Profile of a Pathology Faculty Member

Pathology Faculty Photo

Adeboye O Osunkoya, MD

Genitourinary Pathology
Surgical Pathology

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Professor of Urology, Emory University School of Medicine
  • Director, Urologic / Genitourinary Pathology, Emory University School of Medicine
  • Director, Pathology Grand Rounds / Distinguished Visiting Professorship Program, Emory University School of Medicine
  • Director, Surgical Pathology Fellowship Program, Emory University School of Medicine

Pathology Division(s):
Anatomic Pathology

Email Address:   adeboye.osunkoya@emory.edu

Education:

  MBBS University of Ibadan College of Medicine, Oyo State, Nigeria, - 1998
  Intern, University College Hospital, Ibadan, - 1999
  Research Fellow, Institute of Child Health, University College Hospital, Ibadan, - 2000
  Resident, Anatomic and Clinical Pathology, University College Hospital, Ibadan, 2000 - 2002
  Resident, Anatomic and Clinical Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2002 - 2004
  Chief Resident, Anatomic and Clinical Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2004 - 2006
  Clinical and Research Fellow, Division of Genitourinary Pathology, The Johns Hopkins Hospital, Baltimore, MD, 2006 - 2007

Research Interests:

- Urologic/Genitourinary Pathology My research interests are mainly in the field of Urologic/Genitourinary pathology. Prostate: We have studied the largest series to date of mucinous prostate cancer, colon cancer with prostatic involvement, primary mucin-producing urothelial-type adenocarcinoma of prostate and prostate cancer with aberrant p63 expression. We have also analyzed the expression of MUC-2, VEGF and ZEB-1 in prostate cancer, and have utilized multiplexed quantum dots in molecular mapping of tumor heterogeneity on tissue specimens of patients with prostate cancer. Kidney: We have analyzed diagnostic biomarkers for renal cell carcinoma (RCC), based on a selection utilizing novel bioinformatics systems for microarray data analysis. We have also studied the utility of Claudin 7 and 8 in the distinction between renal oncocytoma and chromophobe RCC, and the expression of PAX-2 and CA-IX in RCC. In addition, we are one of the first groups to confirm the distinction between tubulocystic carcinoma and collecting duct carcinoma of the kidney at the molecular level, based on comparison of gene expression profiles. Urinary Bladder: We are one of the first groups to describe a unique variant of bladder cancer (urothelial carcinoma with villoglandular differentiation). We have also analyzed one of the largest series to date of plasmacytoid urothelial carcinoma and smooth muscle neoplasms of the urinary bladder. Testis: We have analyzed the significance of rete testis involvement by malignant germ cell neoplasia and/or intratubular germ cell neoplasia. We have also studied lymphoid neoplasms of the urinary tract and male genital organs.

Clinical Focus:

My clinical focus is in Surgical Pathology with major emphasis on Urologic/Genitourinary Pathology. I sign out general Surgical Pathology cases and frozen sections at both Emory University Hospital and the Veterans Affairs Medical Center. I also sign out autopsies, gynecologic and non-gynecologic cytology (including urine cytology) cases at the latter. I handle in house Urologic/Genitourinary Pathology consultation cases from Emory University Hospital, Veterans Affairs Medical Center, Emory Midtown Hospital, Grady Hospital and Children's Healthcare of Atlanta at Egleston and Scottish Rite. In addition, I offer expert consultation from outside institutions in the area of Urologic/Genitourinary Pathology (please see separate website link: http://pathology.emory.edu/ExpertConsultation_Forms.html). I have a secondary appointment in the department of Urology and I am active in their tumor boards at both the Emory University Hospital and the Veterans Affairs Medical Center.

Honors / Awards:

