyagi, S.R., Uhlinger, D.J., and Lambeth, J.D. (1989) "Diacylglycerol Generation and Phosphoinositide Turnover in Human Neutrophils: Effects of Particulate versus Soluble Stimuli", Arch. Biochem. Biophys. 269, 345-353.

69. Uhlinger, D.J., Burnham, D.N., Mullins, R.E., Kalmar, J.R., Cutler, C.W., Arnold, R.R., Lambeth, J.D. and Merrill, A.H., Jr. "Functional Differences in Human Neutrophils Isolated Pre- and Postprandially" (1991) FEBS Lett. 286, 28-32.

70. Wilson, E., Wang, E., Mullins, R.E., Uhlinger, D.J., Liotta, D.C., Lambeth, J.D., and Merrill, A.H., Jr. (1988) "Modulation of Free Sphingosine Levels in Human Neutrophils by Phorbol Esters and Other Factors", J. Biol. Chem. 263, 9304-9309.

71. Robertson, D.G., DiGirolamo, M., Merrill, A.H., Jr., and Lambeth, J.D. (1989) "Insulin-Stimulated Hexose Transport and Glucose Oxidation in Rat Adipocytes is Inhibited by Sphingosine at a Step After Insulin Binding" J. Biol. Chem. 264, 6773-6779.

72. Xu, X., Xu, T., Robertson, D.G. and Lambeth, J.D. (1989) "GTP Stimulates Pregnenolone Generation in Isolated Rate Adrenal Mitochondria" J. Biol. Chem. 264, 17674-17680.

73. Tamura, M., Tamura, T., Burnham, D.N., Uhlinger, D.J., and Lambeth, J.D. (1989) "Stabilization of the Superoxide-Generating Respiratory Burst Oxidase of Human Neutrophil Plasma Membrane by Crosslinking with 1-Ethyl-3-(3-dimetylaminopropyl) Carbodiimide" Arch. Biochem. Biophys. 275, 23-32.

75. Tyagi, S.R., Winton, E.F. and Lambeth, J.D. (1989) "Granulocyte/macrophage colony-stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant" FEBS Lett. 257, 188-190.

76. Tyagi, S.R., Olson, S., Burnham, D.N. and Lambeth, J.D. (1991) "Cyclic AMP-elevating Agents Block Chemoattractant Activation of Diradylglycerol Generation by Inhibiting Phospholipase D Activation" J. Biol. Chem. 266, 3498-3504.

77. Burnham, D.N., Uhlinger, D.J., and Lambeth, J.D. (1990) "Diradylglycerol Synergizes with an Anionic Amphiphile to Activate Superoxide Generation and Phosphorylation of p47phox in a Cell-free System from Human Neutrophils" J. Biol. Chem. 265, 17550-17559.

78. Xu, T.S., Bowman, E., Glass, D.B. and Lambeth, J.D. (1991) "Stimulation of Adrenal Mitochondrial Cholesterol Side-Chain Cleavage by GTP, Steroidogenesis Activator Polypeptide (SAP), and Sterol Carrier Protein2: GTP and SAP Act Synergistically" J. Biol. Chem. 266, 6801-6807.

79. Olson, S.,Tyagi, S.R. and Lambeth, J.D. (1990) "Fluoride Activates Diradylglycerol and Superoxide Generation in Human Neutrophils via PLD/PA Phosphohydrolase-dependent and -independent Mechanism", FEBS Lett. 272, 19-24

80. Glass, D.B., Robertson, D.G., Xu, T., Bowman, E.P. and Lambeth, J.D. (1991) "Chemical Synthesis, Initial Conformational Studies, and Activity of Rat Steroidogenesis Activator Peptide and a Truncated Analog", Endocrine Research 17, 307-326.

81. Robertson, D.G., Perry, D. and Lambeth, J.D. (1991) "Inhibition of Mitochondrial Cholesterol Side-Chain Cleavage by Structural Analogs of Cholesterol Sulfate", Endocrine Research 17, 297-306.

