Profile of a Pathology Faculty Member

Pathology Faculty Photo

Karen P Mann, MD, PhD

Hematopathology

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Medical Director, Clinical Laboratories, Grady Health System
  • Chief Clinical Pathology, Grady Health System

Pathology Division(s):
Clinical Pathology

Email Address:   kmann@emory.edu

Education:

  University of Massachusetts, Amherst, MA, 1976 - 1978
A.B., magna cum laude   Harvard University, Boston, MA, 1978 - 1980
MD, PhD   Tufts University School of Medicine, Sackler School of Graduate Studies, Boston, MA, 1981 - 1988

Research Interests:

- Overview - My research interests focus on the development of new molecular diagnostic tests and flow cytometric targets which can aid in the diagnosis, subclassification, determination of prognosis, and treatment monitoring in patients with hematopoietic neoplasms. In addition, I am interested in evaluation of the usefulness of newly identified mutations both as diagnostic targets as well as possible targets of directed therapies. I am also interested in the monitoring and significance of minimal residual disease in different hematopoietic disorders.

Clinical Focus:

My clinical focus is in the area of neoplastic and non-neoplastic hematopathology of adults and children with an emphasis on a multifaceted approach including morphology, immunohistochemistry, flow cytometric immunophenotyping, fluorescence in situ hybridization, cytogenetics, and molecular testing. This approach is used to diagnosis the full range of hematopoietic malignancies and to evaluate for residual or recurrent disease following treatment. As Director of Molecular Hematopathology, I additionally have a leading role in supervising the development and evaluation of new molecular hematopathology tests in order to maintain a state-of-the-art diagnostic hematopathology laboratory.

Honors / Awards:

  • National Research Service Postdoctoral Fellowship Award, NIH, 1990
  • National Science Foundation Undergraduate Research Fellowship

    , 1979

Specialty Boards:

  • Certificate Anatomic Pathology; American Board of Pathology
  • Certificate Special Qualification in Hematopathology; American Board of Pathology
  • Certificate Molecular Genetic Pathology; American Board of Pathology

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms. Li S, Jaye DL, Bradley KT, Zhang L, Saxe D, Deeb G, Hill CE, Mann KP. Arch Pathol Lab Med. 2017 Mar;141(3):341-354. doi: 10.5858/arpa.2016-0260-SA. Epub 2017 Jan 5. Review. PMID: 28055240
  • Bernal-Mizrachi L, Guo X, Koff J, Moffitt A, Cinar M, Ramachandiran S, Chen Z, Switchenko J, Mosunjac M, Neill S, Mann KP et al. 2017. Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype. Oncogene.
  • Li S, Jaye DL, Bradley KT, Zhang L, Saxe D, Deeb G, Hill CE, Mann KP. 2017. Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms. Arch Pathol Lab Med. doi: 10.5858/arpa.2016-0260- SA. Early online release.
  • Fisher KE, Zhang L, Wang J, Smith GH, Newman S, Schneider TM, Pillai RN, Kudchadkar RR, Owonikoko TK, Ramalingam SS, Lawson, DH, Delman KA, El-Rayes BF Wilson MM, Sullivan HC, Morrison, AS, Balci S, Adsay NV, Gal AA, Sica GL, Saxe DF, Mann KP, Hill CE, Khuri FR, Rossi MR. 2016. Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies, Journal of Molecular Diagnostics: 18 (2) Pages: 299-315
  • Zhang L, Ramjit RT, Hill CE, Arellano M, Khoury HJ Rosado J, Mann KP. 2015. Clinical significance of quantitative monitoring and mutational analysis of BCR-ABL transcript in Philadelphia chromosome positive B lymphoblastic leukemia, Leukemia and Lymphoma. doi:10.3109/10428194.2014.1003059. [Epub ahead of print]
  • Maier CL, Fisher KE, Jones,HH, Hill CE, Mann KP, Zhang L. 2015. Development and Validation of CALR Mutation Testing for Clinical Diagnosis. AJCP. http://dx.doi.org/10.1309/AJCPXPA83MVCTSOQ 738-745 First published online: 1 November 2015
  • Tong AKT, Schuster DM, Mann KP, Yan X. 2014. A Rare Presentation of Myocardial Plasmacytoma Assessed by FDG PET/CT. Clin Nucl Med 39(7): 643-645, Jul.
  • Ramachandiran S1, Adon A, Guo X, Wang Y, Wang H, Chen Z, Kowalski J, Sunay UR, Young AN, Brown T, Mar JC, Du Y, Fu H, Mann KP, Natkunam Y, Boise LH, Saavedra HI, Lossos IS, Bernal-Mizrachi L. 2014. Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-¿B pathway. Int J Cancer. doi: 10.1002/ijc.29301. [Epub ahead of print]
  • Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G, Lugar P, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann, KP et al. 2013. Genetic Heterogeneity of Diffuse Large B Cell Lymphoma. Proc Natl Acad Sci USA. 110(4): 1398-1403, Jan.
  • Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G, Lugar P, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann, KP et al. 2013. Genetic Heterogeneity of Diffuse Large B Cell Lymphoma. Proc Natl Acad Sci USA. 110(4): 1398-1403, Jan.
  • Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WW, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann Karen P. Mann, MD, PhD 11/1/2016 Page 20 KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. 2012. The Genetic Landscape of Mutations in Burkitt Lymphoma. Nat Genet 44:1321-1325, Dec.
  • Lima L, Bernal-Mizrachi L, Saxe D, Mann KP, Tighiouart M, Arellano M, Heffner L, McLemore M, Langston A, Winton E, Khoury HJ. 2010. Peripheral blood monitoring of chronic myeloid leukemia during treatment with Imatinib, second-line agents and beyond. Cancer 117:1245-1252, Mar.
  • Mann KP. 2010. Gene patents: perspectives from the clinical laboratory. Mol Diagn Ther 14:137-140.
  • Mann KP. 2010. Gene patents: a view from the clinical laboratory. Expert Rev Mol Diagn 10:123-125, Mar.
  • Jima DJ, Zhang J, Jacobs C, Richards KL, Dunphy C, Choi WL, Au WY, Srivastava G, Czader, MB, Rizzieri D, Lagoo AS, Mann KP, Flowers CR, Khoury HJ, Sunay D, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson M, Gill JI, Kahl BS, Gao Y, Xie B, Patel A, Wu H, ZHU J, Lugar PL, Lipsky PE, Dressman H, Chadburn A, Dave SS. 2010. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood 116: 118-127.