  • Elected Member, Board of Directors, United States and Canadian Academy of Pathology, 2017-
  • 2015 Arthur Purdy Stout Prize. This annual award recognizes significant career achievements in Surgical Pathology by a Surgical Pathologist (less than 45 years old) whose publications have had a major impact on diagnostic pathology. United States and Canadian Academy of Pathology Meeting, Boston, MA, 2015
  • Chair, F. Stephen Vogel Award Committee, United States and Canadian Academy of Pathology, 2014-2016
  • Invited Scholar, Inaugural Set, Emory Clinic Physician Leadership Development Program, 2013-2014
  • Chair, Excellence in Urological Pathology Resident/Fellow Research Award Committee, International Society of Urological Pathology, 2013-
  • Member, Education Committee, United States and Canadian Academy of Pathology, 2012-2016
  • Member, Editorial Board, Human Pathology, 2012-
  • Member, Abstract Review Board, College of American Pathologists, 2012-
  • Member, Editorial Board, Pathology, 2012-
  • Section Editor, Urologic Pathology, Archives of Pathology and Laboratory Medicine, 2012-
  • Invited Speaker, 20th Anniversary of the International Society of Urological Pathology, Vancouver, Canada, 2012
  • Member, Stowell-Orbison Award Committee, United States and Canadian Academy of Pathology, 2011-2012
  • Visiting Professor, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2011
  • Member, Abstract Review Board, United States and Canadian Academy of Pathology, 2011
  • Member, Editorial Board, International Journal of Clinical and Experimental Pathology, 2010-
  • Benjamin Castleman Award, United States and Canadian Academy of Pathology, 2010
  • NCI Prostate Specialized Programs of Research Excellence (SPORE) Grants Program, Ad Hoc Reviewer, 2010
  • Invited Scholar, Emory University School of Medicine, Junior Faculty Development Course, 2010
  • Golden Apple Award for Excellence in Resident Education. Department of Pathology, Emory University School of Medicine, Atlanta, GA, 2009-2010
  • Young Investigator Award in Clinical Research, Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, 2007
  • Perry Lambird Award, Outstanding Resident in Clinical Pathology, University of Oklahoma Health Sciences Center, OK, 2006
  • Parker-Heartland Award, Outstanding Resident in Anatomic Pathology, University of Oklahoma Health Sciences Center,OK, 2005
  • Donald West King Fellow, Gastrointestinal Pathology Division, Armed Forces Institute of Pathology, Washington, DC, 2005
  • Chief Resident, Anatomic and Clinical Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2004-2006
  • Member, Residents Council, University of Oklahoma Health Sciences Center, OK, 2003/2004
  • Nancy K. Hall Award for Most Outstanding First Year Resident, Department of Pathology, University of Oklahoma Health Sciences Center, OK, 2003

Specialty Boards:

  •  Anatomic and Clinical Pathology (Recertified 2013: Anatomic and Clinical Pathology)

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Schneider TM, Osunkoya AO. ERG expression in intraductal carcinoma of the prostate: comparison with adjacent invasive prostatic adenocarcinoma. Mod Pathol. 2014;27(8):1174-8.
  • Fisher KE, Yin-Goen Q, Alexis D, Sirintrapun JS, Harrison W, Benjamin Isett R,Rossi MR, Moreno CS, Young AN, Osunkoya AO. Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. Mod Pathol. 2014;27(2):222-30.
  • Fatima N, Osunkoya AO. GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. Hum Pathol. 2014;45(8):1625-9.
  • Ehsani L, Osunkoya AO. Human epidermal growth factor receptor 2 expression in urothelial carcinoma of the renal pelvis: correlation with Clinicopathologic parameters. Int J Clin Exp Pathol. 2014;7(5):2544-50.
  • Long Q, Xu J, Osunkoya AO, Sannigrahi S, Johnson BA, Zhou W, Gillespie T, Park JY, Nam RK, Sugar L, Stanimirovic A, Seth AK, Petros JA, Moreno CS. Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence. Cancer Res. 2014;74(12):3228-37.
  • Ehsani L, Osunkoya AO. Expression of MLH1 and MSH2 in urothelial carcinoma of the renal pelvis. Tumour Biol. 2014;35(9):8743-7.
  • Williamson SR, Wang M, Montironi R, Eble JN, Lopez-Beltran A, Zhang S, Fan R, Wang L, Osunkoya AO, Koch MO, Cheng L. Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations. Mod Pathol. 2014;27(11):1540-8.
  • Karram S, Kao CS, Osunkoya AO, Ulbright TM, Epstein JI. Idiopathic granulomatous orchitis: morphology and evaluation of its relationship to IgG4 related disease. Hum Pathol. 2014;45(4):844-50.
  • Shrewsberry AB, Osunkoya AO, Jiang K, Westby R, Canter D, Pattaras J, Turgeon N, Master VA, Ogan K. Renal cell carcinoma in patients with end-stage renal disease has favorable overall prognosis. Clin Transplant. 2014;28(2):211-6.
  • Ananthanarayanan V, Pan Y, Tretiakova M, Amin MB, Cheng L, Epstein JI, Grignon DJ, Hansel DE, Jimenez RE, McKenney JK, Montironi R, Oliva E, Osunkoya AO, Rao P, Reuter VE, Ro JY, Shen SS, Srigley JR, Tsuzuki T, Yao JL, Antic T, Haber M, Taxy JB, Paner GP. Influence of histologic criteria and confounding factors in staging equivocal cases for microscopic perivesical tissue invasion (pT3a): an interobserver study among genitourinary pathologists. Am J Surg Pathol. 2014;38(2):167-75.
  • Kothari S, Phan JH, Stokes TH, Osunkoya AO, Young AN, Wang MD. Removing batch effects from histopathological images for enhanced cancer diagnosis. IEEE J Biomed Health Inform. 2014;18(3):765-72.
  • Matoso A, Chen S, Plaza JA, Osunkoya AO, Epstein JI. Symplastic leiomyomas of the scrotum: a comparative study to usual leiomyomas and leiomyosarcomas. Am J Surg Pathol. 2014;38(10):1410-7.
  • Guo J, Tretiakova MS, Troxell ML, Osunkoya AO, Fadare O, Sangoi AR, Shen SS, Lopez-Beltran A, Mehra R, Heider A, Higgins JP, Harik LR, Leroy X, Gill AJ, Trpkov K, Campbell SC, Przybycin C, Magi-Galluzzi C, McKenney JK. Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients. Am J Surg Pathol. 2014;38(11):1457-67.
  • Iczkowski KA, Egevad L, Ma J, Harding-Jackson N, Algaba F, Billis A, Camparo P, Cheng L, Clouston D, Comperat EM, Datta MW, Evans AG, Griffiths DF, Guo CC, Hailemariam S, Huang W, Humphrey PA, Jiang Z, Kahane H, Kristiansen G, La Rosa FG, Lopez-Beltran A, MacLennan GT, Magi-Galluzzi C, Merrimen J, Montironi R, Osunkoya AO, Picken MM, Rao N, Shah RB, Shanks JH, Shen SS, Tawfik OW, True LD, Van der Kwast T, Varma M, Wheeler TM, Zynger DL, Sahr N, Bostwick DG. Intraductal carcinoma of the prostate: interobserver reproducibility survey of 39 urologic pathologists. Ann Diagn Pathol. 2014;18(6):333-42.
  • Champion A, Guolan Lu, Walker M, Kothari S, Osunkoya AO, Wang MD. Semantic interpretation of robust imaging features for Fuhrman grading of renal carcinoma. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:6446-9.