82. Olson, S.C., Bowman, E.P. and Lambeth, J.D. (1991) "Phospholipase D Activation in a Cell-Free System from Human Neutrophils by PMA and GTPgS: Activation is Calcium-Dependent and Requires Protein Factors in Both the Plasma Membrane and Cytosol" J. Biol. Chem. 266, 17236-17242.

83. Uhlinger, D.J., Burnham, D.N. and Lambeth, J.D. (1991) "Nucleoside Triphosphate Requirements for Superoxide Generation and Phosphorylation in a Cell-Free System from Human Neutrophils: SDS and Diacylglycerol Activate Independently of Protein Kinase C" J. Biol. Chem. 266, 20990-20997.

84. Tyagi, S.R., Uhlinger, D.J., Van Dyke, T.E. and Lambeth, J.D. (1992) "Altered Diacylglycerol Level and Metabolism by Diglyceride Kinase in Neutrophils from Individuals with Localized Juvenile Periodontitus" Infection and Immunity 60, 2481-2487.

85. Tamura, M., Tamura, T., Kugi, M., Takeshita,M. and Lambeth, J.D. (1992) "Stabilization of Human Neutrophil NADPH-Oxidase Activated in a Cell-Free System by Cross-Linking", J. Biol. Chem. 266, 7529-7538.

86. Stevens, V.L., Xu, T.S. and Lambeth, J.D. (1992) "Cholesterol pools in rat adrenal mitochondria: Use of cholesterol oxidase to infer a complex pool structure". Endocrinology 130, 1557-1563.

87. Tyagi, S.R., Neckelmann, N., Uhlinger, D.J., Burnham, D.N. and Lambeth, J.D. (1992) "Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: Effects of guanine 5'O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile". Biochemistry 31, 2765-2774.

88. Stevens, V.L., Xu, T.S. and Lambeth, J.D. (1993) "Cholesterol trafficking in steroidogenic cells: Reversible cycloheximide-dependent accumulation of cholesterol in a "pre-steroidogenic pool" E.J. Biochem. 216, 557-563.

89. Perry, D.K., Hand, W.L., Edmondson, D.E. and Lambeth, J.D. (1992) "On the role of phoshpolipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase: Inhibition by phosphatidic acid phosphohydrolase inhibitors". J. Immunol. 149, 2749-2758.

90. Henriques, R.G., Widlanski, T.S., Xu, T. and Lambeth, J.D. (1992) "Inhibition of Steroid Biosynthesis by Steroid Sulfonates" J. Am. Chem. Soc. 114, 7311-7313.

91. Uhlinger, D.J., Inge, K.L., Kreck, M.L., Tyagi, S.R., Neckelmann, N. and Lambeth, J.D. (1992) "Reconstitution and characterization of the human neutrophil respiratory burst oxidase using recombinant p47-phox, p67-phox and plasma membrane" Biochem. Biophys. Res. Commun. 186, 509-516.

92. Uhlinger, D.J., Tyagi, S.R., Inge, K.L. & Lambeth, J.D. (1992) "Guanine nucleotides regulate the assembly of the Human Neutrophil Respiratory Burst Oxidase: Evidence for G Protein Regulation of the Binding of p67-phox and p47-phox" J. Biol. Chem. 268, 8624-8631.

93. Lambeth, J.D. (1992) "Receptor-regulated phospholipases and their generation of lipid mediators, which activate protein kinase C" in Protein Kinase C (J.F. Kuo, Ed.), Oxford University Press. pp. 121-170 .

94. Perry, D., Widlanski, T.S., and Lambeth, J.D. (1992) "A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid" J. Biol. Chem. 268, 25302-25310.

