Profile of a Pathology Faculty Member

Pathology Faculty Photo

Keqiang Ye, PhD

Cancer Biology

Pathology & Laboratory Medicine

Other Appointments/Positions

Professor, Pharmacology Graduate Program (MSP)

Professor, Biochemistry and Cell & Development Graduate Program

Pathology Division(s):
Experimental Pathology
Email Address:


BS   Chemistry, Jilin University, - 1990
MS   Chemistry, Beijing University, - 1993
PhD   Biochemistry, Emory University, - 1998
PostDoc   Neuroscience, Johns Hopkins University, - 2001

Research Interests:

- How NGF regulates neuronal cell survival in the nucleus To study neurotrophin signalings in neuronal cell survival and drug discovery in neuroprotection. To dissect the physiological roles of PIKE in tumorigenesis and anti-cancer drug development To determine the neuronal cell death molecular mechanisms of neuroexcitotoxicity and stroke in central nervous system and drug discovery

Honors / Awards:

  • The Sontag Foundation for Distinguished Scientist Award(2003) Nominee from Emory for the Keck Foundation (2004) American Cancer Society Scholar (2004), 2001-present

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Jee-Yin Ahn, Xia Liu, Pui-Kwang Chan, Dongmei Cheng, Junming Peng, Paul A. Wade and Keqiang Ye (2005). Nucleophosmin/B23, a Nuclear PI (3,4,5)P3 Receptor, Mediates the Anti-apoptotic Actions of NGF by Inhibiting CAD. Molecular Cell 18, 435-445.
  • Yuanxin Hu, Xia Liu, Haian Fu and Keqiang Ye (2005). Akt Phosphorylates Acinus and Inhibits its Proteolytic Cleavage, Preventing Chromatin Condensation. EMBO Journal 24: 3543-3554.
  • Yuanxin Hu, Zhixue Liu and Keqiang Ye (2005). Phosphoinositol Lipids Bind to PIKE GTPase and Mediate its Stimulatory Effect on PI 3-kinase and Akt Signalings. Proc. Natl. Acad. Sci. USA. 102: 16853-16858.
  • Jee-Yin Ahn and Keqiang Ye (2005). PIKE GTPase Signaling and Function. Inter. J. Biol. Sci. 1, 44-51.
  • Xia Liu and Keqiang Ye (2005). Src Homology Domains in Phospholipase C-1 Mediate its Anti-apoptotic Action Through Regulating the Enzymatic Activity. J. Neurochem. 93, 892-898.
  • Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Erwin G. van Meir and Keqiang Ye (2004) PIKE-A is amplified in human cancers and prevents apoptosis by upregulating Akt. Proc. Natl. Acad. Sci. USA.101 (18):6993-8.
  • Jee-Yin Ahn, Rong Rong, Xuesong Liu and Keqiang Ye (2004). PIKE/nuclear PI 3-Kinase Mediates the Anti-apoptotic Actions of NGF in the Nucleus. EMBO Journal 23(20):3995-4006.
  • Rong Rong, Ezequiel I. Surace, Carrie A. Haipek, David H. Gutmann and Keqiang Ye (2004). Serine 518 Phosphorylation Modulates Merlin Intramolecular Association and Binding to Critical Effectors Important for NF2 Growth Suppression. Oncogene 23, 8447-8454.
  • Rong Rong, Xiaoling Tang, David H. Gutmann and Keqiang Ye (2004). The neurofibromatosis 2 (NF2) tumor suppressor, merlin, inhibits PI 3-kinase through interaction with PIKE-L. Proc. Natl. Acad. Sci. USA. 101, 18200-18205.
  • Jee-Yin Ahn, Rong Rong, Todd G. Kroll, Erwin G. Van Meir, Solomon H. Snyder and Keqiang Ye (2004). PIKE-A, a Novel GTPase, is a Physiologic Regulator of Akt and Mediates Cellular Invasion. J. Biol.Chem. 279 (16):16441-51.
  • Keqiang Ye and Solomon H. Snyder (2004). PIKE GTPase: a novel mediator of phosphoinositide signaling. J. Cell Science, 117, 155-161.
  • Hongbo R. Luo, Yi Elaine Huang, Jianmeng C. Chen, Adolfo Saiardi, Miho Iijima, Keqiang Ye, Yunfei Huang, Eiichiro Nagata, Peter Devreotes and Solomon H. Snyder (2003). Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell, 114, 559-572.
  • Rong Rong, Jee-Yin Ahn, Peng Chen and Keqiang Ye (2003). The phospholipase activity of PLC-_1 is required for NGF to activate MAP kinase pathway in PC12 cells. J Biol Chem 278, 52497-52503.
  • Rong Rong, Honglian Huang, Eiichiro Nagata, Daniel Kalman, Judith A. Kapp, Jiancheng Tu, Paul F. Worley, Solomon H. Snyder and Keqiang Ye (2003). PIKE-L/Homer Complex Couples mGluR I to PI 3-kinase, Preventing Neuronal Apoptosis. Nature Neuroscience 6, 1153-1161.
  • Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell P, Govindarajan B, Der C, Battle T, Frank DA, Ye Keqiang, Murad E, Dubiel W, Soff G, Arbiser JL (2003). Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 278, 35501-7.

Books Edited and Written -

  • Keqiang Ye (2005). PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. J. Cell. Biochem. Review article, 96(3) 463-472.
  • Keqiang Ye (2005). PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. J. Cell. Biochem. Review article, 96(3) 463-472.