Book Chapters -

  • Hoon TP, Osunkoya AO. Secondary/Metastatic Tumours involving the Prostate. WHO Classification of Tumours of the Urinary System and Male Genital Organs, IARC Press, Lyon, 2016.
  • Osunkoya AO, Humphrey PA. Haematopoietic and Lymphoid Tumours of the Urinary Tract. WHO Classification of Tumours of the Urinary System and Male Genital Organs, IARC Press, Lyon, 2016.
  • Master VA, Huang J, Magi-Galluzzi C, Osunkoya AO. Management Implications Associated with Unusual Morphologic Entities of the Prostate. Genitourinary Pathology. Practical Advances. Edited by Magi-Galluzzi C, Przybycin CG. Springer 2015.
  • Osunkoya AO, Magi-Galluzzi C. Unusual Epithelial and Non-Epithelial Neoplasms of the Prostate. Genitourinary Pathology. Practical Advances. Edited by Magi-Galluzzi C, Przybycin CG. Springer 2015.
  • Wood H, Angermeier K, Osunkoya AO. Non-Neoplastic and Neoplastic Urethral Disease. The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management. Edited by Hansel DE, McKenney JK, eds. Springer 2013
  • Osunkoya AO. Prostatic adenocarcinoma, mucinous variant. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Nonprostatic adenocarcinoma involving the prostate. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Multilocular cystic renal cell carcinoma. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Papillary adenoma. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Urothelial carcinoma with villoglandular differentiation. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Urothelial carcinoma with inverted growth pattern. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Malakoplakia. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Klinefelter Syndrome. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Sclerosing Sertoli cell tumor. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Paratesticular Liposarcoma. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Paratesticular Rhabdomyosarcoma. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Penile squamous hyperplasia. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Penile Genital melanocytic macule/lentiginosis. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Leiomyosarcoma of the bladder. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Osunkoya AO. Leiomyoma of the bladder. Uropathology (High Yield Pathology). Edited by Zhou M, Netto GJ, Epstein JI. Elsevier, Philadelphia, 2012.
  • Thor AD, Osunkoya AO. Chapter 19 (The Breast) Rubin's Pathology Clinicopathologic Foundations of Medicine. 5th Edition. Published March 2007.

