Profile of a Pathology Faculty Member

Pathology Faculty Photo

Fred Sanfilippo, MD, PhD

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Professor, Health Policy and Management, Rollins School of Public Health

Professor of Business Administration, Goizueta Business School

Director, Emory Healthcare Innovation Program

Pathology Division(s):
Clinical Pathology
Experimental Pathology
Email Address:   fred.sanfilippo@emory.edu

Education:

BA   University of Pennsylvania, - 1970
MSc   University of Pennsylvania, - 1972
PhD   Duke University, - 1975
MD   Duke University, - 1976
Residency   Anatomic and Clinical Pathology, 1976 - 1979
Fellowship   Immunopathology, 1977 - 1979

Research Interests:

- Research Interests Dr. Sanfilippos research projects have included studies in solid state physics, molecular biology and immunogenetics, clinical trials, development of diagnostics and therapeutics, and mechanisms of allograft and xenograft rejection and acceptance. His major research interests in Pathology and Laboratory Medicine have been in immunopathology, transplantation biology, and renal pathology. His current major interests continue to focus on the application of informatics to enhance the quality of healthcare delivery at the level of individuals and populations, and enhancement of organizational performance and culture.

Honors / Awards:

  • Gold Humanism Honor Society, Arnold P. Gold Foundation, 2005
  • Norman Cohn Hope Award, National Multiple Sclerosis Society, 2005
  • John Minton Hero of Hope Research Champion Medal of Honor, American Cancer Society, 2005
  • American Association for the Advancement of Science, Fellow, 2004
  • Distinguished Alumnus Award, Duke University Medical Center, 2004
  • Business Leader of the Year, Columbus Business First, 2003
  • Senior Fellow, Association of Pathology Chairs, 2002
  • Lya and Harrison Latta Lecture, UCLA, 1998
  • MSTP Distinguished Scientist Lecture, University of Rochester, 1994
  • Baxley Professor and Chair, John Hopkins Department of Pathology, 1993-2000
  • Reach for Sight Physician Investigator Award, 1990
  • Alpha Omega Alpha, National Medical Honor Society, 1987
  • Wiley D. Forbus Award, North Carolina Society of Pathologists, 1979
  • Kermit G. Osserman Award, Myasthenia Gravis Foundation, 1976
  • Thomas Jefferson Award, Duke University School of Medicine, 1976
  • Duke Endowment Award, King's Fund College, London, England, 1973
  • NIH Predoctoral Fellowship: Medical Scientist Training Program, Duke University, 1970-76
  • DFG Award, Max Planck Institute for Experimental Medicine, Gottingen, Germany, 1966-68

Specialty Boards:

  •  Anatomic and Clinical Pathology
  •  Immunopathology

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Ota H, Fox-Talbot K, Hu W, Qian Z, Sanfilippo F, Hruban RH, Baldwin WM: Terminal complement components mediate release of von Willebrand factor and adhesion of platelets in arteries of allografts. Transplantation 2005; 79:276-281.
  • Wasowska BA, Qian Z, Cangello DL, Behrens E, Elshimi T, van Tran T, Hu W, Sanfilippo, F, Baldwin W: Passive transfer of alloantibodies restores acute allograft rejection in IgKO mice. Transplantation 2001; 71: 727-736.
  • Qian Z, Wasowska B, Sanfilippo F, Baldwin WM: Hepatic source of C6 drives complement-mediated cardiac allograft injury. J Heart Lung Transplant. 2001; 20:227.
  • Baldwin, WM, Qian Z, Ota H, Hu W, Samaniego M, Wasowska B, Sanfilippo F, Hruban RH: Complement as a mediator of vascular inflammation and activation in allografts. J Heart Lung Transplant. 2000;19:723-730.
  • Baldwin WM, Samaniego-Picota M, Kasper EK, Clark A, Czader M, Rohde C, Zachary AA, Sanfilippo F, Hruban H: Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes. Transplantation 1999; 68:894-900.
  • Qian Z, Wasowska B, Behrens E, Brody J, Kadkol S, Horwitz L, Liu J, Lowenstein C, Hess A, Sanfilippo F, Baldwin WM: C6 produced by macrophages contributes to cardiac allograft rejection. A J Pathol 1999; 155:1293-1302.
  • Moldovan NI, Qian Z, Chen Y, Dong C, Ying A, Hruban R, Flavahan NA, Baldwin WM, Sanfilippo F, Goldschmidt-Clermont PJ: Fas-mediated apoptosis in accelerated graft arteriosclerosis. Angiogenesis 1998; 2:245-254.
  • Jakobs FM, Davis, EA, Qian Z, Liu DY, Baldwin WM, Sanfilippo F: The role of CD11b/CD18 mediated neutrophil adhesion in complement deficient xenograft recipients. Clin. Transplant 1997; 11:516.
  • Davis EA, Pruitt SK, Greene PS, Ibrahim S, Lam TT, Levin JL, Baldwin WM, Sanfilippo F: Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts. Transplantation 1996; 62:1018-1023.
  • Epstein JI, Walsh PC, Sanfilippo F: Clinical and cost impact of second-opinion pathology. Review of prostate biopsies prior to radical prostatectomy. Amer. J. Surg. Path. 1996; 20:851-857.
  • Ibrahim S, Jacobs F, Kittur D, Lindsley P, Hess A, Sanfilippo F, Baldwin WM: CTLA4Ig inhibition of alloantibody responses to repeated blood transfusions. Blood 1996; 88: 4594-4600.
  • Hahn AB, Foulks GN, Enger C, Fink N, Stark WJ, Hopkins KA, Sanfilippo F: The association of lymphocytotoxic antibodies with corneal allograft rejection in high-risk patients. Transplantation 1995; 59: 21-27.
  • Ibrahim S, Dawson DV, Sanfilippo F: Predominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO. Transplantation 1995; 59:724-728.
  • Brauer RB, Baldwin, WM, Wang D, Horwitz LR, Hess AD, Klein AS, Sanfilippo F: Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. J. Immunol. 1994; 153: 3168-76.
  • Howell DN, Ross JR, Miller SE, Sanfilippo F: Characterization of a novel family of ciliary body glycoproteins. Invest. Ophthal. Vis. Sci. 1994; 35:3308-3318.