95. Kreck, M.L., Uhlinger, D.J., Tyagi, S.R., Inge,K.L. and Lambeth,J.D. (1993) "Participation of the small molecular weight GTP binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase: Inhibition by a C-terminal Rac peptide" J. Biol. Chem. 269, 4161-4168.

96. Bowman,E.P., Uhlinger, D.J. and Lambeth,J.D. (1993) "Neutrophil Phospholipase D is activated by a membrane-associated Rho-family small molecular weight GTP-binding protein" J. Biol. Chem. 268, 21509-21512.

97. Freeman, J.L.R., Kreck, M.L., Uhlinger, D.J., and Lambeth, J.D. (1994) "Ras effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex" Biochemistry 33, 13431-13435.

98. Uhlinger, D.J., Taylor, K.L. and Lambeth, J.D. (1994) "p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex" J. Biol. Chem. 269, 22095-22098.

99. Bowman, E. and Lambeth, J.D. (1994) "Neutrophil phospholipase D: Inhibition by RhoGDI and Stimulation by RhoGDS" Methods in Enzymology, in press.

100. Uhlinger, D.J., Tyagi, S.R. and Lambeth, J.D. (1995) "On the mechanism of inhibition of the neutrophil respiratory burst oxidase by a peptide from the C-terminus of the large subunit of cytochrome b558" Biochemistry 34, 524-527.

101. Lambeth, J.D., Kwak, J.Y., Bowman, E.P., Perry, D., Uhlinger, D.J. and Lopez, I. (1995) "ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D" J. Biol. Chem. 270, 2431-2434.

102. Lopez, I., Burns, D.J. and Lambeth, J.D. (1995) "Regulation of phospholipase D by protein kinase C in human neutrophils: Conventional isoforms of protein kinase C phosphorylate, a phospholipase D-related component in the plasma membrane" J. Biol. Chem. 270, 19465-19472.

103. Nisimoto, Y., Otsuka-Murakami, H.and Lambeth, J.D. (1995) "Reconstitution of flavin-depleted neutrophil flavocytochrome b558 with 8-mercapto-FAD and characterization of the flavin-reconstituted enzyme" J. Biol. Chem. 270, 16428-16434.

104. Kwak, J.Y., Lopez, I., Uhlinger, D.J., Ryu, S.H. and Lambeth, J.D. (1995) "RhoA and a cytosolic 50-kDa factor reconstitute GTPgS-dependent phospholipase D activity in human neutrophil subcellular fractions" J. Biol. Chem. 270, 27093-27098.

105. Kim, J.H., Suh, Y.J., Lee, T.G., Kim, Y., Bae, S.S. and Lambeth, J.D. (1996) "Inhibition of phospholipase D by a protein factor from bovine brain cytosol: Partial purification and characterization of the inhibition mechanism" J. Biol. Chem. 271, 25213-25219.

106. Freeman, J.L., Abo, A., and Lambeth, J.D. (1996) "Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65" J. Biol. Chem. 271, 19794-19801

107. Freeman, J.L. and Lambeth, J.D. (1996) "NADPH oxidase activity is independent of p47-phox in vitro" J. Biol. Chem. 271, 22578-22585.

108. Xu, X.X., Yi.,T. Tang, B. and Lambeth, J.D. (1996) "Association of mDab and Grb2 is mediated through interaction between proline-rich motifs and SH3 domains" submitted.

109. Kreck, M.L., Freeman, J.L., Abo, A. and Lambeth, J.D. (1996) "Membrane association of Rac is required for high activity of the respiratory burst oxidase" Biochemistry 35, 15683-15692.

110. Seo, J.K., Choi, S.-Y., Kim, Y., Baek, S.H., Kim, K.-T., Chae, C.-B., Lambeth, J.D., Suh, P.-G., and Ryu, S.H. (1996) "A peptide with unique receptor specificity: Stimulation of phosphoinositide hydrolysis and induction of superoxide generation in human neutrophils" J. Biol. Chem. 271, 25213-25219.