Other Publications -

  • Amin MB, Gupta R, Osunkoya AO, Hes O, Billis A, Bacchi CE, Hansel D, Zhou M, deCastro MG, Moch H, Salles P, Cabrera RA, Gown AM. Carcinoma of Collecting Ducts of Bellini: Analysis of 27 Distinctive Cases of Renal Cell Carcinoma with Aggressive Clinical Behavior. Mod Pathol 2009; 22: 157A.
  • Schniederjan SD, Osunkoya AO. Lymphomas of the Genitourinary Tract: A Clinicopathologic Study of 40 Cases. Mod Pathol 2009; 22: 192A.
  • Netto GJ, Wang W, Brownlee NA, Osunkoya AO, Hicks J, Sharma R, Albadine R. PAX8 (+)/p63 (-) Immunostaining Pattern in Renal Collecting Duct Carcinoma (CDC): A Useful Immunoprofile in the Differential Diagnosis of CDC vs Urothelial Carcinoma of Upper Urinary Tract. Mod Pathol 2009; 22: 186A.
  • Young AN, Yin-Goen Q, Phan JH, Moffitt R, Wang MD, Osunkoya AO. Novel Immunohistochemical Biomarkers for Renal Cell Carcinoma Derived from Expression Microarray Data. Mod Pathol 2009; 22: 202A.
  • Moreno CS, Henderson VM, Zhou W, Williams D, Laycock N, Kitayama H, Osunkoya AO. RAP1 Signaling in Prostate Cancer Progression. Mod Pathol 2009; 22: 185A.
  • Jani JC, Cohen C, Jehnazeb K, Lawson D, Osunkoya AO. Neuroendocrine, Proliferative and Apoptotic Markers in Prostatic Adenocarcinoma and Small Cell Carcinoma of the Prostate: A Tissue Microarray Analysis of 64 Cases. Mod Pathol 2009; 22: 174A.
  • Lotan TL, Osunkoya AO, DeMarzo AM, Netto GJ, Epstein JI. Prostate Adenocarcinomas Aberrantly Expressing p63 Have a Luminal Cell Phenotype. Mod Pathol 2009; 22: 180A.
  • Osunkoya AO, Young AN, Wang W, Netto GJ, Epstein JI. Comparison of Gene Expression Profiles in Tubulocystic Carcinoma and Collecting Duct Carcinoma of the Kidney. Mod Pathol 2009; 22: 187A.
  • Lim M, Adsay NV, Grignon DJ, Osunkoya AO. Urothelial Carcinoma with Divergent Villoglandular Differentiation: A Study of 14 Cases. Mod Pathol 2009; 22:179A.
  • Osunkoya AO, Hansel DE, Sun X, Netto GJ, Epstein JI. Aberrant Diffuse Expression of p63 in Adenocarcinoma of the Prostate on Needle Biopsy and Radical Prostatectomy: Report of 21 cases. Modern Pathology 2008; 21(1S): 174A-175A.
  • Yoon GS, Wang W, Osunkoya AO, Lane Z, Epstein JI. Residual Tumor Potentially Left Behind after Local Ablation Therapy in Prostate Adenocarcinoma. Modern Pathology 2008; 21(1S): 192A.
  • Young AN, Cohen C, Lawson D, Picken MM, Amin MB, Osunkoya AO. Claudin-7 and Claudin-8: Immunohistochemical Markers for the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Oncocytoma. Modern Pathology 2008; 21(1S): 192A.
  • Smith SL, Adsay NV, Cohen C, Epstein JI, Smith SL. Osunkoya AO. MUC2 Expression in Primary Mucinous and Nonmucinous Adenocarcinoma of the Prostate: An analysis of 50 cases on radical prostatectomy. Modern Pathology 2008; 21(1S): 182A.
  • Osunkoya AO, Nielsen ME, Epstein JI. Prognosis of Mucinous Adenocarcinoma of the Prostate Treated by Radical Prostatectomy: A Study of 47 Cases. Modern Pathology 2008; 21(1S): 175A.
  • Osunkoya AO, Hansel DE, Parwani AV, Ali TZ, Tamas EF, Untawale VG, Kahane H, Epstein JI. The Symphony" Protocol for H&E Staining of Prostatic Adenocarcinoma on Needle Biopsy: A Multicenter Analysis of 120 cases Modern Pathol 2007; 20(2):167A-168A.
  • Osunkoya AO, Netto GJ, Epstein JI. Colorectal Adenocarcinoma Involving the Prostate: Report of 9 Cases. Modern Pathol 2007; 20(2):167A.
  • Osunkoya AO, Epstein JI. Primary Mucin-Producing Urothelial-Type Adenocarcinoma of Prostate: Report of 15 Cases. Modern Pathol 2007; 20(2):167A.
  • Osunkoya AO, Truong C.D., Laszik Z.G.: TM but not EPCR Expression is Reduced in The Tubulointerstitial Capillaries of Patients with Proliferative and Membranous Lupus Nephritis. Lab Invest. 2006 Jan; 86(1):264A-265A.
  • Thor AD, Osunkoya AO. Giant Juvenile Fibroadenoma (GJF). American Society for Breast Disease (ASBD) Expert Advisor commentaries. May 2005.
  • Osunkoya AO, Foster T. and Pitha J. Ectopic Meningothelial Hamartoma of the Scalp. J Cutan Pathol 2005: 32: 107A.
  • Osunkoya AO, Aronson W, Kern W, Vogel S, Dunn T: Cavernous transformation of the portal vein in a patient with 50% reduction in Protein C, probable polycythemia vera and MTHFR C677T point mutation. Modern Pathol 2003;16(1):6A.