Profile of a Pathology Faculty Member

Pathology Faculty Photo

Debra Saxe, PhD

Clinical Cytogenetics

Associate Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Associate Professor, Dept. of Pediatrics, Emory University School of Medicine
  • Director of Oncology Cytogenetics, Emory University School of Medicine

Pathology Division(s):
Clinical Pathology

Email Address:   dsaxe01@emory.edu

Education:

BA   University of Texas at Austin, Biology, 1971 - 1973
MS   University of Arizona, Genetics, 1974 - 1977
PhD   University of Arizona, 1977 - 1979

Research Interests:

- Cancer Cytogenetics and Cytogenomics My research interests primarily involve genetic testing in leukemia and brain tumors for diagnosis, prognosis, disease progression and response to therapies. I am a member of the Brain Tumor Working Group, sponsored by Cancer Genomic Consortium, which is creating report guidelines, and tools to aid in genetic analysis for brain tumors. I am also currently working with multiple research projects to determine if cytogenomic microarray can more easily distinguish differences within tumor subtypes with similar histology.

Clinical Focus:

I serve as Medical Director of the Oncology Cytogenetics Laboratory, at Emory University Hospital. My particular clinical interest is to develop and improve genetic testing for cancer by raising the awareness of the usefulness of genetic tools in determining diagnoses, prognoses, and therapies. I have continued to expand both the analytical tools and the types of tumors utilizing genetic testing. I am also interested in quality improvement, test utilization, and cost effectiveness of various cytogenetic and molecular cytogenetic tests. I have collaborated on multiple American College of Medical Genetics and Genomics Laboratory Standards and Guidelines which include prenatal diagnosis and solid tumors genetic testing.

I serve as Medical Director of the Oncology Cytogenetics Laboratory, at Emory University Hospital. My particular clinical interest is to develop and improve genetic testing for cancer by raising the awareness of the usefulness of genetic tools in determining diagnoses, prognoses, and therapies. I have continued to expand both the analytical tools and the types of tumors utilizing genetic testing. I am also interested in quality improvement, test utilization, and cost effectiveness of various cytogenetic and molecular cytogenetic tests. I have collaborated on multiple American College of Medical Genetics and Genomics Laboratory Standards and Guidelines which include prenatal diagnosis and solid tumors genetic testing.

Specialty Boards:

  • Medical Genetics American Board of Medical Genetics, Cytogenetics

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Mitchell SG, Bunting ST, Saxe D, Olson T, Keller FG: A variant c-KIT mutation, D816H, fundamental to the sequential development of an ovarian mixed germ cell tumor and Systemic mastocytosis with CMML. Pediatric Blood Cancer, 2017: Apr;64(4).
  • Braxton DR, Saxe D, Damjanov N, Stashek K, Shroff S, Morrissette JD, Tondon R, Furth,FF: Molecular and cytogenomic profiling of hepatic adenocarcinoma expressing inhibin, a mimicker of neuroendocrine tumors: proposal to reclassify a "cholangioblastic variant of intrahepatic cholangiocarcinoma". Human Pathol, 2017: Feb 20.
  • Fisher KE, Zhang L, Wang J, Smith GH, Newman S, Schneider TM, Pillai RN, Kudchadkar RR, Owonikoko TK, Ramalingam SS, Lawson DH, Delman KA, El-Rayes BF, Wilson MM, Sullivan HC, Morrison AS, Balci S, Adsay NV, Gal AA, Sica GL, Saxe DF, Mann KP, Hill CE, Khuri FR, Rossi MR: Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal malignancies. J Molec Pathol, 2016: Mar;18(2):299-315.
  • Cooley LL, Morton CC, Sanger WG, Saxe DF, Mikhail FM, A Working Group of the American College of Medical Genetics & Genomics (ACMGG) Laboratory Quality Assurance Committee: Section E6.5-6.8 of the American College of Medical Genetics and Genomics (ACMG) Technical Standards and Guidelines: Chromosome Studies of Lymph Node and Solid Tumor Acquired Chromosomal Abnormalities. Genet Med, 2016: 18(6)643-648.
  • Sullivan HC, Fisher KE, Hoffa AL, Wang J, Saxe D, Siddiqui MT, Cohen C: The role of immunohistochemical analysis in the evaluation of EML4-ALK gene rearrangement in lung cancer, 2015: Apr:23(4):239-44.
  • Tadesse T, Gearing M, Senitzer D, Saxe D, Brat D, Bray R, Gebel H, Hill C, Boulis N: Analysis of graft survival in a trial of stem cell transplant in amyotrophic lateral sclerosis. Ann Clin Transl Neurol, 2014: Nov:1(11):900-8.
  • Saxe DF, Persons DL, Wolff DJ, Theil KS: Validation of performance specifications and fluorescence in situ testing of an analyte specific reagent: Detection of abnormalities involving the Mixed Lineage Leukemia gene (MLL). Arch Pathol Lab Med, 2012: 136(1):47-52.

Book Chapters -

  • Saxe D, May K, Priest J. 2017. General Cell Culture Principles and Fibroblast Culture, The AGT Cytogenetics Laboratory Manual, fourth edition.
  • May K, Saxe D, Priest J. 2017. Prenatal Chromosome Diagnosis, The AGT Cytogenetics Laboratory Manual, fourth edition.
  • Mann KP, and Saxe DF. 2010. Molecular Pathology of Acute Myeloid Leukemias, Hematopathology: Genomic Mechanisms of Neoplastic Diseases. Humana Press 2010, 127-155.

Other Publications -

  • Neill S, Saxe D, Rossi M, Schniederjan M, Brat DJ: Genomic Analysis in the Practice of surgical neuropathology: The Emory experience. Arch Path Lab Med, 2017: 141(3):355-365.
  • Li S, Jaye DL, Bradley K, Zhang L, Deeb G, Mann K, Saxe D, Hill CE: Multimodality technologies in the assessment of hematolymphoid neoplasms. Arch Path Lab Med, 2017: 141(3):341-354.