Book Chapters -

  • Mann KP. Molecular Hematopathology. In: Hunt J, Ed: Molecular Oncology, Surgical Pathology Clinics, 2012, Vol 5(4): Elsevier, Inc
  • Mann KP, Saxe, DF. 2010. Molecular Pathology of Acute Myeloid Leukemias. In: Crisan, D, Ed: Hematopathology: Genomic Mechanisms of Neoplastic Diseases: Springer/ Humana Press.
  • Mann KP, McLendon RE, Provenzale J. 1999. Malignant lymphomas and hematopoietic neoplasms of the central nervous system. In McLendon, RE, Bigner, DD, Bigner, SH and Provenzale, J, Eds: Pathology of Tumors of the Central Nervous System: A Guide to Histologic Diagnosis, London: Edward Arnold.
  • Patel DD, Fong AM, Mann KP, Sundy JS, Whichard LP. 1997. CD166 Workshop: Tissue distribution and functional analysis of antibodies reactive with CD166, a ligand for CD6. In: Leucocyte Typing VI, T. Kishimoto, et al., eds. 461-464.

Other Publications -

  • Jacobs CL, Patel A, Jima D, Liu Q, Greenough A, Zhang J, Dunphy C, Richards K, Choi W, Srivsatava G, Au W, Evens AM, Gordon LI, Czader M, Rizzieri DA, Lagoo AS, Mann KP, et al. 2010. Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma. ASH Annual Meeting Abstracts. 116(21):803, Nov.
  • Ramji1 RT, Hill CE, Khoury HJ, Lima L, Mann K. 2010. B-Lymphoblastic Leukemia/ Lymphoma with t(9;22)(q34;q11.2): Monitoring of BCR-ABL1 transcript level by Q-RT-PCR, correlation with treatment and other methods of MRD monitoring. J Molecular Diagnostics 12:869.
  • Khoury HJ, Lima L, Saxe D, Mann KP, Arellano M, Heffner L, Bernal-Mizrachi L, McLemore M, Langston A, Winton E. 2009. Monitoring chronic myeloid leukemia (CML) response to tyrosine kinase inhibitors (TKI) and homoharringtonine (HHT) using peripheral blood (PB) fluorescence in situ hybridization (FISH) and quantitative RT-PCR (Q-PCR): Are bone marrow biopsies still needed? J Clin Oncol 27:15s, (suppl; abstr 7064).
  • Carter AB, Schniederjan S, Mann, K. 2009. Software for the Laboratory: The Blood and Bone Marrow Counter. (Abstract) Arch Pathol Lab Med 133:1150, July.
  • Lima L, Assouline SE, Saxe D, Mann K, McLemore M, Souza L, Arellano M, Winton EF, Bernal-Mizrachi L, Khoury HJ. 2009. Does pre-imatinib (IM) fluorescence in situ hybridization (FISH) predict myelosuppression and outcomes in chronic myeloid leukemia (CML)? J Clin Oncol 27:15s, (suppl; abstr 7071).
  • Jacobs CL, Lagoo AS, Dash RC, Raji A, Evens AM, Winter JN, Gordon LI, Kahl BS, Czader M, Srivastava G, Mann KP, Gill J, Rizzieri D, Dave S. 2008. MicroRNAs Distinguish Burkitt Lymphoma from the Molecular Subsets of Diffuse Large B Cell Lymphoma. ASH Abstracts. Blood 112:1151, Nov. (www.bloodjournal.org)
  • Cole JM, Sinha R, Flowers C, Mann K. 2008. Clinical Laboratory Validation of InVivoScribe LymphotrakTM IgH TrackTwoTM Assays for the Detection of Minimal Residual Disease in CLL/SLL. AMP Abstracts. J Molecular Diagnostics 10:584, Nov. (http://jmd.amipathol.org)
  • Bradley KT, Rosado J, Mann KP. 2008. Evaluation of Signature¿ Primers and Signature¿ Probes (ASR) for Detection of Leukemia-Associated Translocations. AMP Abstracts. J Molecular Diagnostics 10:583, Nov. (http://jmd.amipathol.org)