111. Lambeth, J.D., and Ryu, S.H. (1996) "Glycerolipids in Signal Transduction." Biochemistry of Lipids, Lipoproteins and Membranes," (D.E. Vance and J.E. Vance, Eds.), Elsevier Science B.V., New York, 237-254.

112. Nisimoto, Y., Freeman, J.F.R., Motalebi, S.A., Hirshberg, M. and Lambeth, J.D. (1997) "Rac binding to p67phox: Structural Basis for Ineractions of the Rac1 Effector Region and Insert Region with Components of the Respiratory Burst Oxidase" J. Biol. Chem. 271, in press.

113. Baek, S-H., Kwak, J-Y., Lee, S.H., Lee, Taehoon, Ryu, S.H., Uhlinger, D.J., Lambeth, J.D. (1997) "Lipase Activities of p37, the Major Envelope Protein of Vaccinia Virus" J. Biol.Chem. 272, 32042-32049.

114.Xu, X-X, Yi, T., Tang, B. and Lambeth, J.D. (1998) "Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2" Oncogene 16, 1561-1569.

115. Lopez, I., Arnold, R.S. and Lambeth, J.D. (1998) "Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2)" J. Biol. Chem. 273, 12846-12852.

116. Han, C-H, Freeman, J.L.R., Lee, T., Motalebi, S.A. And Lambeth, J.D. (1998) "Regulation of the Neutrophil Respiratory Burst Oxidase." J. Biol. Chem. 273, 16663-16668.

117. Kim, J.H., Lee, S.D., Han, J.M., Lee, T.G., Kim, Y., Park, J.B., Lambeth, J.D., Suh, P-G and Ryu, S.H. (1998) "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and Ra1A" FEBS Lett. 430, 231-235.

118. Suh, Y-A., Arnold, R.S., Lassegue, B., Shi, J., Xu, Xiangxi., Sorescu, D., Chung, A.B., Griendling, K.K., and Lambeth, J.D. (1999) "Cell transformation by the superoxide-generating oxidase Mox1" Nature. 401.

119. Nisimoto, Y., Motalebi, S., Han, C.-H. and Lambeth, J.D. (1999) "The p67phox Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochrome b558" J. Biol. Chem., 274, 22999-23005.

120. Suh, Y.-A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Griendling, K.K. and Lambeth, J.D. (1999) "Cell Transformation by a novel superoxide-generating oxidase" Nature, 401, 79-82.

121. Kim, J.H., Kim, Y., Lee, S.D., Lopez, I., Arnold, R.S, Lambeth, J.D., Suh, P.-G. and Ryu, S.H. (1999) "Selective activation of phospholipase D2 by unsaturated fatty acid" FEBS Lett. 454, 42-46.

122. Lambeth, J.D. (2000) "Regulation of the Phagocyte Respiratory Burst Oxidase by Protein Interactions" J. Biochemistry & Molecular Biology, 33, 427-439.

123. Lambeth, J.D., Cheng, G., Arnold, R.S., and Edens, W.A. (2000) " Novel homologs of gp91phox" Trends in Biochemical Sciences 25

124. Tamura, M., Kai, T., Tsunawaki, S., Lambeth, J.D., Kameda, K. (2000) "Direct Interaction of Actin with p47phox of Neutrophil NADPH Oxidase" Biochemical & Biophysical Communications 276, 1186-1190.

125. Kim, Y., Kwak, J.-Y., Lee, T., Lopez, I., Lambeth, J.D., Suh, P.-G., and Ryu, S.H. "Activation of Neutrophil Membrane Phospholipase D by Soluble Proteins: Comparison of Cytosolic Neutrophil 50 kDa Factor, ADP-ribosylation Factor and a Novel Brain Factor" Korean Journal of Immunology, 21, 183-191.

126. Lambeth, J.D., Cheng, G., Arnold, R.S., Edens, W.A. (2000) "Novel homologs of gp91phox" Trends in Biochemical Sciences 25 (10): 459-61.

