Profile of a Pathology Faculty Member

Pathology Faculty Photo

Shiyong Li, MD, PhD

Hematopathology

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Member, Winship Cancer Institute
  • Attending Hematopathologist, Emory University Hospital
  • Attending Molecular Genetic Pathologist, Emory University Hospital
  • Medical Director, Flow Cytometry Laboratory, Emory University Hospital
  • Director, Hematopathology, Emory University Hospital

Pathology Division(s):
Clinical Pathology

Email Address:   sli2@emory.edu

Education:

MD   AnHui Medical University, China, 1979 - 1984
PhD   University of Iowa, 1989 - 1995
Residency   University of Pennsylvania Hospital, 1995 - 1999
Fellowship   Johns Hopkins Hospital, 1999 - 2000

Research Interests:

- Hematolymphoid malignancies Using modern technology such as flow cytometry, fluorescent in situ hybridization, laser-captured microdissection and cDNA microarray, I am especially interested in (1) investigation of the underlying molecular mechanisms of leukemo/lymphomagenesis; (2) identification of new marker(s) to aid in diagnosis and in predicting the clinical outcome of malignant hematopoietic disorders; (3) development of new diagnostic tests in the field of hematopathology.

Clinical Focus:

Hematopathology - morphology, flow cytometry and molecular diagnostics Fluorescence in situ hybridization for hematolymphoid and solid organ tissue malignancies

Honors / Awards:

  • The Emory Golden Apple Teaching Award

    , 2010-2011

  • The Emory Golden Apple Teaching Award, 2003-2004
  • CUSBEA Scholar, 1989-1995

Specialty Boards:

  •  Diplomate, Anatomic and Clinical Pathology, American Board of Pathology
  •  Diplomate, Hematology, American Board of Pathology
  •  Diplomate, Molecular Genetic Pathology, American Board of Pathology

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Wang HY, Huang L, Garcia R, Li S and Galliani CA (2011) Erythroblastic Sarcoma Presenting as Bilateral Ovarian Masses in an Infant with Pure Erythroid Leukemia. Human Pathology 42:749-58.
  • Ahsanuddin A, Brynes RK and Li S (2011) Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: Report of 3 cases and review of the literature. Int J Clin Exp Pathol 4; 416-20.
  • Cotta CV, Coleman JF, Li S and His ED (2011). Progression of nodular lymphocyte predominant Hodgkin lymphoma to diffuse large B-cell lymphoma: a study of 6 cases concurrently involving the same site. Histopathology (in press)
  • Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP (2010) A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. Am J Clin Pathol 133:718-26.
  • Li S and Lee AK (2010) Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction? Int J Clin Exp Pathol 3:117-127.
  • Zapata M, Budnick SD, Bordoni R and Li S (2010). An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma. Int J Clin Exp Pathol 3:430-6.
  • Kraus TS, Sillings CN, Saxe DF, Li S and Jaye DL (2010). The role of CD11c expression in the diagnosis of mantle cell lymphoma. Am J Clin Pathol 134:271-7.
  • Wang HY*, Li S*, Woodford RL, Cousar JB and Mills SE (2010) BCL2 chromosomal translocation is not a general feature of the interdigitating dendritic cell sarcoma. Diag Mol Pathol 19:169-71 (*co-first author)
  • Li S (2009). Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a distinct clinicopathological entity Int J Clin Exp Pathol 2: 508-518
  • Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR and Li J-J (2009) NF-kappB-mediated HER-2 overexpression in radiation-induced adaptive tumor resistance. Radiation Res 171, 9-21.
  • Zeng W, Styblo TM, Li S, Sepulveda JN and Schuster D (2009) Breast angiosarcoma: PDG PET findings. Clin Nucl Med 34: 443-445.
  • Salisbury CL, Budnick SD and Li S (2009) T-cell receptor gene rearrangement and CD30 immunoreactivity in traumatic ulcerative granuloma with stromal eosinophilia of the oral cavity. Am J Clin Pathol 132: 722-727.
  • Chan C-B, Hao C, Abe M, Hashimoto N, Nakao S, Liu X, Williams IR, Yepes M, Li S, Asano M, Hara-Nishimura I, Luo HR and Ye K (2009) Mice lacking asparagine endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome. Proc Natl Acad Sci USA 106, 468-473.
  • Webber BA, Cushing MM and Li S (2008) Prognostic significance of flow cytometric immunophenotyping in acute myeloid leukemia. Int J Clin Exp Pathol 1:124-133.
  • Li S, Mann KP and Holden JT (2008) Composite small lymphocytic lymphoma and extramedullary myeloid tumor: a potential diagnostic pitfall. Int J Clin Exp Pathol 1, 91-97.