  • Kost CB, Holden JT, Mann KP. 2005. Marginal Zone Lymphoma: A Retrospective Immunophenotypic Analysis Modern Path 18:238a.
  • Djalilvand A, Hill CE, Mann KP. 2005. Comparison of Analysis Methods for Identification of T Cell Clonality Using PCR with Capillary Electrophoresis. Modern Path 18:227a
  • Park SI, Bell J, Mann KP, Holden JT. CD13 Expression by IGM-Producing Low Grade B-Cell Lymphomas. Modern Path 18:245a.
  • Halkos ME, Miller JI, Mann KP, Miller DL, Gal AA. 2003. Thoracic presentations of post-transplant lymphoproliferative disorders. Chest (Submitted).
  • Wadleigh M, Niedzwiecki D, Davis P, Payne N, Sen F, Mann KP, Proia A, Hollis D, Rizzieri DA. 2001. Increased microvessel density in non-Hodgkin's lymphoma (NHL) is localized to the site of disease changes in accordance with disease response. Blood 98:4669.
  • Rizzieri DA, Wikstrand CJ, Mann KP, Sen F, Proia AD, Niedzwiecki D, Bigner DD, Vredenburgh J. 1999. Markers of angiogenesis, factor VIII and tenascin, correlate with disease activity in patients with non-Hodgkin's lymphoma. Blood 94:4339.
  • Smith C, Lilly S, Mann KP, Livingston E, Myers S, Lyerly HK, Miralles GD. 1998. AIDS-related malignancies [Review]. Annals of Medicine 30:323-344.
  • Liu K, Liu J, Mann KP, McLendon R, Traweek ST. 1997. B-cell clonality in Castleman's disease, plasma cell type. Lab Invest 76:752.
  • Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and its ligand, ALCAM, on hematopoietic malignancies of the myeloid and B-cell lineages. Tissue Antigens 48:AS403.
  • Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and CD6L(ALCAM) in hematopoietic neoplasms. Cytometry 26:343.
  • Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and CD6L(ALCAM) in hematopoietic neoplasms. Cytometry 26:343.
  • McLendon RE, Friedman AH, Provenzale JM, Brown MT, Mann KP. 1996. Castleman's disease (plasma cell variant) confined to the leptomeninges. J Neuropathol Exp Neurol 55: 76.
  • Mann KP, Liu J, DeCastro CM, Moore JO, Bigner S, Traweek ST. 1995. CD56 (N-CAM) expression in acute non-lymphoid leukemia (ANLL) and Myelodysplastic syndrome (MDS). Mod Pathol 9:116a.
  • Rizzieri DA, DeCastro CM, Mann KP, Moore JO. 1995. T cell lymphoblastic leukemia with mediastinal mass and c-kit expression. Blood 86(suppl 1):777a.
  • DeCastro CM, Moore JO, Traweek T, Mann KP. 1995. Bone marrow necrosis secondary to hydroxyurea treatment for the retinoic acid syndrome. Blood 86(suppl 1): 755a.
  • Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H. 1994. Neutrophil rich Ki-1positive anaplastic large cell malignant lymphoma. Mod Pathol 7:114a.
  • Mann KP, Weiss EA, Nevins JR. 1991. Role of polyadenylation factors, particularly the downstream specific factor, in selective poly(A) site utilization. Presented at Cold Spring Harbor Laboratories meeting on RNA Processing.
  • Mann KP. 1986. The identification and characterization of an Epstein-Barr virus protein found in the plasma membrane of latently infected cells. Ph.D. Dissertation. Sackler School of Graduate Biomedical Sciences, Tufts University.