Book Chapters -

  • Borowitz M and Sanfilippo F: The Role of Pathology and Laboratory Medicine in the Diagnosis of Cancer. In: Clinical Oncology 3rd Edition (M Abeloff et al, eds) Elsevier, NY; 2004:299-339.
  • Baldwin WM and Sanfilippo F: Xenograft Transplantation. In: Heart and Lung Transplantation, 2nd Ed. (WA Baumgartner, BA Reitz, E Kasper, J Theodore, eds.). WB Saunders, Orlando; 2001:521-530.
  • Baldwin WM and Sanfilippo F: Xenograft Transplantation. In: Heart and Lung Transplantation, 2nd Ed. (WA Baumgartner, BA Reitz, E Kasper, J Theodore, eds.). WB Saunders, Orlando; 2001:521-530.
  • Foulks GN, Sanfilippo F: The Role of Corneal Antigens in Graft Success or Failure. In: Corneal Surgery 3rd Edition (FS Brightbill, ed.). C. V. Mosby, St. Louis; 1999:906-913.
  • Epstein J, Sanfilippo F, eds: The Johns Hopkins Atlas of Surgical Pathology. Elsevier, NY; 1999.
  • Hruban RH, Baldwin WM, Sanfilippo F: Immunopathology of Rejection. In: Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (K Solez, L Racusen, ME Billingham, eds.). Marcel Dekker, N.Y.; 1996: 59-75.
  • Hruban RH, Baldwin WM, Sanfilippo F: Immunopathology of Rejection. In: Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (K Solez, L Racusen, ME Billingham, eds.). Marcel Dekker, N.Y.; 1996: 59-75.
  • Sanfilippo F: The Role and Methods of Histocompatibility Testing in Transplantation. In: Transplant Pathology (PC Kolbeck, RS Markin, BM McManus, eds.). ASCP Press, Chicago; 1994:19-44.
  • Sanfilippo F, Balber A, Granger D, McKinney R: Immune Response to Infection. In: Zinsser Microbiology, 20th Edition (WK Joklik, HP Willett, DB Amos, K Wilfert, eds.). Appleton and Lange, NY; 1992:345-368.
  • Sanfilippo F, Baldwin WM, Snyderman R: Immunopathology. In: Zinsser Microbiology, 20th Edition (WK Joklik, HP Willett, DB Amos, K Wilfert, eds.). Appleton and Lange, NY; 1992:311-326.
  • Amos DB and Sanfilippo F: The Immunology of Transplantation Antigens. In: Textbook of Surgery, 14th Edition (DC Sabiston, ed.). Saunders, NY; 1991:345-356.
  • Sanfilippo F and Amos DB: Mechanisms and Characteristics of Allograft Rejection. In: Textbook of Surgery, 14th Edition (DC Sabiston, ed.). Saunders, NY; 1991:357-373.
  • Sanfilippo F: Renal Transplantation. In: The Pathology of Organ Transplantation (GE Sale, ed.). Butterworths, London; 1990:51-101.
  • Sanfilippo F: The Use of Non-human Primates in Xenotransplantation. In: Xenograft-25 (M Hardy, ed.). Elsevier, NY; 1989:171-178.

Other Publications -

  • Sanfilippo F: Academic Health Centers. In: Engineering the Health System. (WB Rouse, D Cortese, eds). IOS Press; 2010: 383-414.
  • Sanfilippo F, Bendapudi N, Rucci A, Schlesinger L: Strong Leadership and Teamwork Drive Culture and Performance Change: Ohio State University Medical Center 2000-2006. Academic Medicine 2008; 83:845-854.
  • Bissell M and Sanfilippo F: Empowering patients with point-of-care testing. Trends in Biotechnol 2002; 20(6):269-270.
  • Sanfilippo F: Transplantation tolerance - the search continues. (Invited Editorial) N Engl J Med 1998; 339: 1700-1702.
  • Sanfilippo F: HLA matching in renal transplantation (Invited Editorial). N. Engl. J. Med. 1994; 331:803-805.