127. Lassegue, B., Sorescu, D., Yin, Q., Akers, M., Zhang, Y., Grant, S.L., Lambeth, J.D., and Griendling, K.K. (2000) "The Novel gp91phox Homologues in Vascular Smooth Muscle Cells: Nox1 Mediates Angiotensin-II Induced Superoxide Formation and Redox-Sensitive Signaling Pathways" Circ Res 88 (9): 888-894.

128. Arnold, R.S., Shi, J., Murad, E., Whalen, A.M., Sun, C.Q., Polavarapu, R., Parthasarathy, S., Petros, J.A., Lambeth, J.D. (2000) "Hydrogen Peroxide Mediates the Cell Growth and Transformation Caused by the Mitogenic Oxidase Nox1" PNAS 98 (10): 5550-5555.

129. Cheng, G., Cao, Z., Xu, X., Van Meir, E., Lambeth, J.D. (2000) "Homologs of gp91phox: Cloning and Tissue Expression of Nox3, Nox4, and Nox5" Gene 269 (2001): 131-140.

130. Jin, Z.-G., Melaragno, M., Liao, D.-F., Yan, Chen, Haendeler, J., Suh, Y.-A., Lambeth, J.D. and Berk, B. (2000) "Cyclophilin A is a Secreted Growth Factor Induced by Oxidative Stress" Circ. Res. 87 (9): 789-96.

131. Han, C.-H., Nisimoto, Y., Lee, S.-H., Kim, E.T., Lambeth, J.D. (2000) "Characterization of the Flavoprotein domain of gp91phox which has NADPH Diaphorase Activity" J. Biochem (Tokyo) 129 (4): 513-520.

132.Cheng, G., Cao, Z., Xu, X., Van Meir, E.G., and Lambeth, J.D. (2001) "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5" Gene 269

133.Arnold, R.S., Shi, J., Murad, E., Whalen, A.M., Sun, C.Q., Polavarapu, R., Parthasarathy, S., Petros, J.A., and Lambeth, J.D. (2001) "Hydrogen Peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1" PNAS

134.Edens, W.A., Sharling, L., Cheng, G., Shapira, R., Kinkade, J.M., Lee, T., Edens, H.A., Tang, X., Sullards, C., Flaherty, D.B., and Lambeth, J.D. (2001) "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox" JCB 154

135. Klafter, R., Govindajaran, B., McLaughlin, E.R., Brown, L.F., Cohen, C., Moses, M., Kilroy, S., Arnold, R.S., Lambeth, J.D., Arbiser, J.L. (2001) "Reactive Oxygen Species Induce the Angiogenic Switch" submitted

136. Szöcs, K., Lasségue, B., Valppu, L., Hilenski, L., Sorescu, D., Lambeth, J.D., Griendling, K.K. (2001) "Differential upregulation of Nox1, Nox4 and p22phox following ballon injury: evidence for diverse functions of vascular NAD(P)H oxidases in restenosis" submitted

137. Edens, W.A., Sharling, L., Cheng, G., Shapira, R., Kinkade, J.M., Lee, T., Edens, H.A., Tang, X., Flaherty, D.B., Benian, G., Lambeth, J.D. (2001) "Tyrosine Cross-Linking of Extracellular Matrix is Catalyzed by Duox, A Multidomain Oxidase/Peroxidasse with Homology to the Phagocyte Oxidase Subunit gp91phox" J. Cell Biology 154, 879-892.

138. Price, M.O., McPhail, L.C., Lambeth, J.D., Han, C.-H., Knaus, U.G., Dinauer, M.C. (2001) "Creation of a Genetic System for Analysis of the Phagocyte Respiratory Burst: High Level Reconstitution of the NADPH Oxidase in a Non-Hematopoietic System" submitted


Last Update: August 27, 2001