Book Chapters -

  • Li, S. (1999). Complementary DNA microarray: the bridge between molecular biology and pathology. In: Advances in Medical Molecular Biology, Y.-F. Shen (ed.), pp137-143, Beijing and Springer-Verlag Heidelberg.

Other Publications -

  • Li S (2011) T cell prolymphocytic leukemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology
  • Li S (2011) Diffuse large B-cell lymphoma - monomorphic posttransplant lymphoproliferative disorder. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology
  • Li S (2010) Burkitt lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Woodford RL, Wang HY, Li S, Mills SE and Cousar JB. T(14;18)-negative interdigitating dendritic cell sarcomas: a morphologic and immunohistochemical review. USCAP meeting, 2010, Washington DC.
  • Li S (2010) Transformation of nodular lymphocyte-predominant Hodgkin lymphoma to diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Wertheim GBW, Roullet M, Jones D, Young KH, Li S, Wu H and Choi JK. Sensitive and specific detection of gamma T-cell receptor in paraffin-embedded T-cell lymphomas. USCAP meeting, 2010, Washington DC.
  • Li S (2009) Cutaneous mastocytoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Kossover C, Budnick S and Li S. Clonal T-cell receptor gene rearrangements in traumatic ulcerative granuloma with stromal eosinophilia. USCAP meeting, 2009, Boston.
  • Li S (2009) Peripheralization of malignant lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP. A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. USCAP meeting, 2009, Boston
  • Roullet M, Gheith S, Mauger J, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cells in panniculitis by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA
  • Li S (2008) Primary central nervous system diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology
  • Roullet M, Gheith S, Cornfield D, Mauger J, Wu H, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cell lymphoma by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA
  • Cao N, Li S, Wang Z, Degnan M, Fan M, Ahmed KM and Li J-J (2008) NF-kappB-mediated HER-2 overexpression in acquired tumor radioresistance. AACR meeting, Phoenix, Arizona
  • Kossover CL, Budnick SD and Li S (2008) Traumatic ulcerative granuloma with stromal eosinophilia: reactive ulcer or lymphoproliferative disorder? USCAP meeting, Denver, CO
  • Li S (2008) Systemic lupus lymphadenitis. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Zapata M, Choi W and Li S (2007) CD5-positive B cell lymphoma with coexpression of FMC7 and CD23: mantle cell lymphoma or small lymphocytic lymphoma? Clinical Cytometry Society meeting, Washington DC
  • Amanuel B, Deyrup AT, Hill CE, Foulks C, Blasingame A, Li S and Weiss SW (2007) Molecular testing of for synovial sarcoma. Australian Division of IAP meeting, Autralia
  • Li S (2007) Diamond-Blackfan anemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology
  • Li S (2007) Classical Hodgkin lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Li S (2006) Heinz body-induced hemolysis. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of acute myeloid leukemia (AML) at diagnosis and relapse. USCAP meeting, Vancouver, BC, Canada
  • Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of precursor B-cell acute lymphoblastic leukemia(B-ALL): Correlation with short-term treatment outcomes. USCAP meeting, Vancouver, BC, Canada
  • Zornosa X and Budnick S and Li S (2003) Lymphoma of the head and neck: a retrospective study. Am Acad Oral Maxillofacial Pathol Meeting, Banff, Canada
  • Li S, Chen X and Jensen PE (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. USCAP meeting, Washington DC
  • Li S (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.
  • Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L and Jensen PE (2001) Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. ASHI meeting, San Francisco, CA
  • Li S, Mann KP and Holden JT (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.
  • Li, S, Eshleman JR and Borowitz MJ (2001) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkin's lymphoma. USCAP meeting, Atlanta, GA
  • Li S, Ross DT, Kadin ME, Brown PO and Wasik MA (2000) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. USCAP meeting, New Orleans, LA
  • Li S, Baloch ZW, Tomaszewski JE and LiVolsi VA (1999) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. IAP meeting, France